Search results for "Propylene"

showing 10 items of 285 documents

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

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In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
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Determination of phenolic antioxidants additives in industrial wastewater from polypropylene production using solid phase extraction with high-perfor…

2019

Abstract This paper describes a new method for the effective extraction of the residues of five synthetic phenolic antioxidants (AOs): Ditertbutylphenol (DTF), Irganox 1010, Irganox 1076, Ethanox 330 and Cyanox 1790, from industrial water produced during the polypropylene (PP) deodorization process. In the deordorization process, PP is stored in a column for an average time of four hours and exposed to nitrogen and water vapor to remove inflammable compounds which may generate atypical odors in the PP. The samples of interest were taken in the desorber, followed by cleansing and pre-concentration using modified styrene divinylbenzene polymer cartridges. Liquid chromatography was performed w…

Industrial WasteWastewater010402 general chemistryPolypropylenes01 natural sciencesBiochemistryHigh-performance liquid chromatographyAntioxidantsAnalytical ChemistryStyreneIndustrial wastewater treatmentchemistry.chemical_compoundPhenolsLimit of DetectionSolid phase extractionChromatography High Pressure LiquidDetection limitChromatographyChemistry010401 analytical chemistryOrganic ChemistryExtraction (chemistry)Solid Phase ExtractionReproducibility of ResultsGeneral MedicineContaminationDivinylbenzene0104 chemical sciencesCalibrationWater Pollutants ChemicalJournal of chromatography. A
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Slow and fast methyl group rotations in fragile glass-formers studied by NMR

2000

Abstract The spin-lattice relaxation times of the selectively ring deuterated, fragile glass-formers propylene carbonate and toluene were compared with those measured for species which were specifically labeled at the methyl groups. It was found that the dynamics of the CD 3 group is strongly decoupled from that associated with the primary response of toluene, while for propylene carbonate the degree of decoupling is relatively weak. The experimental results could be described successfully using a model which takes into account the ring dynamics as well as those of the methyl group.

Inorganic chemistryRelaxation (NMR)Primary responseGeneral Physics and AstronomyRing (chemistry)Toluene530Condensed Matter::Disordered Systems and Neural NetworksCondensed Matter::Soft Condensed MatterCrystallographychemistry.chemical_compoundchemistryDeuteriumGroup (periodic table)Propylene carbonatePhysical and Theoretical ChemistryPhysics::Chemical PhysicsMethyl group
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Binding of Short Alkyl Chain Surfactants to the (Ethylene oxide)13−(Propylene oxide)30−(Ethylene oxide)13and (Ethylene oxide)75−(Propylene oxide)30−(…

2002

The enthalpy of transfer (ΔHt) of neutral copolymers, at a fixed and low concentration ca. 10-3 mol kg-1, from water to the aqueous surfactant solutions as a function of the surfactant concentration (fSmS) was determined at 25 °C. The surfactants studied are sodium octanoate, sodium decanoate, N-octylpyridinium chloride (OPC), and N,N-dimethyloctylamine-N-oxide (ODAO). The copolymers are (ethylene oxide)13−(propylene oxide)30−(ethylene oxide)13 (L64) and (ethylene oxide)75−(propylene oxide)30−(ethylene oxide)75 (F68). The two copolymers show different hydrophilic−hydrophobic ratios, the larger being for F68. As a general feature, the shape of the ΔHt vs fSmS curve depends on the nature of t…

Isothermal microcalorimetrychemistry.chemical_classificationAqueous solutionPolymers and PlasticsEthylene oxideOrganic ChemistryInorganic chemistryChlorideInorganic Chemistrychemistry.chemical_compoundchemistryPulmonary surfactantMaterials ChemistrymedicineCopolymerPropylene oxideAlkylmedicine.drugMacromolecules
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Small Angle Neutron Scattering, X-ray Diffraction, Differential Scanning Calorimetry, and Thermogravimetry Studies to Characterize the Properties of …

2009

Nanocomposites based on laponite RD and (ethylene oxide)98(propylene oxide)67(ethylene oxide)98 (F127)triblock copolymer or poly(ethylene) glycol 2000 (PEG2000) were prepared by using the melting method. Small-angle neutron scattering and the X-ray diffraction experiments provided insights into the organization of the laponite RD dispersed in the macromolecular matrix over a wide length scale. SANS data analysis by means of a fractal law evidenced the formation of clusters of laponite RD at long correlation distance. The single laponite RD particles and the lamellar structure of F127 were described in the shorter length scale. Finally, the crystalline structure of the macromolecule was obse…

Length scaleTGAMaterials scienceEthylene oxidenanocompositepoly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide)SANSXRDAnalytical chemistrypoly(ethylene)glycol 2000laponite RDNeutron scatteringSmall-angle neutron scatteringSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsDSCThermogravimetrychemistry.chemical_compoundGeneral EnergyDifferential scanning calorimetrychemistryX-ray crystallographyLamellar structurePhysical and Theoretical Chemistry
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Temperature and concentration effects on supramolecular aggregation and phase behavior for poly(propylene oxide)–b-poly(ethylene oxide) –b-poly(propy…

2011

The micro- and mesoscopic structure of reverse Pluronic 25R4 in aqueous mixtures has been studied by SANS, SAXS and shear rheology. These techniques have been able to give a deep insight into the complex structure of the system phase diagram, that includes an isotropic water-rich liquid phase L(1), and liquid crystalline phases with hexagonal, E, or lamellar order, D. Particular attention has been paid to the isotropic water-rich phase L(1), which has a large stability region in the temperature-composition phase diagram. This region is crossed by a large "cloudy zone". Below it, namely at low temperature and composition, SANS data show the presence of polymer unimers in a gaussian coil conf…

Macromolecular SubstancesSurface PropertiesTemperatureWaternanoaggregateReverse Pluronic Lyotropic Phases Micellar Aggregates Defects Packed Vesciclesphase diagramPolyethylene GlycolsSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsBiomaterialsColloid and Surface Chemistryco-block polymerPropylene GlycolsSettore CHIM/02 - Chimica Fisica
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Pegylated nanoparticles based on a polyaspartamide. Preparation, physico-chemical characterization and intracellular uptake

2006

Nanoparticles with different surface PEGylation degree were prepared by using as starting material alpha,beta-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA). PHEA was functionalized with a PEG amino-derivative for obtaining PHEA-PEG(2000) copolymer. Both PHEA and PHEA-PEG(2000) were derivatized with methacrylic anhydride (MA) for obtaining poly(hydroxyethylaspartamide methacrylated) (PHM) and poly(hydroxyethylaspartamide methacrylated)-PEGylated (PHM-PEG(2000)), respectively. Nanoparticles were obtained by UV irradiation of an inverse microemulsion, using as internal phase an aqueous solution of PHM alone or of the PHM/PHM-PEG(2000) mixture at different weight ratio and as external phase a m…

Magnetic Resonance SpectroscopyPolymers and PlasticsUltraviolet RaysNanoparticleMethacrylic anhydrideBioengineeringPolyethylene GlycolsBiomaterialschemistry.chemical_compoundMicroscopy Electron TransmissionPEG ratioPolymer chemistrySpectroscopy Fourier Transform InfraredMaterials ChemistryZeta potentialHumansMicroemulsionParticle SizeNanoparticlesalphabeta-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA)methacrylic anhydride.Aqueous solutionchemistryPropylene carbonatePEGylationMethacrylatesNanoparticlesK562 CellsPeptidesNuclear chemistry
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Deep seroma after incisional hernia repair. Case reports and review of the literature.

2015

Wound-related complications are common after incisional hernia repair with mesh; seroma formation is the most frequent problem. The formation of a deep seroma has been rarely reported in the literature.In one year, September 2012-2013, 136 patients underwent surgery for incisional hernia repair, both elective and urgent.The following complications were observed: one dislocation of polypropylene prosthesis, a massive relapsed seroma and two deep seromas described in this article. A 63- years-old female underwent open incisional hernia repair with an intraperitoneal PTFE patch. She developed recurrent seroma under the mesh drained percutaneously, and finally the prosthesis was removed. A 72- …

MaleDeep serum incisional hernia intraperitoneal meshMiddle AgedSurgical MeshPolypropylenesImaging Three-DimensionalPostoperative ComplicationsSeromaHumansIncisional HerniaSurgical Wound InfectionFemaleTomography X-Ray ComputedPolytetrafluoroethyleneDevice RemovalHerniorrhaphyAged
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FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.

2011

Background The contribution of neuroinflammation and specifically brain lymphocyte invasion is increasingly recognised as a substantial pathophysiological mechanism after stroke. FTY720 is a potent treatment for primary neuroinflammatory diseases by inhibiting lymphocyte circulation and brain immigration. Previous studies using transient focal ischemia models showed a protective effect of FTY720 but did only partially characterize the involved pathways. We tested the neuroprotective properties of FTY720 in permanent and transient cortical ischemia and analyzed the underlying neuroimmunological mechanisms. Methodology/Principal Findings FTY720 treatment resulted in substantial reduction of c…

MaleDrugs and DevicesLymphocyteCerebrovascular DiseasesImmunologyNeuroimmunologyIschemialcsh:MedicineBrain EdemaNeuroprotectionProinflammatory cytokineBrain IschemiaBrain ischemiaMiceNeuropharmacologySphingosinemedicine.arteryhemic and lymphatic diseasesmedicineLeukocytesAnimalsLymphoid OrgansLymphocyteslcsh:ScienceStrokeBiologyNeuroinflammationMultidisciplinarybusiness.industryFingolimod HydrochlorideInterleukin-6Tumor Necrosis Factor-alphalcsh:RImmunologic Subspecialtiesmedicine.diseaseMice Inbred C57BLmedicine.anatomical_structureNeurologyPropylene GlycolsImmune SystemImmunologyMiddle cerebral arteryMedicineClinical Immunologylcsh:QbusinessImmunosuppressive AgentsResearch ArticlePLoS ONE
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A New Prosthetic Implant for Inguinal Hernia Repair: Its Features in a Porcine Experimental Model

2011

Even after more than 100 years of inguinal hernia repair, the rate of complications and recurrence remains unacceptably high. In the last decades, few effective advances in surgical technique and materials have been made. The authors see them as minor adjustments in the shape and materials of the prosthetic implants. Still, the underlying genesis of inguinal hernia remains undefined. Based upon this, it seems the surgical repair of inguinal protrusions cannot be based upon the pathogenesis because the etiology to date has not been addressed. Most hernia repairs are performed with some degree of point fixation (sutures/tacks) to stop the mesh from migrating and creating high recurrence rates…

MaleSettore MED/18 - Chirurgia GeneraleTissue ScaffoldsHernia Inguinal Biocompatible materials Prostheses and implants Incorporation Guided tissue regeneration Tissue scaffoldingGuided Tissue RegenerationSwineAnimalsits features in a porcine experimental model [A new prosthetic implant for inguinal hernia repair]Hernia InguinalProstheses and ImplantsA new prosthetic implant for inguinal hernia repair: its features in a porcine experimental modelPolypropylenes
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