Search results for "Propylamine"
showing 10 items of 36 documents
Synthesis and characterization of binuclear μ-oxalato nickel(II), copper(II) and zinc(II) complexes with 3,3′-diamino-N-methyl-dipropylamine or trans…
1999
Abstract New binuclear complexes of the type [(Ni(Medpt)NO3)2ox] (1) (Medpt=3,3′-diamino-N-methyl-dipropylamine, H2ox=oxalic acid), [(Ni(dach)2)2ox]NO3·2H2O (2) (dach=trans-1,2-diaminocyclohexane), [(Cu(Medpt))2ox]X2·yH2O (X=NO3, y=2 2/3 (3); X=ClO4, y=0 (4)) and [(Zn(dach)2)2ox](ClO4)2·2H2O (5) have been prepared and characterized by IR and UV–Vis spectroscopies. Spectroscopic data are consistent with oxalate-bridged structures between six-coordinated (N3O3 or N4O2) Ni(II) (compounds 1 or 2), five-coordinated (N3O2) Cu(II) (compounds 3 and 4) or six-coordinated (N4O2) Zn(II) (compound 5). The crystal structure of [(Cu(Medpt))2ox](NO3)2·2 2/3 H2O (3) has been determined by single-crystal X-…
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased suscepti…
2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and chronic seizure models. However, the mechanism by which Sig1R modulates the excitatory and inhibitory pathways in the brain has not been elucidated. The aim of this study was to compare the susceptibility to seizures of wild type (WT) and Sig1R knockout (Sig1R−/−) mice in intravenous pentylenetetrazol (PTZ) and (+)-bicuculline (BIC) infusion-induced acute seizure and Sig1R antagonist NE-100-induced seizure models. To determine pos…
Beta-adrenergic blocking activity and haemodynamic effects in man of K� 1313, a new beta-adrenergic antagonist
1971
The beta-adrenergic blocking activity and haemodynamic effects of o-[2-hydroxy-3-(isopropylamino)-propoxy]-benzonitril (Ko 1313) have been studied in 22 patients. Antagonism of isoproterenol-induced tachycardia was used as a measure of the beta-adrenergic blocking activity. Ko 1313 1.0 mg had its maximum beta-adrenoceptor blocking effect 5–30 min after intravenous injection. Ko 1313 10.0 mg produced maximum betablockade 1–4 h after oral administration. 1.0 mg Ko 1313 injected intravenously had approximately the same beta-adrenergic blocking effect as 1.0 mg propranolol also given intravenously. After intravenous administration Ko 1313 was 3–4 times as potent as the same dose given orally. A…
Darstellung und H2-agonistische Aktivität alkylsubstituierter 3-(Imidazol-4-yl)propylguanidine Synthesis and H2-Agonistic Activity of Alkyl-3-(imidaz…
1987
Derivate des 3-(Imidazol-4-yl)propylguanidins mit einem Methyl- oder einem 2-(Ethylthio)ethyl-Substituenten2) an der Guanidin-Gruppe weisen am H2-Rezeptor des Meerschweinchenvorhofs nur 10–20% der Histaminaktivitat auf. Dagegen fuhrt die Substitution mit der H2-affinen 2-[(5-Methylimidazol-4-yl) methylthio]ethyl-Gruppierung zu Impromidin, einem hochpotenten H2-Agonisten.
Determination of aliphatic amines in water by liquid chromatography using solid-phase extraction cartridges for preconcentration and derivatization
2001
Bond Elut C18 solid-phase extraction cartridges were used for preconcentration and pre-column derivatization with 3,5-dinitrobenzoyl chloride (DNB) of aliphatic amines in water. Conditions for analyte preconcentration and derivatization (including the volume of sample, concentration of reagent, time of reaction and pH) were investigated, using ethylamine, isopropylamine and dimethylamine as model compounds. On the basis of these studies, a rapid and sensitive method for the determination of aliphatic amines in water is presented. The analytes are retained and purified on the cartridges and then derivatized and desorbed by drawing in succession the DNB solution and acetonitrile. The collecte…
A solid device based on doped hybrid composites for controlling the dosage of the biocide N-(3-aminopropyl)-N-dodecyl-1,3-propanediamine in industria…
2015
A colorimetric composite device is proposed to determine the widely used biocide N-(3-aminopropyl)-N-dodecyl-1,3-propanediamine (ADP).This sensing device is based on a film of 1,2-Naphthoquinone-4-sulfonate (NQS) embedded into polydimethylsiloxane-tetraethylortosilicate-SiO2 nanoparticles composite (PDMS-TEOS-SiO2NPs). Semiquantitative analysis can be performed by visual inspection. Digitalized image or diffuse reflectance (DR) measurements can be carried out for quantitative analysis. Satisfactory detection limit (0.018%, w/v) and relative standard deviations <12% were achieved. The proposed device has been applied for the determination of ADP in detergent industrial formulations with reco…
The toxicity of Roundup® 360 SL formulation and its main constituents: Glyphosate and isopropylamine towards non-target water photoautotrophs
2010
The toxicity of commercial formulation of Roundup® 360 SL, widely used, nonselective herbicide and its main constituents, glyphosate (PMG), equimolar (1:1) isopropylamine salt of glyphosate (GIPA) and isopropylamine (IPA) was examined towards eight aquatic microphotoautotrophs; seven cyanobacterial strains representing either saline or freshwater communities, and common eukaryotic algae Chlorella vulgaris Beijerinck. Autotrophs were cultured 21 days in their appropriate standard media supplemented with various amounts of Roundup®, glyphosate, GIPA and IPA. The determination of the growth of examined photoautotrophs was performed by time-course measurements of total chlorophyll content in ex…
Detector supports: application to aliphatic amines in wastewater
2005
Abstract Solid support assisted derivatization coupled to diffuse reflectance spectroscopy (DRS) was proposed and proved useful for the detection and quantification of aliphatic amines in water as an example. Dabsyl chloride (DBS), ninhydrin and sodium 1,2-naphtoquinone 4-sulphonate (NQS) were assayed as derivatization reagents. C 18 and SDB-XC disks and C 18 cartridges were tested for amine retention and after that derivatization. The decrease of the orange colour of dabsyl chloride on SBD-XC disks produced by the formation of its derivative with methylamine in the support (10 min at 100 °C) allowed the selective determination of the amine at concentration level equal or higher than 0.5 mg…
Evaluation of enantioselective binding of propanocaine to human serum albumin by ultrafiltration and electrokinetic chromatography under intermediate…
2011
Abstract Stereoselectivity in protein binding can have a significant effect on the pharmacokinetic and pharmacodynamic properties of chiral drugs. In this paper, the enantioselective binding of propanocaine (PRO) enantiomers to human serum albumin (HSA), the most relevant plasmatic protein in view of stereoselectivity, has been evaluated by incubation and ultrafiltration of racemic PRO–HSA mixtures and chiral analysis of the bound and unbound fractions by electrokinetic chromatography using HSA as chiral selector. Experimental conditions for the separation of PRO enantiomers using HSA as chiral selector and electrokinetic chromatography have been optimised. Affinity constants and protein bi…
Evaluation of C18 adsorbent cartridges for sampling and derivatization of primary amines in air
2004
Abstract The sampling efficiency of C18 solid-phase extraction cartridges was investigated for methylamine, ethylamine, propylamine, butylamine and pentylamine, in air. Determination of these analytes was based on derivatization with o-phthaldialdehyde–N-acetylcysteine (OPA–NAC) on the solid support and fluorescence detection at λexcitation=330 nm and λemission=440 nm of the eluted derivatives. The calibration model derived from aqueous standards was statistically comparable with the calibration model for air standards. Aqueous amines can be used as standards. The method was useful for calculating short-term exposure limits (STEL). A sampling time of 15 min at 30 ml min−1 was employed. Good…