Search results for "Program"
showing 10 items of 5938 documents
Totalitarismo y lenguaje: el campo de concentración como espacio multilingüe y la figura del intérprete concentracionario
2020
espanolEn este trabajo se examinan las relaciones entre el poder absoluto y el lenguaje. Los campos de concentracion del regimen nacionalsocialista se entienden como el espacio donde se materializa la maxima expresion del totalitarismo. Al convertirse en sociedades forzadamente multilingues desde el inicio de la guerra, la lengua alemana puede convertirse, mas que nunca, en un instrumento mas de opresion al servicio del sistema: se deforma para convertirse practicamente en un protolenguaje violento yrudimentario, y su conocimiento por parte de los reclusos se relaciona siempre con las perspectivas de supervivencia. Ademas, se desarrolla una lengua franca que incorpora rasgos de varios idiom…
Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities
2020
Although improvement in early diagnosis and treatment ameliorated life expectancy of cancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancer therapies stems from the refractoriness of a subpopulation of cancer cells—termed cancer stem cells (CSCs)—which is endowed with tumor initiation and metastasis formation potential. CSCs are heterogeneous and diverge by phenotypic, functional and metabolic perspectives. Intrinsic as well as extrinsic stimuli dictated by the tumor microenvironment (TME)have critical roles in determining cell metabolic reprogramming from glycolytic toward an oxidative phenotype and vice versa, allowing cancer cells to th…
Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options
2019
The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, and a quiescent state. Neuroblastoma (NB) is considered a neuroendocrine tumor and is the most common extracranial neoplasm in children. NB pathogenesis has frequently been associated with epigenetic dysregulation and a failure to implement a differentiation program. The origin, characteristics, and isolation of the CSC subpopulation in NB are still incompletely understood, des…
Colorectal Cancer Stem Cells and Cell Death
2011
Nowadays it is reported that, similarly to other solid tumors, colorectal cancer is sustained by a rare subset of cancer stem-like cells (CSCs), which survive conventional anticancer treatments, hanks to efficient mechanisms allowing escape from apoptosis, triggering tumor recurrence. To improve patient outcomes, conventional anticancer therapies have to be replaced with specific approaches targeting CSCs. In this review we provide strong support that BMP4 is an innovative therapeutic approach to prevent colon cancer growth increasing differentiation markers expression and apoptosis. Recent data suggest that in colorectal CSCs, protection from apoptosis is achieved by interleukin-4 (IL-4) a…
Cell Stress, Metabolic Reprogramming, and Cancer
2018
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis (1). Mitochondria, beyond being the site of aerobic respiration, are at the crossroads of a variety of metabolic and signaling pathways resulting key regulatory organelles in cell life and death decision. Thus, it is no surprise that genomic, functional, and structural mitochondrial alterations have been associated with cancer and that mitochondria have become a pharmacological target in cancer…
Il governo del capitale intellettuale attraverso il raccordo tra modelli contabili e di System Dynamics. Una prospettiva di programmazione e controll…
2004
Il presente scritto tenta di far luce sul tema del capitale intellettuale in una prospettiva economico-aziendale, focalizzando in particolare il concetto di governo della conoscenza aziendale. La tesi sostenuta dagli autori è che i processi inerziali di sviluppo e declino della conoscenza non devono essere astrattamente ignorati, relegando l’area Organizzazione e Sistemi al rango di centro di spesa discrezionale. Questa semplicistica prospettiva di analisi può indurre il management all’adozione di politiche miopi, che portino cioè a rinviare investimenti necessari in sviluppo della conoscenza, con l’unico obiettivo di non deprimere i risultati reddituali di breve andare. A tal riguardo, si …
A hardware skin-segmentation IP for vision based smart ADAS through an FPGA prototyping
2017
International audience; In this paper we presents a platform based design approach for fast HW/SW embedded smart Advanced Driver Assistant System (ADAS) design and prototyping. Then, we share our experience in designing and prototyping a HW/SW vision based smart embedded system as an ADAS that helps to increase the safety of car's drivers. We present a physical prototype of the vision ADAS based on a Zynq FPGA. The system detects the fatigue state of the driver by monitoring the eyes closure and generates a real-time alert. A new HW/SW codesign skin segmentation step to locate the eyes/face is proposed. Our presented new approach migrates the skin segmentation step from processing system (S…
Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: the modulation of LDL size and subclasses in high-risk patients.
2007
Increasing evidence suggests that the quality-rather than just the quantity-of low-density lipoproteins (LDLs) exerts a great influence on cardiovascular risk. LDLs comprise multiple subclasses with discrete size and density, and different physicochemical composition, metabolic behaviors, and atherogenicity. Individuals generally cluster into 2 broad subgroups. Most have a predominance of large LDLs, and some have a higher proportion of small particles. Small, dense LDLs are good predictors of cardiovascular events and progression of coronary artery disease. Their predominance has been accepted as an emerging cardiovascular risk factor by the National Cholesterol Education Program Adult Tre…
"Młodzi na progu" - propozycja kerygmatyczno-mistagogicznego przygotowania do sakramentu bierzmowania
2017
Katecheza inicjacyjna obejmuje różne formy nauczania i wychowania prowadzące do przygotowania do przyjęcia sakramentów wtajemniczenia chrześcijańskiego. Ten rodzaj katechezy jest realizowany w ramach programu Młodzi na progu jako materiał do pracy z młodymi ludźmi przygotowującymi się do sakramentu bierzmowania w swoich parafiach. Jest to swoisty sposób by odpowiedzieć na pytanie: Jak pomóc bierzmowanym pozostać w Kościele i być Kościołem? Zasadniczym celem programu jest zachęcenie uczestników spotkań formacyjnych do pracy nad własnym rozwojem, zarówno intelektualnym, jak i duchowym. W tym programie najbardziej dominującymi aspektami są aspekty egzystencjalne, kerygmatyczne i mistagogiczne.…
On Language Adequacy
2015
Abstract The paper concentrates on the problem of adequate reflection of fragments of reality via expressions of language and inter-subjective knowledge about these fragments, called here, in brief, language adequacy. This problem is formulated in several aspects, the most general one being: the compatibility of the language syntax with its bi-level semantics: intensional and extensional. In this paper, various aspects of language adequacy find their logical explication on the ground of the formal-logical theory of syntax T of any categorial language L generated by the so-called classical categorial grammar, and also on the ground of its extension to the bi-level, intensional and ex- tensio…