Search results for "Promoters"

showing 7 items of 17 documents

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
researchProduct

INTER-ORGANIZATIONAL INNOVATION PROMOTERS IN SMALL, KNOWLEDGE-INTENSIVE FIRMS

2009

This paper examines the relationship between external relations and innovation in small, knowledge-intensive Norwegian firms. Our findings indicate that external relations are beneficial for innovation. The analysis shows that it is necessary to treat innovation as more than a concept. Our independent variables related differently to product innovation, process innovation, and market innovation.We found that market participation in product development has a positive impact on product, process and market innovation. We also found that top management interaction with other firms had a positive effect on market innovation and that top management interaction with external R&D had a positive…

VariablesProcess (engineering)Product innovationbusiness.industryStrategy and Managementmedia_common.quotation_subjectInnovation managementContext (language use)Inter organizationalInnovation innovation promoters external relations small knowledge-intensive firms NorwayManagement of Technology and InnovationNew product developmentProduct (category theory)BusinessBusiness and International ManagementMarketingIndustrial organizationmedia_commonInternational Journal of Innovation Management
researchProduct

Biologically active organic compounds, especially plant promoters, in algae extracts and their potential application in plant cultivation

2015

Scientific efforts taken during the past decades undoubtedly have proven that algae are organisms wealthy in various chemical substances such as carbohydrates, proteins, and minerals, as well as polysaccharides, polyphenols, phlorotannins, pigments, unsaturated fats, sterols, and of course growth promoting substances like phytohormones. It is noteworthy that among the many biologically active compounds obtained from seaweeds, plant hormones seem to be the most essential for enhancing the growth and development of crop plants. This fact is well reflected in over 60 years of the long history of controlled application of algae origin products as natural fertilizers in crop production. Neverthe…

application in plant cultivationalgal extractsplants' growth promotersextractionchemical compositionplant hormones
researchProduct

Biologically active compounds in algae and their application in plant growth stimulation

2016

In recent years the bioactive substances of natural origin gained more and more interest. Among such substances, the compounds isolated from microalgae and seaweeds, mainly the polyphenols, polysaccharides, plant hormones, pigments and fatty acids, an find an application in many industries, particularly in medicine, pharmaceutics, cosmetics and agriculture. Biostimulants from seaweeds have been used and manufactured for years, giving confirmation of its effectiveness in field trials, enhancing the growth of crops giving better yields. Nowadays, the legislation processes are more difficult and intricate, so it is harder to register new products. Everyone put more attention on the answers for…

biostimulantsbioactive compounds in algaeplant hormonesseaweeds extractsplant growth promoters
researchProduct

Multiple directorships of corporate boards and firm performance in India

2017

The purpose of the paper is to investigate, first, the association between multiple directorship assignments (busyness) undertaken by corporate directors and firm performance, second, whether endogenously determined limits of multiple directorships, highlighting the ownership structure and other institutional settings, explain the above association better than those by exogenously mandated by regulators and third, the association between the nature of busyness and firm performance. The study develops measures of busyness in the light of the agency and resource dependence theories. The spline regression technique is applied in order to reflect institutional settings of a large sample and sub…

omistajaohjaushallitukset (yhdistykset ja yritykset)kontrollimultiple directorshipscorporate governanceResource Dependence Theoryjohtokunnatpromotersownershipagenttiteoriaboard of directors
researchProduct

OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS

2018

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

oxadiazoles read through promoters TRIDs Cystic Fibrosis genetic diseases nonsense mutations premature termination codons drugs
researchProduct

Import and impact : characterization of parvovirus-nucleus interactions

2016

tumakuljetusreseptoritviruksetkromatinisaatiomodification of nuclear architecturetumahuokosetcanine parvoviruspromotersnuclear transportDNApromoottoritinfektiotchromatinizationnuclear pore complextumaproteiinitparvovirukset
researchProduct