Search results for "Protein"
showing 10 items of 21431 documents
Use of dietary supplements and dietary behaviour among young people who exercise at gyms
2008
Single Molecule Study of GFP-mut2 Proteins Caged in Trehalose-Water Matrixes: Spatially Inhomogeneous Protein-Water-Sugar Structures
2007
Phasor-FLIM for a direct investigation of Transportan 10 interactions with model membranes
2023
Transportan 10 (TP10), a short and positive charged peptide, belonging to the family of the cell penetrating peptides has gained increasing attention for its antimicrobial and anticancer activity but also for its applications in drug delivery as it is able to translocate therapeutic molecules in cellular environment. Due to the complexity of the phenomena involved in cellular uptake and following processes, which strongly depend on the membrane lipid composition, structural details of the peptide (e.g., charge, hydrophobicity, steric hindrance) and environmental conditions, it is not easy to understand the general rules governing them. Here, we combine spectroscopic techniques and fluoresce…
Elevati livelli di proteina C-reattiva sono predittivi di eventi clinici nei pazienti ipertesi con lesioni carotidee asintomatiche
2006
L’eta’ e gli elevati livelli di proteina C-reattiva e fibrinogeno sono forti predittori di eventi clinici in una popolazione di donne con aterosclero…
2007
Molecular mechanisms underlying proteins-membrane interaction
Proteomics in antitumor research
2006
Proteins are the molecular players of fine-tuned regulatory pathways that underlie the behavior of any cell type. Derangement of this wide protein circuitry has a profound effect on cell life and ultimately contributes to the development of diseases such as cancer. New proteomic technologies are rapidly evolving to define and characterize the nodes of this altered protein network, both inside and outside cancer cells. Hopefully, these technologies will become user-friendly laboratory tools to improve cancer management from early detection to the development of rational and patient-tailored therapeutic strategies.
Transport of Arabidopsis GPI-anchored proteins along the early secretory pathway: Role of GPI-anchor remodelling and p24 proteins
2019
Las proteínas con anclaje GPI son una familia de proteínas que están ancladas a la cara exterior de la membrana plasmática mediante un ancla GPI y se ha visto que juegan un papel clave en plantas. Sin embargo, la maquinaria molecular implicada en el transporte de estas proteínas a la membrana plasmática en plantas es aún desconocida. Las proteínas p24 tienen un papel importante en el control de calidad de proteínas (posiblemente incluyendo las proteínas con anclaje GPI) transportadas entre el Retículo Endoplasmático y el aparato de Golgi. Esta tesis doctoral tiene como objetivo el estudio de la posible implicación de las proteínas p24 en la salida del Retículo Endoplasmático y en la localiz…
Interaction of mushroom tyrosinase with aromatic amines, o-diamines and o-aminophenols
2004
3-Amino-L-tyrosine was found to be a substrate of mushroom tyrosinase, contrary to what had previously been reported in the literature. A series of amino derivatives of benzoic acid were tested as substrates and inhibitors of the enzyme. 3-Amino-4-hydroxybenzoic acid, 4-amino-3-hydroxybenzoic acid and 3,4-diaminobenzoic acid were oxidized by this enzyme, as previously reported for Neurospora crassa tyrosinase, but 4-aminobenzoic acid and 3-aminobenzoic acid were not. Interestingly, 3-amino-4-hydroxybenzoic acid was oxidized five times faster than 4-amino-3-hydroxybenzoic acid, confirming the importance of proton transfer from the hydroxyl group at C-4 position. All compounds inhibited the m…
Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes
2019
Proton diffusion (PD) across biological membranes is a fundamental process in many biological systems, and much experimental and theoretical effort has been employed for deciphering it. Here, we report on a spectroscopic probe, which can be tightly tethered to the membrane, for following fast (nanosecond) proton transfer events on the surface of membranes. Our probe is composed of a photoacid that serves as our light-induced proton source for the initiation of the PD process. We use our probe to follow PD, and its pH dependence, on the surface of lipid vesicles composed of a zwitterionic headgroup, a negative headgroup, a headgroup that is composed only from the negative phosphate group, or…