Search results for "Prostate"
showing 10 items of 621 documents
Primary Mucinous Adenocarcinoma of the Urinary Bladder with Signet-Ring Cells: Description of an Uncommon Case and Critical Points in Its Management
2016
We present an uncommon case of mucinous adenocarcinoma of the bladder (MAB) with signet-ring cells extensively infiltrating prostate gland and pelvic/retroperitoneal lymph node stations and not responsive to usual systemic chemotherapy regimens. This case highlights the important features of MAB including the pattern of tumor spread, the tendency for initial misdiagnosis, and the importance of immunohistochemical study in order to define its primary origin from the bladder and choose the most appropriate treatment since the beginning.
Anti-angiogenic therapies in prostate cancer.
2012
Prostate cancer (PCa) is the second most common type of cancer among men in Western societies. Once in the castrate-resistant metastatic setting therapeutic options are limited. The importance of angiogenesis in the progression of PCa has been widely reported providing a rationale to test anti-angiogenic compounds for PCa treatment in clinical trials (CTs). However, in spite of the promising results shown in preclinical models and some anti-tumor activity observed in CTs, to date, no angiogenic inhibitor has been approved for use in PCa. This editorial outlines the latest clinical evidence regarding anti-angiogenic therapies in PCa treatment.
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU…
2023
: In this work, we extend the concept of 5-fluorouracil/heme oxygenase 1 (5-FU/HO-1) inhibitor hybrid as an effective strategy for enhancing 5-FU-based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI 1/20 and SI 1/22, in which the two active parent drugs (i. e., 5-FU and an imidazole-based HO-1 inhibitor) were connected through an easily cleavable succinic linker. Experimental hydrolysis rate, and in silico ADMET predictions were indicative of good drug-likeness and pharmacokinetic properties. Novel hybrids significantly reduced the viability of prostate DU145 cancer cells compared to the parent compounds 5-FU and HO-1 inhibitor administered…
Apoptosis induction of essential oils from Artemisia arborescens L. in human prostate cancer cells
2023
Ethnopharmacological relevance: Prostate cancer originates from cells inside a gland, which begin to grow out of control. In the world, prostate cancer is the most common cancer in the male population. New therapeutic strategies are needed for this tumor which still has a high mortality. A. arborescens leaves and aerial parts have various ethnopharmacological uses such as anti-spasmodic, and their decoctions were used to resolve urticaria, neuralgia and several lung diseases. Often this species has been also used to treat different inflammatory-related diseases such as cancer. Aim of the study: In a continuation of our research on essential oils from medicinal plants, we have selected, two …
A probabilistic framework for automatic prostate segmentation with a statistical model of shape and appearance
2011
International audience; Prostate volume estimation from segmented prostate contours in Trans Rectal Ultrasound (TRUS) images aids in diagnosis and treatment of prostate diseases, including prostate cancer. However, accurate, computationally efficient and automatic segmentation of the prostate in TRUS images is a challenging task owing to low Signal-To-Noise-Ratio (SNR), speckle noise, micro-calcifications and heterogeneous intensity distribution inside the prostate region. In this paper, we propose a probabilistic framework for propagation of a parametric model derived from Principal Component Analysis (PCA) of prior shape and posterior probability values to achieve the prostate segmentatio…
Fiziskās aktivitātes inducēto ekstracelulāro vezikulu ietekme uz priekšdziedzera audzēja attīstību žurkās
2022
Priekšdziedzera vēzis (PV) ir viens no biežāk sastopamajiem ļaundabīgā audzēja veidiem vīriešiem, un, lai uzlabotu terapijas efektivitāti un pacientu dzīves kvalitāti, viens no līdzekļiem varētu būt regulāra fiziska aktivitāte. Ekstracelulārās vezikulas (EV) tiek uzskatītas par vienu no būtiskākajiem starpšūnu komunikācijas veidiem, un vairāki pētījumi ir parādījuši, ka to produkcija tiek inducēta fiziskās aktivitātes laikā. Šajā pētījumā tika noteikta fiziskās slodzes laikā veidojušos EV RNS profila izmaiņas, kā arī šo EV ietekme uz PV attīstību metastātiskā žurku PV modelī. Tika atrasti 20 diferenciāli ekspresēti gēni salīdzinot EV RNS saturu pirms un pēc slodzes, un 52 – salīdzinot aktīv…
Hemoglobīna līmeņa izmaiņas pirms un pēc operācijas, salīdzinot laparoskopisku un vaļēju retropubikālu radikālu prostatektomiju
2021
Primāri diagnosticēts prostatas vēzis stabili ieņem pirmo vietu aiz ne-melanocītiskā ādas audzēja vīriešiem ne tikai Latvijā, bet arī Eiropā. 2018.gadā veiktajā pētījumā apstiprinājās, ka prostatas vēzis ieņem pirmo vietu starp visām diagnosticētajām onkoloģiskajām slimībām Eiropā. Prostatas vēža incidence strauji palielinās līdz ar vecumu – ja 40-44 gadu vecumā prostatas vēzis tiek diagnosticēts 9.2 vīriešiem uz 100`000 iedzīvotājiem, tad jau 70-74 gadu vecumā incidence palielinās vairāk kā 100 reizes līdz pat 984.8 vīriešiem uz 100`000 iedzīvotājiem. Pētījuma galvenais mērķis bija noskaidrot vai dažādi operācijas veidi ietekmē intraoperatīvās asiņošanas risku un tādā veidā sekmē lielāku h…
PERFORMANCE OF DIFFUSION KURTOSIS IMAGING FOR CHARACTERIZATION OF PROSTATE LESIONS USING 1.5T MAGNETIC RESONANCE IMAGING SCANNER
2020
The aim of the study is to evaluate the diagnostic performance of apparent diffusion coefficient (ADC) and apparent kurtosis coefficient (Kapp) for the characterization of prostate lesions on 1.5T MRI. This retrospective study included 34 patients with at least one lesion with PI-RADS score≥ 3. Performances of ADC and Kapp were evaluated using the Mann-Whitney U test and receiver operating characteristics curve (AUROC). Lesions with Gleason score≥6 had significantly lower Kapp compared to benign lesions (p=0.025). The ADC-ratio was the only significantly different parameter between GS≥7 and GS=6 lesions (p=0.039). Kapp showed the largest AUROC for the diagnosis of GS≥6 prostate cancers (AUR…
A Non-linear Diffeomorphic Framework for Prostate Multimodal Registration
2011
International audience; This paper presents a novel method for non-rigid registration of prostate multimodal images based on a nonlinear framework. The parametric estimation of the non-linear diffeomorphism between the 2D fixed and moving images has its basis in solving a set of non-linear equations of thin-plate splines. The regularized bending energy of the thin-plate splines along with the localization error of established correspondences is jointly minimized with the fixed and transformed image difference; where, the transformed image is represented by the set of non-linear equations defined over the moving image. The traditional thin-plate splines with established correspondences may p…
Texture Guided Active Appearance Model Propagation for Prostate Segmentation
2010
Fusion of Magnetic Resonance Imaging (MRI) and Trans Rectal Ultra Sound (TRUS) images during TRUS guided prostate biopsy improves localization of the malignant tissues. Segmented prostate in TRUS and MRI improve registration accuracy and reduce computational cost of the procedure. However, accurate segmentation of the prostate in TRUS images can be a challenging task due to low signal to noise ratio, heterogeneous intensity distribution inside the prostate, and imaging artifacts like speckle noise and shadow. We propose to use texture features from approximation coefficients of Haar wavelet transform for propagation of a shape and appearance based statistical model to segment the prostate i…