Search results for "Prostatic Neoplasm"

showing 10 items of 285 documents

Biological aggressiveness evaluation in prostate carcinomas: immunohistochemical analysis of PCNA and p53 in a series of Gleason 6 (3+3) adenocarcino…

2003

We selected 63 prostate tumors with Gleason's grade 6 (3+3), commonly showing both tubular and cribrous patterns. We compared in both patterns the expression of two of the most used biologic markers: PCNA and p53, with the aim to verify the validity of the Gleason's grading system to compare the morphologic grade with biologic aggressiveness and prognostic value. We did not find any statistical difference in the protein immunopositivity, indicating that both patterns could have identical biologic behaviour; then we confirmed the validity of Gleason's system for considering both tubular and cribrous patterns as an intermediate grade of tumoral differentiation. Moreover, we found a linear rel…

MalePathologymedicine.medical_specialtyHistologyProliferative indexBiophysicsStatistical differenceSettore MED/08 - Anatomia PatologicaAdenocarcinomaBiologyP53 MutationProstateProliferative index; Prostate cancerogenesis; Tumoral differentiation; Tumoral prognosis; Cell Biology; Anatomy; Animal Science and Zoology; Developmental BiologyProliferating Cell Nuclear AntigenBiomarkers TumormedicineHumansProstate tumorsIntermediate Gradelcsh:QH301-705.5Tumoral differentiationBiologic markerProstatic NeoplasmsCell BiologyImmunohistochemistryProliferating cell nuclear antigenmedicine.anatomical_structurelcsh:Biology (General)Prostate cancerogenesibiology.proteinImmunohistochemistryTumoral prognosiAnimal Science and ZoologyAnatomyTumor Suppressor Protein p53Developmental BiologyEuropean Journal of Histochemistry
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Is hospital discharge administrative data an appropriate source of information for cancer registries purposes? Some insights from four Spanish regist…

2010

Abstract Background The use of hospital discharge administrative data (HDAD) has been recommended for automating, improving, even substituting, population-based cancer registries. The frequency of false positive and false negative cases recommends local validation. Methods The aim of this study was to detect newly diagnosed, false positive and false negative cases of cancer from hospital discharge claims, using four Spanish population-based cancer registries as the gold standard. Prostate cancer was used as a case study. Results A total of 2286 incident cases of prostate cancer registered in 2000 were used for validation. In the most sensitive algorithm (that using five diagnostic codes), e…

MalePathologymedicine.medical_specialtyPediatricsNeoplasias de la próstataEspañaPopulationMEDLINESensitivity and SpecificityHealth administration:Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms Male::Prostatic Neoplasms [Medical Subject Headings]Prostate cancer:Publication Characteristics::Study Characteristics::Validation Studies [Medical Subject Headings]Research articlemedicineHumansRegistros de hospitalesRegistries:Publication Characteristics::Study Characteristics::Case Reports [Medical Subject Headings]Medical diagnosisDiagnostic Errorseducation:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]education.field_of_studybusiness.industryHealth Policylcsh:Public aspects of medicineCancerProstatic Neoplasms:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Medical Record Linkage [Medical Subject Headings]lcsh:RA1-1270Gold standard (test)medicine.diseaseHospital RecordsPatient DischargeEstudios de validaciónSpainPopulation SurveillanceSistema de registrosDiagnosis codeForms and Records ControlMedical Record LinkageRegistro médico oordinado:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records [Medical Subject Headings]businessAlgorithmsBMC Health Services Research
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Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer

2019

Purpose The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and methods A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results The distribution of γδ T cells …

MalePathologymedicine.medical_specialtyProstate biopsyT-Lymphocyte subsetUrological OncologyBiopsyUrology030232 urology & nephrologylcsh:RC870-923Flow cytometry03 medical and health sciencesProstate cancerLymphocytes Tumor-Infiltrating0302 clinical medicineProstateBiopsymedicineHumansProspective StudiesIntraepithelial LymphocytesAgedNeoplasm gradingmedicine.diagnostic_testbusiness.industryCancerMiddle AgedNeoplastic Cells Circulatinglcsh:Diseases of the genitourinary system. Urologymedicine.diseasePhenotypeImmunologic surveillanceImmunosurveillancemedicine.anatomical_structure030220 oncology & carcinogenesisOriginal ArticleProstatic neoplasmsProstatic neoplasmbusinessT-Lymphocyte subsetsInvestigative and Clinical Urology
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Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade

2007

Reelin is a glycoprotein that plays a critical role in the regulation of neuronal migration during brain development and, since reelin has a role in the control of cell migration, it might represents an important factor in cancer pathology. In this study, 66 surgical specimens of prostate cancer were analyzed for reelin expression by immunohistochemical method. The reelin expression was correlated with Gleason score and individual Gleason patterns. Reelin expression was found in 39% prostate cancers. Stromal tissues, normal epithelial cells and prostate intraepithelial neoplasia (PIN) of any grade around and distant from cancer were always negative for reelin. Reelin was found in malignant …

MalePathologymedicine.medical_specialtyStromal cellCell Adhesion Molecules NeuronalNerve Tissue Proteinsurologic and male genital diseasesGleason Score 6Pathology and Forensic MedicineProstate cancerProstatereelinBiomarkers TumorcancerMedicineHumansReelinGleason scoreneoplasmsAgedAged 80 and overIntraepithelial neoplasiaExtracellular Matrix Proteinsprostatebiologybusiness.industrySerine EndopeptidasesCancerProstatic NeoplasmsMiddle Agedmedicine.diseaseImmunohistochemistryReelin Proteinsurgical procedures operativemedicine.anatomical_structurenervous systembiology.proteinImmunohistochemistrybusiness
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Epithelioid Leiomyoma of the Prostate

1996

We report a case of an unusual mesenchymal tumor of the prostate. Rectal-digital palpation and transrectal ultrasound showed a circumscribed and inhomogeneous tumor within the right prostatic lobe. Surgical treatment consisted of transurethral resection of the right prostatic lobe. On the basis of morphology and immunohistochemical detection of desmin and smooth-muscle-type actin, the diagnosis of an epithelioid leiomyoma was made. This is the first report of this entity in the prostate. A definite prediction of the biological potential is currently not yet possible.

MalePathologymedicine.medical_specialtyUrologyEpithelioid leiomyomaPalpationProstatemedicineHumansUltrasonographyProstatectomyPalpationmedicine.diagnostic_testbusiness.industryUltrasoundProstatic NeoplasmsLeiomyoma EpithelioidBiological potentialMiddle Agedmedicine.diseaseImmunohistochemistrymedicine.anatomical_structureLeiomyomaImmunohistochemistryDesminbusinessEuropean Urology
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Detection of circulating prostate cells by reverse transcriptase-polymerase chain reaction of human glandular kallikrein (hK2) and prostate-specific …

1997

Abstract Objectives To investigate the clinical value of human glandular kallikrein (hK2) reverse transcriptase-polymerase chain reaction (RT-PCR) for detection of prostate cells in circulation and to compare the results with those obtained from prostate-specific antigen (PSA) RT-PCR. Methods We examined peripheral blood (PB) and bone marrow (BM) samples of 13 patients with advanced-stage prostate cancer and 63 patients with clinically localized disease for the presence of circulating prostate cells. An RT-PCR protocol with a two-step amplification cycle and hot-start conditions was used. Results The limit of detection of the PCR portion is similar for PSA and hK2 (5 to 10 copies of the pla…

MalePathologymedicine.medical_specialtyUrologyurologic and male genital diseasesPolymerase Chain ReactionPeripheral blood mononuclear cellProstate cancerAntigenProstateLNCaPHumansMedicineRNA MessengerHuman Glandular Kallikreinbusiness.industryProstatic NeoplasmsProstate-Specific AntigenNeoplastic Cells Circulatingmedicine.diseaseMolecular biologyProstate-specific antigenmedicine.anatomical_structureKallikreinsBone marrowbusinessTissue KallikreinsUrology
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Comparison of Active and Passive Targeting of Docetaxel for Prostate Cancer Therapy by HPMA Copolymer–RGDfK Conjugates

2011

N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer-docetaxel-RGDfK conjugate was synthesized, characterized, and evaluated in vitro and in vivo in comparison with untargeted low and high molecular weight HPMA copolymer-docetaxel conjugates. The targeted conjugate was designed to have a hydrodynamic diameter below renal threshold to allow elimination post treatment. All conjugates demonstrated the ability to inhibit the growth of DU145 and PC3 human prostate cancer cells and the HUVEC at low nanomolar concentrations. The targeted conjugate showed active binding to α(v)β(3) integrins in both HUVEC and DU145 cells, whereas the untargeted conjugate demonstrated no evidence of specific binding. …

MalePolymersMice NudePharmaceutical ScienceAntineoplastic AgentsDocetaxelPharmacologyurologic and male genital diseasesArticleMicechemistry.chemical_compoundProstate cancerstomatognathic systemIn vivoCell Line TumorDrug DiscoveryCopolymermedicineAnimalsMethacrylamideCell ProliferationAcrylamidesChemistryProstatic Neoplasmsmedicine.diseaseIn vitroDocetaxelTargeted drug deliveryMolecular MedicineTaxoidsmedicine.drugConjugateMolecular Pharmaceutics
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Robot-assisted ascending-descending laparoscopic nerve-sparing prostatectomy

2009

MalePostoperative CareProstatectomyLaparoscopic surgerymedicine.medical_specialtymedicine.diagnostic_testProstatectomybusiness.industryUrologymedicine.medical_treatmentProstatic NeoplasmsEndoscopic surgerySurgeryNerve-Sparing ProstatectomyMedical IllustrationmedicineHumansLaparoscopyAnatomy ArtisticLaparoscopybusinessBJU International
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A bioinformatics analysis of Lamin-A regulatory network: a perspective on epigenetic involvement in Hutchinson-Gilford progeria syndrome.

2012

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature aging. HGPS is caused by mutation in the Lamin-A (LMNA) gene that leads, in affected young individuals, to the accumulation of the progerin protein, usually present only in aging differentiated cells. Bioinformatics analyses of the network of interactions of the LMNA gene and transcripts are presented. The LMNA gene network has been analyzed using the BioGRID database (http://thebiogrid.org/) and related analysis tools such as Osprey (http://biodata.mshri.on.ca/osprey/servlet/Index) and GeneMANIA ( http://genemania.org/). The network of interaction of LMNA transcripts has been further analyze…

MalePremature agingcongenital hereditary and neonatal diseases and abnormalitiesAginghgps ceRNA lmna progerinBiologyModels BiologicalEpigenesis GeneticLMNAAdenosine TriphosphateProgeriaDatabases GeneticmedicineHumansGene Regulatory NetworksEpigeneticsGeneticsProgeriaModels Geneticintegumentary systemCompeting endogenous RNAComputational BiologyProstatic Neoplasmsnutritional and metabolic diseasesLamin Type Amedicine.diseaseProgerinChromatinChromatinGeriatrics and GerontologySoftwareLamin
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External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans

2019

[Purpose] To perform a systematic and thorough assessment, using the Uncomplicated and Cancer-Free Control Probability (UCFCP) function, of a broad range of photon prostate cancer RT treatments, on the same scenario (a unique pelvic CT set). UCFCP considers, together with the probabilities of local tumour control (TCP) and deterministic (late) sequelae (NTCP), the second primary cancer risk (SPCR) due to photon and neutron peripheral doses.

MaleProbability assessmentmedicine.medical_treatmentRadiobiological modellingBiophysicsGeneral Physics and AstronomyProstate radiotherapy treatmentNormal tissue complication probabilityTumour control probabilityRadiation protection of the patient030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicinemedicineHumansDosimetryRadiology Nuclear Medicine and imagingConformal radiationProbabilityPhotonsbusiness.industryRadiotherapy Planning Computer-AssistedCancer-FreePhoton radiationProstatic NeoplasmsRadiotherapy DosageGeneral MedicineSecond primary cancermedicine.diseaseRadiation therapySecond primary cancer risk030220 oncology & carcinogenesisRadiotherapy plan optimisationRadiotherapy Intensity-ModulatedRadiotherapy ConformalTomography X-Ray ComputedNuclear medicinebusinessPhysica Medica 66: 88-96 (2019)
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