Search results for "Protocol"

2021

Sand play may be a significant determinant of health and development in early childhood, but systematically synthesised evidence is absent in the literature. The main objective of this study was to present a planned methodology to systematically review, and synthesise, the evidence regarding sand play and its associations with 0–8-year-old children’s health and development. The systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement was registered to PROSPERO (CRD42021253852). Literature searches will be conducted using information from eight electronic databases. Studies will be included when participating children were aged 0–…

High-accuracy extrapolated ab initio thermochemistry. II. Minor improvements to the protocol and a vital simplification

2006

The recently developed high-accuracy extrapolated ab initio thermochemistry method for theoretical thermochemistry, which is intimately related to other high-precision protocols such as the Weizmann-3 and focal-point approaches, is revisited. Some minor improvements in theoretical rigor are introduced which do not lead to any significant additional computational overhead, but are shown to have a negligible overall effect on the accuracy. In addition, the method is extended to completely treat electron correlation effects up to pentuple excitations. The use of an approximate treatment of quadruple and pentuple excitations is suggested; the former as a pragmatic approximation for standard cas…

Single tube optimisation of APOE genotyping based on melting curve analysis

2008

Objectives: To develop and validate a single-tube protocol for APOE genotyping using fluorescent probes. Design and methods: We have designed and validated a hybrid, single-tube, SimpleProbe/FRET probe protocol that takes advantage of the different probe wavelength emissions. Results: Our method offers high quality outcomes, minimum interferences between probe signals and is 100% concordant with the reference protocol. Conclusions: This method is cheaper, faster and more reliable and versatile than other alternatives proposed. © 2008 Elsevier Inc. All rights reserved.

2019

Active aging has been established as a policy goal for aging societies. We define active aging at the individual level as striving for elements of well-being through activities in relation to a person’s goals, functional capacities and opportunities. Increasing evidence suggests that any meaningful activity is beneficial for different aspects of well-being in older people. The aim of the present randomized controlled trial is to test the feasibility and effectiveness of a one-year community-based intervention on active aging. The AGNES intervention aims at increasing older peoples’ participation in self-selected valued activities. The proposed study is a two-arm single-blinded randomized co…

The impact of long-term care needs on the socio-economic deprivation of older people and their families: A scoping review protocol

2021

Abstract BackgroundPopulation ageing, constantly on the increase in all countries worldwide, has long been the object of scientific research from several perspectives, including multi and interdisciplinary approaches. This scoping review aims to investigate the socio-economic consequences of older people’s poor health on their own economic conditions and those of their families. This study aims to: a) map the main concepts that characterise the body of literature pertaining to this issue; b) identify conceptual gaps or unexplored research areas to be addressed; c) delve into the ways of arguing about the difficulties that affect a large number of families with older members to care for, esp…

Adolescents and young adults’ experiences of living with everyday pain: A systematic review protocol of qualitative evidence

2014

Published version of an article in the journal: JBI Database of Systematic Reviews and Implementation Reports. Also available from the publisher at: http://dx.doi.org/10.11124/jbisrir-2014-1570 Open Access The objective of this systematic review is to identify and synthesize the best available evidence from qualitative primary studies on how adolescents and young adults’ experience living with everyday pain. Review question/objective: What are the experiences of adolescents and young adults (AYA) living with everyday pain?

2021

Abstract Terrestrial Essential Climate Variables, known as terrestrial ECVs, are key sources of information for both application- and scientific- oriented research. A large number of global terrestrial ECV products have been derived from satellite observations, and more are forthcoming. To unlock the full potential of these products, end-users need to know their uncertainties and error magnitudes. Due to the lack of conformity among validation strategies, a wide range of validation approaches have been employed to assess the quality of these products, and have resulted in reduced comparability even for the same terrestrial ECV. Addressing this challenge in validation practices requires the …

An Internet-Based Self-Help Program for the Treatment of Fear of Public Speaking: A Case Study

2008

ABSTRACT This article discusses the development of the first totally self-administered online CBT program for the treatment of a specific social phobia (fear of public speaking) called talk to me. The online program includes three parts. The assessment protocol gives the patient information about the problem, including impairment, severity, and the degree of fear and avoidance regarding the main feared situations. The structured treatment protocol ensures that the patient does not skip any steps in the treatment. The treatment protocol is a CBT program that provides exposure to the feared situation using videos of real audiences. Finally, the control protocol assesses treatment efficacy, no…

Psychological interventions for people with histrionic personality disorder

2012

Reason for withdrawal from publication Authors have made no progress with this protocol in over a year due to difficulties with identifying potentially suitable studies. The protocol has been withdrawn. To view the published versions of this article, please click the 'Other versions' tab.

Harmonization of Immune Biomarker Assays for Clinical Studies

2011

Assays that measure a patient's immune response play an increasingly important role in the development of immunotherapies. The inherent complexity of these assays and independent protocol development between laboratories result in high data variability and poor reproducibility. Quality control through harmonization--based on integration of laboratory-specific protocols with standard operating procedures and assay performance benchmarks--is one way to overcome these limitations. Harmonization guidelines can be widely implemented to address assay performance variables. This process enables objective interpretation and comparison of data across clinical trial sites and also facilitates the ide…