Search results for "Proof of Concept"
showing 10 items of 41 documents
Dynamic railroad inspection using the laser-air hybrid ultrasonic technique
2006
Laser-Air Hybrid Ultrasonic Technique (LAHUT) combines laser generation with air-coupled detection of ultrasound. The technique is non-contact and has the characteristic of operating from remote distances. Acoustic wave laser-generation apparatus can be metres away from the interrogated surface while air-coupled detection standoff can be on the order of several centimetres. The technique has the unique capability of interrogating structural materials in their true industrial environment. Dynamic tests are performed on parts with complex geometry, limited accessibility and curved surfaces. Also, dark and rough finish surfaces, which significantly reduce the efficiency of optical detection te…
Laser-air hybrid ultrasonic technique for dynamic railroad inspection applications
2005
The Laser-Air Hybrid Ultrasonic Technique (LAHUT) combines laser generation with air-coupled detection of ultrasound. The technique is non-contact and has the characteristic of operating from remote distances. Acoustic wave laser-generation apparatus can be metres away from the interrogated surface, while air-coupled detection stand-off can be on the order of several centimetres. The technique has the unique capability of interrogating structural materials in their true industrial environment. Dynamic tests are performed on parts with complex geometry, limited accessibility and curved surfaces. Also, dark and rough finish surfaces, which significantly reduce the efficiency of optical detect…
Proof of concept of wayside railroad wheel inspection using a laser-air hybrid ultrasonic technique
2003
Non-destructive inspection of railroad wheels is performed in maintenance shops, where wheels are removed and inspected individually. No technique is yet available to the railroad industry to perform wayside inspections of wheels on a moving train. The characteristics of laser and air-coupled ultrasound are discussed to justify the use of a laser-air hybrid ultrasonic technique. Laser generation of ultrasound is combined with air-coupled detection to provide a flexible non-contact and remote technique that would enable the railroad industry to perform wayside inspections of moving railroad wheels. The present paper describes Proof of Concept set-up and results of the experiments performed a…
HL7 FHIR with SNOMED-CT to Achieve Semantic and Structural Interoperability in Personal Health Data: A Proof-of-Concept Study
2022
Heterogeneity is a problem in storing and exchanging data in a digital health information system (HIS) following semantic and structural integrity. The existing literature shows different methods to overcome this problem. Fast healthcare interoperable resources (FHIR) as a structural standard may explain other information models, (e.g., personal, physiological, and behavioral data from heterogeneous sources, such as activity sensors, questionnaires, and interviews) with semantic vocabularies, (e.g., Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT)) to connect personal health data to an electronic health record (EHR). We design and develop an intuitive health coaching (eCoach…
Categorical Modeling Method, Proof of Concept for the Petri Net Language
2019
Modeling increases the importance of processes significantly, but also imposes higher requirements for the accuracy of process specifications, since an error in the design of a process may only be discovered after it already produces large cumulative losses. We believe that modeling tools can help build better models in a shorter time. This inevitably results in the need to build formal models that can be theoretically verified. A category as well as a model is a mixture of graphical information and algebraic operations. Therefore, category language seems to be the most general to describe the models. The category theory offers an integrated vision of the concepts of a model, and also provi…
Association Between Serum Levels of Neurofilament Light Chains and Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis.
2021
INTRODUCTION: Serum biomarkers for the diagnosis of minimal hepatic encephalopathy (MHE) in patients with liver cirrhosis would be desirable. In this proof-of-concept study, we investigated the association between MHE and serum levels of neurofilament light chains (sNfL) in patients with liver cirrhosis. METHODS: sNfL were studied in patients with liver cirrhosis (with or without MHE) and controls (patients with ischemic stroke, transitory ischemic attack, and healthy individuals). MHE was diagnosed using the Psychometric Hepatic Encephalopathy Score. RESULTS: Patients with MHE showed higher sNfL than patients without MHE and controls. In multivariable analyses, higher sNfL were independent…
A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren’s syndrome
2020
Abstract Objectives This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary Sjögren’s syndrome (PSS). Methods Adults with PSS were randomized 1:1 to seletalisib 45 mg/day or placebo, in addition to current PSS therapy. Primary end points were safety and tolerability and change from baseline in EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) score at week 12. Secondary end points included change from baseline at week 12 in EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) score and histological features in salivary …
A Nomogram to Characterize the Severity of Detrusor Overactivity during the Ice Water Test: Description of the Method and Proof of Concept
2017
<b><i>Aims:</i></b> To develop a nomogram with severity categories for detrusor overactivity (DO). <b><i>Methods:</i></b> By conducting ice water tests (IWT) in 55 patients with Parkinson’s disease, we identified criteria to describe characteristics of the detrusor pressure curves: (1) a gradient of Δ<i>pdet</i> over Δt at the maximum detrusor pressure and (2) the area under the curve. In a nomogram, 10 severity categories of DO were established: 1 and 2 were assigned to group A (mild), 3 and 4 to group B (moderate) and 5–10 to group C (severe). <b><i>Results:</i></b> In the nomogram, negative IWT (20) appea…
Transillumination imaging through biological tissue by single-pixel detection
2015
One challenge that has long held the attention of scientists is that of clearly seeing objects hidden by turbid media, as smoke, fog or biological tissue, which has major implications in fields such as remote sensing or early diagnosis of diseases. Here, we combine structured incoherent illumination and bucket detection for imaging an absorbing object completely embedded in a scattering medium. A sequence of low-intensity microstructured light patterns is launched onto the object, whose image is accurately reconstructed through the light fluctuations measured by a single-pixel detector. Our technique is noninvasive, does not require coherent sources, raster scanning nor time-gated detection…
Note: Simultaneous modulation transfer spectroscopy on transitions of multiple atomic species for compact laser frequency reference modules
2018
We present a technique for simultaneous laser frequency stabilization on transitions of multiple atomic species with a single optical setup. The method is based on modulation transfer spectroscopy, and the signals are separated by modulating at different frequencies and electronically filtered. As a proof of concept, we demonstrate simultaneous spectroscopy of the potassium D1, D2 and rubidium D2 transitions. The technique can be extended in principle to other atomic species given the availability of optics and cells and allows the development of versatile and compact frequency reference modules.