Search results for "Proa"
showing 10 items of 1834 documents
Minä sairaanhoitajana: tulevaisuuden minuudet motivaatiota muokkaamassa
2013
Ulkomaalaisen terveydenhoitoalan henkiloston ammatillinen kielitaito on herattanyt julkista keskustelua Suomessa, mutta alalle kouluttautuvat maahanmuuttajataustaiset opiskelijat kielitaitoineen ovat olleet vasta vain tieteellisen keskustelun kohteena. Tassa artikkelissa tarkastelen, mita odotuksia Suomessa englanninkielisessa koulutusohjelmassa sairaanhoitajiksi opiskelevilla maahanmuuttajilla on kielitaidostaan ja tulevaisuudestaan ja kuinka odotukset nakyvat motivoituneisuutena tyoharjoitteluissa. Motivaatiota lahestytaan kompleksisena, identiteettiin nivoutuvana ilmiona, jonka ytimessa on toimijuus. Tutkimus sijoittuu sosiokognitiiviseen viitekehykseen, jossa kieli ja motivaatio nahdaan…
Polymeric proanthocyanidins from Sicilian pistachio (Pistacia vera L.) nut extract inhibit lipopolysaccharide-induced inflammatory response in RAW 26…
2011
Positive effects of pistachio nut consumption on plasma inflammatory biomarkers have been described; however, little is known about molecular events associated with these effects. We studied the anti-inflammatory activity of a hydrophilic extract from Sicilian Pistacia L. (HPE) in a macrophage model and investigated bioactive components relevant to the observed effects. HPE oligomer/polymer proanthocyanidin fractions were isolated by adsorbance chromatography, and components quantified as anthocyanidins after acidic hydrolysis. Isoflavones were measured by gradient elution HPLC analysis. RAW 264.7 murine macrophages were pre-incubated with either HPE (1- to 20-mg fresh nut equivalents) or i…
Chitosomes loaded with cranberry proanthocyanidins attenuate the bacterial lipopolysaccharide-induced expression of iNOS and COX-2 in raw 264.7 macro…
2009
Chitosan binds to negatively charged soy lecithin liposomes by an electrostatic interaction driven by its positively charged amino group. This interaction allows stable covered vesicles (chitosomes) to be developed as a suitable targeted carrier and controlled release system. This study investigated the effect of chitosomes on the activation of cranberry proanthocyanidins (PAC) in Raw 264.7 macrophages. Chitosomes were characterized according to size, zeta potential, PAC-loading, and release properties. Results showed an increase in the net positive charge and size of the liposomes as the concentration of chitosan was increased, suggesting an effective covering of the vesicles by means of e…
Sicily Network for Liver Cancer: A Multidisciplinary Network Model for the Management of Primary Liver Tumors
2020
Background: The management of primary liver tumors requires the involvement of multiple specialist skills and the best possible treatment in terms of cost, risk, and benefit that could be provided by hepatobiliary or transplant surgeon, interventional radiologist, hepatologist, radiotherapist, or oncologist is needed to be chosen for each patient. This is particularly relevant for hepatocellular carcinoma (HCC), that is the most common primary liver tumor, and it occurs in more than 90% of cases in the setting of cirrhosis. Methods: To address the increasing complexity of cancer care, multidisciplinary tumor boards (MDTBs) have evolved to offer patients appropriate and tailored cancer treat…
Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours
2019
Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the complexity of surgical options and the variety of medical treatments that require individual tailoring, mandate a multidisciplinary approach that can be optimally achieved through an organized network. The present study describes currents concepts in the management of these tumours as well as an insight into the challenges of delivering the pathway in and outside a Network.
The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation
2018
OBJECTIVE: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.BACKGROUND: The exponential growth of laparoscopic liver surgery in recent years mandates the development of clinical practice guidelines to direct the speciality's continued safe progression and dissemination.METHODS: A unique approach to the development of clinical guidelines was adopted. Three well-validated methods were integrated: the Scottish Intercollegiate Guidelines Network methodology for the assessment of evidence and development of guideline statements; th…
Sociodemographic and behavioural correlates of lifetime number of sexual partners: findings from the English Longitudinal Study of Ageing.
2018
BackgroundNo current data are available on correlates of lifetime sexual partners at older ages. This study aimed to explore correlates of the lifetime number of sexual partners in a sample of older adults.MethodData were from 3054 men and 3867 women aged ≥50 years participating in the English Longitudinal Study of Ageing. Participants reported their lifetime number of sexual partners and a range of sociodemographic characteristics and health behaviours. Multivariable multinomial logistic regression was used to examine correlates of lifetime number of sexual partners, with analyses performed separately for men and women and weighted for non-response.ResultsYounger age, being separated/divor…
Proactive and reactive aggression in early adolescence as precursors to anti- and prosocial behavior in young adults
1996
Three groups of adolescents who were 14 years old in 1974 were formed on the basis of peer nominations and teacher ratings in an ongoing longitudinal study: 1) reactively aggressive (REA) individuals who displayed reactive, that is, self-defensive aggression but not proactive aggression (43 boys, 35 girls); 2) proactively aggressive (PROA) individuals who attacked another person without a reason (56 boys, 35 girls); and 3) nonaggressive (NONA) individuals who were low in proactive and reactive aggression (48 boys, 45 girls). The groups were compared at ages 8, 14, and 27 in variables representing the constructs of a two-dimensional model of emotional and behavioral regulation. The REA Ss we…
Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19
2021
Abstract Objective The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19. Methods We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated. Results Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3–2.95 vs median, 0.82 nmol/L; interquartile range, 0.57–1.03; …
Reply to the letter to the editor ‘How much evidence isn't in evidence-based guidelines?’ by Johnson et al.
2015
ABSTRACT ESMO produces pan-European, multidisciplinary, peer-reviewed and updatable guidelines with global impact on current clinical practice, with the intention of providing the practising health professional in cancer care with an easy to use, evidence-based tool for optimal patient management. Levels of evidence and strength of recommendation metrics are provided. In the Dyspnoea ESMO CPG, we strove to fulfill these targets, though we accept any productive criticism that will contribute to the improvement of the product.