Search results for "Prevention"
showing 10 items of 1662 documents
Protocol for the EARCO Registry
2020
Rationale and objectives Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that leads to an increased risk of emphysema and liver disease. Despite extensive investigation, there remain unanswered questions concerning the natural history, pathophysiology, genetics and the prognosis of the lung disease in association with AATD. The European Alpha-1 Clinical Research Collaboration (EARCO) is designed to bring together researchers from European countries and to create a standardised database for the follow-up of patients with AATD. Study design and population The EARCO Registry is a non-interventional, multicentre, pan-European, longitudinal observational cohort study enrolling patie…
Escala de desarrollo armónico (EDA): Una propuesta para la evaluación clínica del desarrollo infantil desde la Teoría de Sistemas
2020
Los profesionales de las ciencias de la salud y de la educación necesitan herramientas adecuadas para llevar a cabo la prevención de los trastornos del desarrollo infantil. La Escala de Desarrollo Armónico –EDA–, se presenta como una propuesta que permite la coordinación interdisciplinaria y la colaboración de los educadores. La escala se ha construido para observar el ascenso del paisaje epigenético individual desde el paradigma de los sistemas dinámicos. Para lograrlo, se han estudiado parámetros que pueden explicar la evolución del sistema –índice de armonía y cociente de desarrollo estable–, un mecanismo del cambio –tirón cognitivo– y fuerzas moldeadoras –velocidad y cristalización–, si…
Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme E…
2015
<b><i>Background:</i></b> Recently, we have shown anti-proliferative and pro-apoptotic effects of indicaxanthin associated with epigenetic modulation of the onco-suppressor <i>p16</i><sup><i>INK4a</i></sup> in the human colon cancer cell line CACO2. In the present study, the epigenetic activity of indicaxanthin and the mechanisms involved were further investigated in other colorectal cancer cell lines. <b><i>Methods:</i></b> LOVO1, CACO2, HT29, HCT116, and DLD1 cells were used to evaluate the potential influence of consistent dietary concentrations of indicaxanthin on DNA methylation, and the epigenetic mech…
Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study
2016
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion); Ministerio de Sanidad y Consumo; Spanish Diabetes Society (SED)
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study…
2020
BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population.METHODS: In the double-blind, randomised CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [&l…
Global (pharmacological and non pharmacological) prevention of RSV infection
2012
Second-Generation Muslim Youth Between Perception and Change: A Case Study on the Prevention of Radicalization
2020
The following article presents the results of a research-action and an online communication campaign on the prevention of radicalization of second-generation young Italian Muslims as a part of a project called “Oltre” (the Italian acronym means “Beyond”) financed by European Union. After a short presentation of the four steps of the prevention communication model PKIC, a deepening on the radicalization factors, and a focus on the research-action methodology, the results of the research on some fundamental issues like the relationship with family and the relation with media and social media of the young interviewees, are shown. Finally, in the last part of the article, the interventions carr…
Estrategias de búsqueda de artículos de revistas españolas. Estudio de un caso: evaluación de la calidad de los sistemas de información
1995
ResumenObjetivosDescribir un procedimiento sistemático para la recuperación exhaustiva de trabajos publicados en revistas españolas sobre evaluación de los sistemas de información clínicos y sanitarios (1983–1992) y analizar los términos útiles, el aporte y los fallos de las fuentes.MétodosComo fuentes para la identificación de trabajos se ha utilizado la base de datos Índice Médico Español (IME), los sumarios de revistas y la bibliografía de los trabajos recuperados. Como variables de análisis se han utilizado los términos coincidentes entre perfil de búsqueda, títulos y palabras clave; Índices de aporte, aporte específico y solapamiento; y fallos del usuario, actualización y cobertura.Res…
Cancer incidence and mortality trends from 2003 to 2014 in Italy.
2019
Objective: To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy. Methods: Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates, overall and stratified by geographic area, region, sex, cancer site, and major age group, were computed. Time trends were expressed as annual percent change of rates. Results: In Italy, among males, incidence rates for all cancers showed during 2003–2014, a significant decrease (−0.9%/year), with stronger reductions in the northwest (−1.3%/year) …
Years of life that could be saved from prevention of hepatocellular carcinoma
2016
Summary Background Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim To assess how many years of life are lost after HCC diagnosis. Methods Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18–61 y…