Search results for "Program"
showing 10 items of 5938 documents
Conclusione
2013
Lack of correlation between apoptosis and DNA single-strand breaks in X-irradiated human peripheral blood mononuclear cells in the course of ageing
1998
The dependence on age of both the basal and the X-radiation-induced levels of apoptosis was examined in human peripheral blood mononuclear cells (PBMC). In the same samples, the base value and the extent of induced DNA single-strand breaks were determined, using a sensitive and fast microplate assay. PBMC were isolated from blood of donors of various age groups (20-30, 40-60 and > 70 years of age) and X-irradiated ex vivo using a 6 MV linear accelerator to give a total exposure of 4 Gy. The mean basal levels of apoptosis in PBMC from donors in the 40-60 year age group and the > 70 year age group were found to be only slightly higher (by 20-10%) compared to that of the 20-30 year age group, …
Oxidative Stress and the Epigenetics of Cell Senescence: Insights from Progeroid Syndromes.
2019
Background: Cell senescence constitutes a critical process to respond to a variety of insults and adverse circumstances. Senescence involves the detention of DNA replication and cell proliferation, and hence, genetic programs associated with DNA damage response, chromosome stability, chromatin rearrangement, epigenetic reprogramming, and cell cycle are tightly linked to the senescent phenotype. Although senescence increases with age, the real implication of senescence regulation in the progress of aging in humans is largely discussed. In this context, reactive oxygen species (ROS) accumulation has also been postulated to play a critical role in cell homeostasis, aging processes, and contro…
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
2020
B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways…
Computer-aided synthesis of complex pump and valve operations
1988
Abstract Process plant operators often have to synthesize sequences of valve and pump operations. On large plants there may be so many possible pipe routes and vessels that it is not practical to provide a priori computer support for every possible operation. The paper describes a program that could form the basis of an operator aid to synthesize appropriate operations from a knowledge of the plant layout and existing pumping operations. The paper concentrates on finding paths through the pipework and on generating a sequence of operations that establishes the path whilst simultaneously satisfying other safety and operating constraints. The paper includes two example problems which were use…
Yet Another New Variant of Szász–Mirakyan Operator
2021
In this paper, we construct a new variant of the classical Szász–Mirakyan operators, Mn, which fixes the functions 1 and eax,x≥0,a∈R. For these operators, we provide a quantitative Voronovskaya-type result. The uniform weighted convergence of Mn and a direct quantitative estimate are obtained. The symmetry of the properties of the classical Szász–Mirakyan operator and of the properties of the new sequence is investigated. Our results improve and extend similar ones on this topic, established in the last decade by many authors.
Lightweight BWT Construction for Very Large String Collections
2011
A modern DNA sequencing machine can generate a billion or more sequence fragments in a matter of days. The many uses of the BWT in compression and indexing are well known, but the computational demands of creating the BWT of datasets this large have prevented its applications from being widely explored in this context. We address this obstacle by presenting two algorithms capable of computing the BWT of very large string collections. The algorithms are lightweight in that the first needs O(m log m) bits of memory to process m strings and the memory requirements of the second are constant with respect to m. We evaluate our algorithms on collections of up to 1 billion strings and compare thei…
Lightweight algorithms for constructing and inverting the BWT of string collections
2013
Recent progress in the field of \{DNA\} sequencing motivates us to consider the problem of computing the Burrows‚ÄìWheeler transform (BWT) of a collection of strings. A human genome sequencing experiment might yield a billion or more sequences, each 100 characters in length. Such a dataset can now be generated in just a few days on a single sequencing machine. Many algorithms and data structures for compression and indexing of text have the \{BWT\} at their heart, and it would be of great interest to explore their applications to sequence collections such as these. However, computing the \{BWT\} for 100 billion characters or more of data remains a computational challenge. In this work we ad…
Generación de fractales a partir del método de Newton
2013
[EN] A large number of fractals known, as Julia fractals and Mandelbrot, can be generated from an iterative method. In this paper we present a virtual laboratory developed as a Graphical User Interface (GUI) of Matlab that allows us to study and visualize in real time the relationship between Newton iterative methods of two variables and the generation of fractals. The main objective is to allow Technical School students in Numerical Computation subjects to acquire the skills to generate fractals and interpret their plots in terms of the convergence or divergence speed of the sequence of iterated.
Optimal implementation of neural activation functions in programmable logic using fuzzy logic
2006
Abstract This work presents a methodology for implementing neural activation function in programmable logic using tools from fuzzy logic. This methodology will allow implementing these intrinsic non-linear functions using comparators and simple linear modellers, easily implemented in programmable logic. This work is particularized to the case of a hyperbolic tangent, the most common function in neural models, showing the excellent results yielded with the proposed approximation.