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showing 10 items of 980 documents

Marine Pyrrole Alkaloids

2021

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

Aquatic OrganismsQH301-705.5Ecologymarine natural productsPharmaceutical Sciencepyrrole-aminoimidazole alkaloidsReviewBiologyalkaloidsStructure-Activity Relationshipchemistry.chemical_compoundchemistrypyrrolesDrug DiscoveryAnimalspyrrole-imidazole alkaloidsnitrogen heterocyclesbromopyrrolesBiology (General)Pharmacology Toxicology and Pharmaceutics (miscellaneous)PyrroleMarine Drugs
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Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

2020

The mucus layer of the nasopharynx and bronchial epithelium has a barrier function against inhaled pathogens such as the coronavirus SARS-CoV-2. We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro. PolyP is a marine natural product and is abundantly present in marine bacteria. Now, we have approached the in vivo situation by studying the effect of polyP on the human alveolar basal epithelial A549 cells in a mucus-like mucin environment. These cells express mucins as well as the ectoenzymes alkaline phospha…

Aquatic OrganismsSecondary MetabolismVirus AttachmentPharmaceutical ScienceAdenylate kinaseRespiratory MucosaMucin 5ACdigestive systemArticle03 medical and health sciences0302 clinical medicinemucinPolyphosphatesDrug Discoveryotorhinolaryngologic diseasesExtracellularHumansReceptorlcsh:QH301-705.5neoplasmsinnate immunityPharmacology Toxicology and Pharmaceutics (miscellaneous)MUC1030304 developmental biologyA549 cellBiological Products0303 health sciencesBacteriaSARS-CoV-2ChemistryCell growthMucin-1MucinCOVID-19polyphosphaterespiratory systemImmunity Innatedigestive system diseasesSARS-CoV-2 spike proteinADKCell biologyATPlcsh:Biology (General)A549 Cells030220 oncology & carcinogenesishydrogelhuman alveolar cellsMarine Drugs
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Application of Modified Tafel Analysis to the Identification of Corrosion Products on Archaeological Metals Using Voltammetry of Microparticles

2011

Voltammetry of microparticles is applied to the identification of lead corrosion products by means of an essentially non-invasive 'one-touch' technique based on the use of graphite pencil. This methodology permits the mechanical attachment of few nanograms of sample from the surface of lead archaeological artefacts to a paraffin-impregnated graphite electrode, which, upon immersion in aqueous electrolytes, provides distinctive voltammetric responses for litharge and cotunnite- anglesite-, cerusite-based corrosion products. The reported method is applied to the identification of corrosion products in archaeological lead pieces from different Iberian sites in Valencia (Spain). © 2011 WILEY-VC…

Archaeological leadmedia_common.quotation_subjectVoltammetry of microparticlesPINTURAElectrochemistryNon-invasive analysisArtCorrosion productsHoardArchaeologyAnalytical Chemistrymedia_common
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Chemical and Microbiological Characterization for PDO Labelling of Typical East Piedmont (Italy) Salami

2015

This study is focused on the characterisation of typical salami produced in Alessandria province (North West of Italy). Seventeen small or medium salami producers from this area were involved in the study and provided the samples investigated. The aim is double and consists in obtaining a screening of the characteristics of different products and following their evolution along ripening. The study involved five types of typical salami that were characterised for aroma components and nutritional features. This approach could provide a basis for a possible PDO or PGI label request. Principal Component Analysis and cluster analysis were used as multivariate statistical tools for data treatment…

Article SubjectVOLATILE COMPOUNDSCHROMATOGRAPHY MASS-SPECTROMETRYBIOGENIC-AMINESData treatmentFATTY-ACID-COMPOSITIONlcsh:ChemistryCHIM/01 - CHIMICA ANALITICALabellingMILANO SALAMIFood scienceDRY FERMENTED SAUSAGESAromaCURED SAUSAGEbiologyChemistrybusiness.industryGeneral Chemistrybiology.organism_classificationBiotechnologyMEAT-PRODUCTSlcsh:QD1-999North westMultivariate statisticalGC-MSbusinessSENSORY ATTRIBUTESJournal of Chemistry
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An Artificial Intelligence–Based Blending of Satellite products across Mediterranean Island of Sicily, Italy using GPM-IMERG V06 Final Run

2022

Precipitation is the key input variable to hydrological models and its monitoring plays a significant role in water resources planning and improving flood and drought forecasting, also under climate change impacts. In recent years, many precipitation satellite products have been developed and released to the public; among these, the Integrated Multi-satellitE Retrievals from Global Precipitation Measurement (IMERG) is designed to address limitations and uncertainties related to traditional methods. The primary purpose of this study is to provide a comprehensive assessment of precipitation estimates retrieved from the IMERG v6 Final Run over the Mediterranean island of Sicily (Italy) at dail…

Artificial IntelligenceSettore ICAR/02 - Costruzioni Idrauliche E Marittime E IdrologiaGlobal Precipitation Measurementsatellite-based precipitation products
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Sentinel-3/FLEX Biophysical Product Confidence Using Sentinel-2 Land-Cover Spatial Distributions

2021

The estimation of biophysical variables from remote sensing data raises important challenges in terms of the acquisition technology and its limitations. In this way, some vegetation parameters, such as chlorophyll fluorescence, require sensors with a high spectral resolution that constrains the spatial resolution while significantly increasing the subpixel land-cover heterogeneity. Precisely, this spatial variability often makes that rather different canopy structures are aggregated together, which eventually generates important deviations in the corresponding parameter quantification. In the context of the Copernicus program (and other related Earth Explorer missions), this article propose…

Atmospheric Science010504 meteorology & atmospheric sciencesComputer sciencevegetation mappingGeophysics. Cosmic physics0211 other engineering and technologiesContext (language use)02 engineering and technologyLand coverearthSentinel-2 (S2)01 natural sciencessentinel-3 (S3)FLEXcharacterizationComputers in Earth SciencesImage resolutionTC1501-1800spatial resolutionBiophysical productsSentinel-3 (S3)021101 geological & geomatics engineering0105 earth and related environmental sciencesRemote sensingQC801-809biophysical productsbiological system modelingSubpixel renderingSpatial heterogeneityOcean engineeringinstrumentsfluorescence EXplorer (FLEX)Spatial ecologyflexible printed circuitssentinel-2 (S2)Spatial variabilityspatial distributionssensor phenomena
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Advances in understanding mineral dust and boundary layer processes over the Sahara from Fennec aircraft observations

2015

Abstract. The Fennec climate programme aims to improve understanding of the Saharan climate system through a synergy of observations and modelling. We present a description of the Fennec airborne observations during 2011 and 2012 over the remote Sahara (Mauritania and Mali) and the advances in the understanding of mineral dust and boundary layer processes they have provided. Aircraft instrumentation aboard the UK FAAM BAe146 and French SAFIRE (Service des Avions Français Instrumentés pour la Recherche en Environnement) Falcon 20 is described, with specific focus on instrumentation specially developed for and relevant to Saharan meteorology and dust. Flight locations, aims and associated met…

Atmospheric Science010504 meteorology & atmospheric sciencesMeteorologyPlanetary boundary layerCONVECTIVE SYSTEMEnvironmental Sciences & EcologyAEROSOL OPTICAL-PROPERTIESMineral dust010502 geochemistry & geophysicsAtmospheric sciences01 natural sciencesCOARSE MODElcsh:ChemistryHaboobDust storm0201 Astronomical and Space SciencesMeteorology & Atmospheric SciencesSatellite imagerySOUTHERN MOROCCO0105 earth and related environmental sciences[PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph]GBScience & TechnologyHEAT LOWAIRBORNE OBSERVATIONSRETRIEVAL PRODUCTSOzone depletionlcsh:QC1-999PARTICLE-SIZEAERONETBoundary layerlcsh:QD1-99913. Climate action[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/ClimatologyPhysical SciencesWEST-AFRICAN MONSOONEnvironmental science0401 Atmospheric SciencesNORTH-ATLANTIC OCEANLife Sciences & Biomedicinelcsh:PhysicsEnvironmental SciencesAtmospheric Chemistry and Physics
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Application of aerosol optical properties to estimate aerosol type from ground-based remote sensing observation at urban area of northeastern China

2015

Abstract Aerosol optical properties were derived from ground-based sunphotometer observations between 2009-2013 at three urban sites of Shenyang, Anshan, Fushun in northeastern China. The annual means for extinction aerosol optical depths (EAOD) at 500 nm were 0.57±0.38, 0.52±0.35, and 0.41±0.31 at Shenyang, Anshan, Fushun, respectively. The corresponding annual means for the extinction Angstrom exponents (EAE) computed for the wavelengths of 440 and 870 nm were 0.86±0.32, 0.86±0.34 and 0.91±0.35, respectively, indicating that urban area of Northeast China were affected by both coarse and fine particles. Hygroscopic growth in summer and incursions of dust aerosols in spring were evidently r…

Atmospheric Sciencegeographygeography.geographical_feature_categoryMeteorologyCoal combustion productsMineral dustUrban areaAtmospheric sciencesAerosolGeophysicsSpace and Planetary ScienceExtinction (optical mineralogy)Environmental scienceAngstromBiomass burningAbsorption (electromagnetic radiation)Journal of Atmospheric and Solar-Terrestrial Physics
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Application of propidium monoazide quantitative PCR for selective detection of live Escherichia coli O157:H7 in vegetables after inactivation by esse…

2012

The use of propidium monoazide (PMA) is enjoying increased popularity among researchers in different fields of microbiology. Its use in combination with real-time PCR (qPCR) represents one of the most successful approaches to detect viable cells. PMA-qPCR has successfully been used to evaluate the efficacy of various disinfection technologies in different microorganisms. Initially, in this study the effect of four essential oils (EOs), cumin, clove, oregano and cinnamon, was evaluated on suspensions of the enterohemorrhagic Escherichia coli O157:H7 by PMA-qPCR, LIVE/DEAD BacLight flow cytometry analysis (LIVE/DEAD-FCM), and plate count. E. coli O157:H7 cells treated with EOs at killing conc…

AzidesMicroorganismFood ContaminationBiologymedicine.disease_causeEscherichia coli O157Real-Time Polymerase Chain ReactionMicrobiologyPolymerase Chain ReactionFlow cytometryMicrobiologyPropidium monoazideOriganumVegetablesmedicineEscherichia coliOils VolatileEscherichia coliIceberg lettucemedicine.diagnostic_testGeneral MedicineContaminationLettuceFlow CytometryDisinfectionReal-time polymerase chain reactionFood productsFood SciencePropidiumInternational journal of food microbiology
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Human Dietary Intake of Organochlorines from Baltic Herring: Implications of Individual Fish Variability and Fisheries Management

2007

This study examines the extent to which Finnish human dietary intake of organochlorines (PCDD/Fs and PCBs) originating from Northern Baltic herring can be influenced by fisheries management. This was investigated by estimation of human intake using versatile modeling tools (e.g., a herring population model and a bioenergetics model). We used a probabilistic approach to account for the variation in human intake of organochlorines originating from the variation among herring individuals. Our estimates were compared with present precautionary limits and recommendation for use. The results show that present consumption levels and frequencies of herring give a high probability of exceeding recom…

Baltic StatesTime FactorsGeography Planning and DevelopmentFishingFisheriesFood ContaminationBiologyDioxinsRisk AssessmentHerringFish ProductsHydrocarbons ChlorinatedAnimalsHumansEnvironmental ChemistryFinlandRisk ManagementEcologyDietary intakeFishesGeneral MedicineDietFisheryPopulation modelFish <Actinopterygii>Fisheries managementEnvironmental MonitoringRecommended IntakeAMBIO: A Journal of the Human Environment
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