Search results for "Proa"
showing 10 items of 1834 documents
Revista electrónica de investigación y evaluación educativa
2014
Resumen tomado de la publicación Título, resumen y palabras clave en inglés y español Se muestra el proceso seguido para diseñar e identificar las propiedades psicométricas del instrumento de evaluación del constructo Atención a la Diversidad como variable de contexto. Para ello, se ha comenzado con una pequeña revisión de los instrumentos utilizados para recoger información sobre la diversidad tanto cultural como social, lingüística o en capacidades. A continuación y, partiendo de una clasificación de los distintos enfoques teóricos, se ha construido un primer instrumento, apostando por un enfoque inclusivo. Posteriormente se procede a una validación por expertos. Tras la validación se tom…
Proactive maintenance of offshore wind turbine blades using knowledge-based force analysis
2013
The operation and maintenance (O&M) costs of wind turbines constitute approximately 10-15% of the lifecycle cost in onshore installations and up to 30% in offshore installations. The O&M costs for offshore wind power plants are higher than the onshore ones due to greater logistical challenges of maintaining and servicing, and the less mature state of offshore wind energy technology. Wind turbine blades suffer from various faults, for example, blade angle asymmetry, icing, and bends. These faults may cause wind turbines to a standstill. Replacement of rotor blades will normally result in a long downtime since the replacement process involves heavy transportation (vessel, crane) and dependenc…
Protocol for rational design of covalently interacting inhibitors.
2014
The inhibition potencies of covalent inhibitors mainly result from the formation of a covalent bond to the enzyme during the inhibition mechanism. This class of inhibitors has essentially been ignored in previous target-directed drug discovery projects because of concerns about possible side effects. However, their advantages, such as higher binding energies and longer drug-target residence times moved them into the focus of recent investigations. While the rational design of non-covalent inhibitors became standard the corresponding design of covalent inhibitors is still in its early stages. Potent covalent inhibitors can be retrieved from large compound libraries by covalent docking approa…
An overview of statin-induced myopathy and perspectives for the future
2020
Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin toxicity, in relation to clinical markers of disease, is of high importance. Areas covered: We summarized currently available findings (on PubMed) related to SAMS and discussed the therapeutic approaches,…
Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach
2021
Pharmacogenetics analyzes the individual behavior of DNA genes after the administration of a drug. Pharmacogenetic research has been implemented in recent years thanks to the improvement in genome sequencing techniques and molecular genetics. In addition to medical purposes, pharmacogenetics can constitute an important tool for clarifying the interpretation of toxicological data in post-mortem examinations, sometimes crucial for determining the cause and modality of death. The purpose of this systematic literature review is not only to raise awareness among the forensic community concerning pharmacogenetics, but also to provide a workflow for forensic toxicologists to follow in cases of unk…
How to keep patient case sheet flows under control? A subset of ad hoc indicators and its statistical control in a healthcare organization.
2009
SCELTA E APPLICAZIONE DI NUOVI STANDARD DI MANOVRA NELLE FASI DI DECOLLO ED ATTERRAGGIO DELL’ELICOTTERO - MODELLO E SPERIMENTAZIONE -
Una zona o un ambiente ha tipicamente un livello sonoro che lo caratterizza e ci si aspetta che le variazioni di quell’ambiente in equilibrio dovute ad un evento acustico insolito alterino le sensazioni delle persone in quel contesto. Non ci si può riferire al buon senso per valutare se disturbiamo o danneggiamo il prossimo, è necessario individuare le fonti di rumore e valutare l’impatto ambientale tramite indagini di tipo qualitativo e fasi sperimentali di misura. Lo studio condotto ha correlato il dato qualitativo a quello quantitativo sia in ambito predittivo che tramite rilievi sul campo. Gli scopi e gli obiettivi sono incentrati a: ricercare una simulazione coerente di propagazione de…
EMISSION FACTORS, VEHICLE MODAL ACTIVITY AND ROAD OPERATIONS. A MESOSCOPIC APPROACH
2009
Current studies underline that vehicle emissions are highly linked to modal vehicle activity and a modal approach to traffic-related air quality modeling is suitable to estimate mobile source contribution to air quality. Pollutant emissions depend on characteristics of vehicles in traffic flow and on road operating conditions predictable after the implementation of the road project; then, the usual emission rate models do not predict properly the on-road vehicles emissions of modal traffic events, such as those ones occurring at intersections. Moreover modal activity analysis carried out at micro scale level, as required by modal emission models, will be still necessary to value reliable em…
Implementation of the Smart City Concept in Post-Socialist Cities : Rationales, Results, and Recommendations
2018
Unveiling the strong interaction among hadrons at the LHC
2020
One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each other. Such scattering experiments are difficult or impossible for unstable hadrons3–6 and so high-quality measurements exist only for hadrons containing up and down quarks7. Here we demonstrate that measuring correlations in the momentum space between hadron pairs8–12 produced in ultrarelativistic…