Search results for "Protocol"
showing 10 items of 1808 documents
Virtual Clinical and Precision Medicine Tumor Boards-Cloud-Based Platform-Mediated Implementation of Multidisciplinary Reviews Among Oncology Centers…
2021
Background Multidisciplinary tumor boards play a pivotal role in the patient-centered clinical management and in the decision-making process to provide best evidence-based, diagnostic, and therapeutic care to patients with cancer. Among the barriers to achieve an efficient multidisciplinary tumor board, lack of time and geographical distance play a major role. Therefore, the elaboration of an efficient virtual multidisciplinary tumor board (VMTB) is a key point to successfully obtain an oncology team and implement a network among health professionals and institutions. This need is stronger than ever during the COVID-19 pandemic. Objective This paper presents a research protocol for an obse…
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
2006
Item does not contain fulltext BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified ac…
Phase I/II trial of capecitabine and oxaliplatin in combination with bevacizumab and imatinib in patients with metastatic colorectal cancer: AIO KRK …
2013
Background: Combined inhibition of platelet-derived growth factor receptor beta signalling and vascular endothelial growth factor promotes vascular normalisation in preclinical models and may lead to increased delivery of chemotherapy to tumour tissue. This phase I/II trial assessed the safety and efficacy of capecitabine plus oxaliplatin (XELOX) plus bevacizumab and imatinib in the first-line treatment of patients with metastatic colorectal cancer. Methods: Two dose levels (I/II) were defined: capecitabine 850/1000 mg m−2 twice daily on days 1–14; oxaliplatin 100/130 mg m−2 on day 1; bevacizumab 7.5 mg kg−1 on day 1; imatinib 300 mg day−1 on days 1–21 every 21 days. The primary study endpo…
Neoadjuvant chemotherapy for stage IIIA-N2 non-small cell lung cancer
2005
Neoadjuvant chemotherapy in potentially resectable stage IIIA-N2 non-small cell lung cancer (NSCLC) has become standard of treatment in the last years. Two randomised pioneer phase III trials conducted with second generation platinum combinations had demonstrated an advantage in survival of induction chemotherapy followed by surgery versus surgery alone. Subsequently, a wide number of phase II studies with third generation platinum-based doublets or triplets have increased the evidence of the activity as well as the good tolerability of this approach. Nowadays, the main topics of ongoing clinical research are to assess the role of induction chemotherapy in early stage disease, and the role …
Semantics driven interaction using natural language in students tutoring
2007
The aim of this work is to introduce a semantic integration between an ontology and a chatbot in an Intelligent Tutoring Systems (ITS) to interact with students using natural language. The interaction process is driven by the use of a purposely defined ontology. In the ontology two types of conceptual relations are defined. Besides the usual relations, which are used to define the domain's structure, another type of relation is used to define the navigation schema inside the ontology according to the need of managing uncertainty. Uncertainty level is related to student knowledge level about the involved concepts. In this work we propose an ITS for the Java programming language called TutorJ…
A literature review of sensor ontologies for manufacturing applications
2013
The purpose of this paper is to review existing sensor and sensor network ontologies to understand whether they can be reused as a basis for a manufacturing perception sensor ontology, or if the existing ontologies hold lessons for the development of a new ontology. We develop an initial set of requirements that should apply to a manufacturing perception sensor ontology. These initial requirements are used in reviewing selected existing sensor ontologies. Additionally, we present our developed sensor ontology thus far that incorporates a refined list of requirements. This paper describes 1) extending and refining the requirements; 2) proposing hierarchical structures for verifying the purpo…
A Survey on Ontology Evaluation Methods
2015
International audience; Ontologies nowadays have become widely used for knowledge representation, and are considered as foundation for Semantic Web. However with their wide spread usage, a question of their evaluation increased even more. This paper addresses the issue of finding an efficient ontology evaluation method by presenting the existing ontology evaluation techniques, while discussing their advantages and drawbacks. The presented ontology evaluation techniques can be grouped into four categories: gold standard-based, corpus-based, task-based and criteria based approaches.
Semi-automatic Derivation of Specific-Domain Ontologies for the Semantic Web
2006
This paper describes an approach for helping in the semi-automatic construction of specific-domain ontology components contained in a digital archive. This proposal for extracting knowledge from digital sources allows users to have a view of this knowledge and visualize specific-domain ontology components that with further processing can be shared with software agents by embedding it into digital archives themselves in the context of the Semantic Web. In particular, we deal with the issue of not constructing the ontology from scratch, our approach helps us to speed up the ontology creation process.
Cardiopulmonary resuscitation in prone position: A scoping review.
2020
Introduction The ongoing pandemic of COVID-19 brought to the fore prone positioning as treatment for patients with acute respiratory failure. With the increasing number of patients in prone position, both spontaneously breathing and mechanically ventilated, cardiac arrest in this position is more likely to occur. This scoping review aimed to summarize the available evidence on cardiopulmonary resuscitation in prone position (‘reverse CPR’) and knowledge or research gaps to be further evaluated. The protocol of this scoping review was prospectively registered on 10th May 2020 in Open Science Framework (https://osf.io/nfuh9). Methods We searched PubMed, EMBASE, MEDLINE and pre-print repositor…
Autonomous agent system using dispatching rules in the negotiation protocol
2002
In this paper, the most important results obtained by the simulated application of autonomous agent paradigms to a. real factory are presented. The classical rules of dispatching are compared with the autonomous agents approach. In particular, the possibility of redesigning the negotiation rules in terms of currency in order to take into account even non-time-related costs is considered. Finally, a new project on the effective application of the autonomous agent system to a test bed, modelling a simplified firm, is proposed.