Search results for "Prognostic"
showing 10 items of 316 documents
UiA Accelerated Life Time Bearing Test Rig – Test 3, Variable speed around 50rpm
2021
Vibration data from an accelerated lifetime test of a bearing. Contains raw vibration data and shaft position data. The mean shaft speed is 50rpm with a variation +- 40 rpm. Can be used for fault diagnosis and remaining useful lifetime estimation. Please see "00_ReadMe.pdf" file for more details.
Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study
2022
Abstract Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability and conversion rates have not been extensively studied. Methods This substudy of the prospective RAXO trial included 906 patients recruited between 2011 and 2018. We evaluated repeated centralised resectability assessment, conversion/resection rates and overall survival (OS), according to RAS and BRAF status. Results Patients included 289 with RAS and BRAF wild-type (RAS and BRAFwt), 529 with RAS mutated (RASmt) and 88 with BRAF mutated (BRAFmt) mCRC. Metastatic prevalence varied between the RAS and BRAFwt/RASmt/BRAFmt groups,…
Multidimensional frailty and quality of life: data from the English Longitudinal Study of Ageing
2022
Abstract Purpose Frailty has been found to be associated with poor quality of life (QoL) in older people, but data available are limited to cross-sectional studies. We therefore aimed to assess the association between multidimensional frailty, determined by Multidimensional Prognostic Index (MPI), with mortality and good QoL expectancy (GQoLE) in a large representative sample of older adults, over 10 years of follow-up. Methods In the English Longitudinal Study of Ageing, using the data from 2004–2005 and 2014–2015, MPI was calculated using a weighted score of domains of comprehensive geriatric assessment, i.e., number of difficulties in activities of daily living (ADL) and instrumental ADL…
The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib
2020
Background and aims The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Methods This multicentric study included a training cohort of 194 HCC patients and three external validation cohorts of 129, 76 and 265 HCC patients treated with Sorafenib, respectively. The PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). Univariate and multivariate analyses were performed to investigate the association between the covariates and the overall survival (OS). Results A PNI cut-off value of 31.3 was established using the ROC an…
Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors
2008
To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta". CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1alpha might act as "chemorepellent" while SDF-1beta might act as "chemorepellent" for CTLs, inducing tumor rejection. The paracrine expression of SDF-1alpha was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the disseminat…
Prognostic indicators in pediatric clinically isolated syndrome
2017
To assess prognostic factors for a second clinical attack and a first disability worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of Multiple Sclerosis (MS) patients. Objective: To assess prognostic factors for a second clinical attack and a first disability-worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods: A cohort of 770 pCIS patients was followed up for at least 10 years. Cox proportional hazard models and Recursive Partitioning and Amalgamation (RECPAM) tree-regression were used to analyze data. Results: In pCIS, female sex and a multifocal onset were risk factors for a second clinical att…
Integrated Production and Predictive Maintenance Planning based on Prognostic Information
2019
International audience; This paper address the problem of scheduling production and maintenance operation in predictive maintenance context. It proposes a contribution in the decision making phase of the prognostic and health management framework. Theprognostics and decision processes are merged and an ant colony optimization approach for finding the sequence of decisions that optimizes the benefits of a production system is developed. A case study on a single machine composed of several components where machine can have several usage profiles. The results show thatour approach surpasses classical condition based maintenance policy.
An integrated framework for risk profiling of breast cancer patients following surgery.
2006
Objective: An integrated decision support framework is proposed for clinical oncologists making prognostic assessments of patients with operable breast cancer. The framework may be delivered over a web interface. It comprises a triangulation of prognostic modelling, visualisation of historical patient data and an explanatory facility to interpret risk group assignments using empirically derived Boolean rules expressed directly in clinical terms. Methods and materials: The prognostic inferences in the interface are validated in a multicentre longitudinal cohort study by modelling retrospective data from 917 patients recruited at Christie Hospital, Wilmslow between 1983 and 1989 and predictin…
VARIABILI GENETICHE, BIOLOGICHE E CLINICHE COME FATTORI PROGNOSTICI DI PROGRESSIONE E SOPRAVVIVENZA NELLA SCLEROSI LATERALE AMIOTROFICA
2014
Questo studio ha riguardato l'analisi di alcune variabili prognostiche e di sopravvivenza nella sclerosi laterale amiotrofica, con particolare riferimento alla caratterizzazione di nuovi geni ed al ruolo di interventi di management.
Serīna proteāzes inhibitora Kazel 1 tipa (SPINK 1) nozīme kolorektālā vēža prognostiskā biomarkerī
2019
Globāli kolorektālais vēzis (KRV) ir otrais visbiežāk sastopamais vēzis starp sievietēm un trešais starp vīriešiem, īpaši attīstītajās valstīs. KRV diagnostikā tiek izmantoti dažādi biomarķieri. Šajā pētījumā galvenā uzmanība tiks pievērsta SPINK1, kas ir pierādījis savu nozīmi gan slimības gaitas, gan prognozes noteikšanā. Ar audzēju saistītais tripsīna inhibitors (TATI) un aizkuņģa dziedzera sekrēcijas tripsīna inhibitors (PSTI) pieder pie proteāzes inhibitoru grupas, ko sauc par serīna peptidāzes inhibitoru Kazal (SPINK). Iepriekš veiktajos pētījumos TATI un PSTI ir bieži dēvēti par SPINK1. Normālos apstākļos SPINK1 tiek ekspresēts daudzos kuņģa-zarnu trakta orgānos, kā piemēram, no aknā…