Search results for "Process"

2021

The hydrophobic tails of aliphatic primary alcohols do insert into the hydrophobic core of a lipid bilayer. Thereby, they disrupt hydrophobic interactions between the lipid molecules, resulting in a decreased lipid order, i.e., an increased membrane fluidity. While aromatic alcohols, such as 2-phenylethanol, also insert into lipid bilayers and disturb the membrane organization, the impact of aromatic alcohols on the structure of biological membranes, as well as the potential physiological implication of membrane incorporation has only been studied to a limited extent. Although diverse targets are discussed to be causing the bacteriostatic and bactericidal activity of 2-phenylethanol, it is …

A solution of the minimum-time velocity planning problem based on lattice theory

2018

For a vehicle on an assigned path, we find the minimum-time speed law that satisfies kinematic and dynamic constraints, related to maximum speed and maximum tangential and transversal acceleration. We present a necessary and sufficient condition for the feasibility of the problem and a simple operator, based on the solution of two ordinary differential equations, which computes the optimal solution. Theoretically, we show that the problem feasible set, if not empty, is a lattice, whose supremum element corresponds to the optimal solution.

GPU-Based Optimisation of 3D Sensor Placement Considering Redundancy, Range and Field of View

2020

This paper presents a novel and efficient solution for the 3D sensor placement problem based on GPU programming and massive parallelisation. Compared to prior art using gradient-search and mixed-integer based approaches, the method presented in this paper returns optimal or good results in a fraction of the time compared to previous approaches. The presented method allows for redundancy, i.e. requiring selected sub-volumes to be covered by at least n sensors. The presented results are for 3D sensors which have a visible volume represented by cones, but the method can easily be extended to work with sensors having other range and field of view shapes, such as 2D cameras and lidars.

Hybrid State Feedback Position-Force Control of Hydraulic Cylinder

2019

A hybrid position-force control is proposed using a unified state feedback controller in combination with feedforward dead-zone compensation. Dead-zone compensator was constructed as inverse of the identified static map while the state feedback gains were obtained using a numerical optimization routine. An accurate state-space model affine in states and control, derived in a previous work, was used for closed-loop simulations and control tuning. A trigger event for automatic switching between position and force control was defined and integrated into overall control architecture alongside with a feedforward low-pass filter reducing high frequency components in the control signal. Experiment…

Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology

2020

Safety evaluation of thousands of chemicals that are directly added to or come in contact with food is needed. Due to the central role of the liver in intermediary and energy metabolism and in the biotransformation of foreign compounds, the hepatotoxicity assessment is essential. New approach methodologies have been proposed for the safety evaluation of compounds with the idea of rapidly gaining insight into effects on biochemical mechanisms and cellular processes and screening large number of compounds. In this sense, high-content screening (HCS) is the application of automated microscopy and image analysis for better understanding of complex biological functions and mechanisms of toxicity…

NMR Exchange Format: a unified and open standard for representation of NMR restraint data

2015

SCOPUS: le.j

Towards identifying drug side effects from social media using active learning and crowd sourcing.

2019

Motivation Social media is a largely untapped source of information on side effects of drugs. Twitter in particular is widely used to report on everyday events and personal ailments. However, labeling this noisy data is a difficult problem because labeled training data is sparse and automatic labeling is error-prone. Crowd sourcing can help in such a scenario to obtain more reliable labels, but is expensive in comparison because workers have to be paid. To remedy this, semi-supervised active learning may reduce the number of labeled data needed and focus the manual labeling process on important information. Results We extracted data from Twitter using the public API. We subsequently use Ama…

Functional Foods: Product Development, Technological Trends, Efficacy Testing, and Safety

2020

Functional foods is a very popular term in the social and scientific media; consequently, food producers have invested resources in the development of processed foods that may provide added functional benefits to consumers’ well-being. Because of intrinsic regulation and end-of-use purposes in different countries, worldwide meanings and definitions of this term are still unclear. Hence, here we standardize this definition and propose a guideline to attest that some ingredients or foods truly deserve this special designation. Furthermore, focus is directed at the most recent studies and practical guidelines that can be used to develop and test the efficacy of potentially functional foods an…

Lysed Erythrocyte Membranes Promote Vascular Calcification

2019

Background: Intraplaque hemorrhage promotes atherosclerosis progression, and erythrocytes may contribute to this process. In this study we examined the effects of red blood cells on smooth muscle cell mineralization and vascular calcification and the possible mechanisms involved. Methods: Erythrocytes were isolated from human and murine whole blood. Intact and lysed erythrocytes and their membrane fraction or specific erythrocyte components were examined in vitro using diverse calcification assays, ex vivo by using the murine aortic ring calcification model, and in vivo after murine erythrocyte membrane injection into neointimal lesions of hypercholesterolemic apolipoprotein E–deficient mi…

Mineral profiles of legumes and fruits through partial least squares energy dispersive X-ray fluorescence

2019

Abstarct Energy dispersive X-ray fluorescence (ED-XRF) has been employed for the determination of mineral elements in 15 varieties of legumes and 14 cherry samples. ED-XRF signals directly obtained from pulverized samples were modelized by partial least squares (PLS) using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) of a selected number of samples, after microwave assisted acid digestion, as reference data. Models were built to predict the concentration of Al, Ca, Cu, Fe, K, Mg, P, Sr and Zn. Average concentrations predicted were 6, 930, 7, 40, 6400, 990, 2100, 4 and 15 μg g−1 for Al, Ca, Cu, Fe, K, Mg, P, Sr and Zn, respectively with relative errors from 7 till 26%. …