6533b85bfe1ef96bd12bb465
RESEARCH PRODUCT
Years of life that could be saved from prevention of hepatocellular carcinoma
Andrea CostantinoMarcello MaidaFabio FarinatiLaura SchiadàStefano TamberiAlessandro MoscatelliElena RastrelliMaria ChiaramontePaolo PoggioGianluca Svegliati BaroniMatteo RenzulliPiscaglia FabioFilomena MoriscoPaola RoselliRoberto VirdoneAnna Maria LalungoMatteo RavaioliE.g. GianniniAnna Chiara Dall’aglioAntonio Daniele PinnaElena VavassoriFabiana MarchettiEugenio CaturelliMarco DomenicaliCalogero CammàGiulia BoscoCarla SerraClaudia BalsamoDonatella MagalottiGian Ludovico RapacciniValeria MismasS. GeminiStefano OlmiAlberto MasottoV. FelettiFrancesca MurerGaia PellegattaMaria Rosa BarcellonaA. GazzolaAndrea MegaLuigi BolondiPaolo CaraceniLaura BucciRita GolfieriAnnagiulia GramenziFrancesca CiccareseRodolfo SaccoCristina MosconiFranco BorzioEmanuele RinninellaM. Di MarcoAlberta CappelliMarco ZoliV. VaninLuisa BenvegnùMauro BernardiEmanuela PorroMatteo ValerioA. PecorelliAntonino PicciottoFederica Mirici CappaMartina FelderElisabetta BiasiniAntonio GasbarriniMaurizio BiselliAlessandro CucchettiGabriele MissaleL. VenerandiSerena Dell'isolaFranco TrevisaniElga NeriVincenzo SavarinoMaria GuarinoC. PozzanGiuseppe CabibboF.g. FoschiGiuseppe Francesco StefaniniArianna LanziAndrea Affrontisubject
RegistrieMalePediatricsDatabases FactualHepatocellular carcinoma0302 clinical medicineprevention80 and overSecondary PreventionPharmacology (medical)Prospective StudiesRegistriesYoung adultProspective cohort studySecondary preventionAged 80 and overeducation.field_of_studyLiver NeoplasmsGastroenterologyDisease ManagementMiddle AgedPrimary PreventiondiagnosiItalyLiver Neoplasm030220 oncology & carcinogenesisHepatocellular carcinoma030211 gastroenterology & hepatologyFemaleHumanAdultmedicine.medical_specialtyCarcinoma HepatocellularAdolescentPopulationlife expentancyMilan criteria03 medical and health sciencesDatabasesYoung AdultLife ExpectancymedicineHumansAdolescent; Adult; Aged; Aged 80 and over; Carcinoma Hepatocellular; Databases Factual; Disease Management; Female; Humans; Italy; Life Expectancy; Liver Neoplasms; Male; Middle Aged; Primary Prevention; Prospective Studies; Registries; Secondary Prevention; Young Adult; Pharmacology (medical)educationFactualAgedHepatologybusiness.industryCarcinomaSettore MED/09 - MEDICINA INTERNAHepatocellularmedicine.diseaseSurgeryProspective StudieYears of potential life lostLife expectancybusinessdescription
Summary Background Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim To assess how many years of life are lost after HCC diagnosis. Methods Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18–61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986–1999, to 10.7 in 2000–2006 and 7.4 years in 2007–2014. Currently, an HCC diagnosis when a single tumour <2 cm results in 3.7 years-of-life lost while the diagnosis when a single tumour ≥2 cm or 2/3 nodules still within the Milan criteria, results in 5.0 years-of-life lost, representing the loss of only approximately 5.5% and 7.2%, respectively, of the entire lifespan from birth. Conclusions Hepatocellular carcinoma occurrence results in the loss of a considerable number of years-of-life, especially for younger patients. In recent years, the increased possibility of effectively treating this tumour has improved life expectancy, thus reducing years-of-life lost.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |