Search results for "Presentation"
showing 10 items of 2405 documents
Image of a Local Area: Measuring and Managing
2018
The image of a local area can be conceived as cumulative beliefs, ideas, opinions, and experiences people have about a place. Image embodies a large number of information, memories, and suggestions that pertain to a specific place, which are processed by human mind by selecting relevant evidence from a big amount of data about a local area. Image conceptualizes the value and/or a certain level of performance that a place expresses and it inspires human behaviors. The image of a local area is perceiveid by people, it is part of knowledge structures related to a place and it is long-lasting and difficult to change. Measuring and managing the image of a local area can support the socioeconomic…
The T-cell response in patients with cancer
2002
Publisher Summary The chapter examines several methods to measure human T-cell responses, including ELISPOT analysis, intracellular cytokine staining of immune cells after antigenic stimulation, limiting dilution analysis, conventional cloning, and molecular definition of the T-cell response either in the peripheral circulation or in situ in patients with cancer The chapter presents the cellular immune response in patients with cancer. The chapter explores the recent studies that suggest humoral immunity and T-cell-mediated immunity are closely linked. In addition, most of the data concerning antitumor immune responses have been generated using MHC class I tetramer reagents. The ultimate go…
Dendritic cells and the handling of antigen
2003
Dendritic cells (DC) are a sparsely distributed, migratory group of bone marrow-derived leucocytes that are specialized for the uptake, transport, processing and presentation of antigens to T cells [1,2]. At an immature stage of development DC are considered as the first-line sentinels in immune surveillance of peripheral tissues, including epithelia of the skin and mucosal surfaces, where they sample continuously the antigenic local microenvironment by uptake of self- and exogenous antigen via macropinocytosis/endocytosis [3,4]. The efficiency of DC to initiate an immune response against infectious disease is due to their constant trafficking between peripheral tissues and draining lymph n…
Costimulatory signalling potential of murine MHC class II‐positive T‐clone cells
1996
Activated human and rat T cells as well as mouse T-cell clones have been reported to synthesize and express major histocompatibility complex (MHC) class II molecules. However, the capacity of class II+ antigen (Ag) presenting T cells to induce proliferation of Ag-specific cloned T cells has been controversial. We analysed whether the failure of some T-cell clones to proliferate in response to Ag presented by class II+ T cells is because of a lack of costimulatory cytokine production by the antigen-presenting cells (APC). As a model system the mouse class II+ cloned BI/O4.1 T cells were used as APC in order to activate the T cell clone KIII5. This T-helper 1 (Th1) type, GAT (synthetic copoly…
Stalemating a clever opportunist: lessons from murine cytomegalovirus.
2003
Abstract Cytomegaloviruses and their specific hosts have come to an arrangement that avoids disease but allows the viruses to persist in the individual host and to spread in the host species. Recent work has uncovered some of the molecular details of this evolutionary “contract for mutual survival.” Cytomegaloviruses encode proteins, referred to as “immunoevasins,” which are specifically committed to subvert the immune defense of the host for evading virus elimination. In reply, the hosts have evolved countermeasures to overcome the viral immunoevasins and present antigenic peptides to an extent that is sufficient for confining virus replication to below a harmful level. Accordingly, cytome…
Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
2000
ABSTRACTThe mouse cytomegalovirus (MCMV)m152- andm06-encoded glycoproteins gp40 and gp48, respectively, independently downregulate major histocompatibility complex (MHC) class I surface expression during the course of productive MCMV infection in fibroblasts. As a result, presentation of an immediate-early protein pp89-derived nonapeptide toH-2Ld-restricted CD8+cytotoxic T cells is completely prevented in fibroblasts. Here we demonstrate that MCMV-infected primary bone marrow macrophages and the macrophage cell line J774 constitutively present pp89 peptides during permissive MCMV infection to cytotoxic T lymphocytes (CTL). In contrast to fibroblasts, expression of them152andm06genes in macr…
Toll-like receptors – sentries in the B-cell response
2009
Summary Toll-like receptors (TLR) play a central role in the initiation of the innate immune response to pathogens. Upon recognition of molecular motifs specific for microbial molecules TLR mediate pro-inflammatory cytokine secretion and enhance antigen presentation; in B cells they further promote expansion, class switch recombination and immunoglobulin secretion. As a result of their adjuvant properties, TLR ligands have become an integral component of antimicrobial vaccines. In spite of this, little is known of the direct effects of TLR engagement on B-lymphocyte function. The scope of this review is to outline the differences in TLR expression and reactivity in murine and human B-cell s…
Interaction affordances in traditional instruments and tablet computers: A study of children’s musical group creativity
2019
In order to promote children’s collaborative musical creativity in new digital environments, we need a better understanding not only of the sound production capabilities provided by the new digital tools, but also of the interaction affordances involved. This study focuses on the interactional patterns emerging in children’s musical creativity, comparing creative group processes on iPad tablet computers (with GarageBand software) to processes on traditional musical instruments. Both instrumentations were assigned to five groups of four 10–12-year-olds for creating sound landscapes for a “space” movie. The traditional instrument groups’ processes were characterized by peer teaching as well …
La dimensione tecnologica del museo: forme, tecniche, "identità mutanti" tra storia e contemporaneità
2005
Nella cultura contemporanea il tema della conservazione dell’eredità storica, della rappresentazione e della trasmissibilità dell’arte è argomento ampiamente dibattuto. La forza culturale del museo, detentore dell’eredità, può essere interpretata secondo diverse traiettorie di forme. La memoria intende esprimersi sulle origini e sul significato della "macchina museale" attraverso l’analisi critica dell’oggetto, sia esso contenitore, palco di rappresentazione o scena interattiva. Sonda i processi di comunicazione relativamente alla forma architettonica, alla funzione ed alla fruizione del prodotto espositivo. Tenendo conto delle diverse scuole di pensiero sulla spettacolarizzazione dell’arte…
"Figure 8b" of "Production of (anti-)$^3$He and (anti-)$^3$H in p-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 5.02 TeV"
2020
Coalescence parameter $B_3$ calculated using the average of $\mathrm{INEL}>0$ $^3\mathrm{H}$ and $^3\overline{\mathrm{H}}$ yields