Search results for "Protocol"
showing 10 items of 1808 documents
The effects of tasks on integrating information from multiple documents.
2008
The authors examine 2 issues: (a) how students integrate information from multiple scientific documents to describe and explain a physical phenomenon that represents a subset of the information in the documents; and (b) the role of 2 sorts of tasks to achieve this type of integration, either writing an essay on a question requiring integration across texts or answering shorter intratext questions that require students to integrate information within a single text, while superficial and deep comprehension measurements are obtained. Undergraduate students answered 1 of the 2 types of questions, and their reading times were recorded. Half of the sample thought aloud. Results showed that the in…
Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer
2021
The combination of trastuzumab plus pertuzumab plus docetaxel as a first-line therapy in patients with HER2-positive metastatic breast cancer has provided significant clinical benefits compared to trastuzumab plus docetaxel alone. However, despite the therapeutic success of existing therapies targeting HER2, tumours invariably relapse. Therefore, there is an urgent need to improve our understanding of the mechanisms governing resistance, so that specific therapeutic strategies can be developed to provide improved efficacy. It is well known that the tumour microenvironment (TME) has a significant impact on cancer behaviour. Cancer-associated fibroblasts (CAFs) are essential components of the…
SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells
2012
Abstract SAHA, an inhibitor of histone deacetylase activity, has been shown to sensitize tumor cells to apoptosis induced by TRAIL, a member of TNF-family. In this paper we investigated the effect of SAHA/TRAIL combination in two breast cancer cell lines, the ERα−positive MCF-7 and the ERα−negative MDA-MB231. Treatment of MDA-MB231 and MCF-7 cells with SAHA in combination with TRAIL caused detachment of cells followed by anoikis, a form of apoptosis which occurs after cell detachment, while treatment with SAHA or TRAIL alone did not produce these effects. The effects were more evident in MDA-MB231 cells, which were chosen for ascertaining the mechanism of SAHA/TRAIL action. Our results show…
Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors
2010
Abstract In the last years the application of computational methodologies in the medicinal chemistry fields has found an amazing development. All the efforts were focused on the searching of new leads featuring a close affinity on a specific biological target. Thus, different molecular modeling approaches in simulation of molecular behavior for a specific biological target were employed. In spite of the increasing reliability of computational methodologies, not always the designed lead, once synthesized and screened, are suitable for the chosen biological target. To give another chance to these compounds, this work tries to resume the old concept of Fischer lock-and-key model. The same can …
Guaranteed access mode for downlink traffic over IEEE 802.11 WLANs
2011
IEEE 802.11 networks present an unfairness problem between the downlink and uplink traffic, using the default settings of the Enhanced Distributed Channel Access (EDCA). In order to reduce this unfairness, the Access Point (AP) can adapt the standard parameters, but this is not enough. In this paper, we propose simple and efficient solutions, which are implemented at the AP, thus they are standard compatible and no modifications to the current hardware and protocol stacks are needed. These solutions aim at providing guaranteed access to the downlink traffic when the AP perceives the unfairness problem. Our simulation results show a reduction in the unfairness and an enhancement in network p…
Refugiats i apàtrides. L’asil polític i la protecció internacional a l’Estat espanyol: evolució i impediments
2014
Les politiques de control de fronteres s’han anat consolidant, convertint Europa i l’Estat espanyol en una mena de fortalesa a la qual cada vegada es mes dificil penetrar, i per tant accedir al procediment d’asil. El govern espanyol prioritza la que denominen «lluita contra la migracio irregular» front al compliment dels compromisos que com a Estat, ha signat en materia de Drets Humans, vulnerant aixi el dret al asil i a la Proteccio Internacional recollit, entre d’altres, en la Convencio de Ginebra sobre l’estatut de les persones refugiades.
The RAMON module: architecture framework and performance results
2003
A design study of a Re-configurable Access Module for Mobile Computing Applications is described. After a presentation of its cross-layered architecture, Control Parameters (CPs) of the module are introduced. The set of CPs both describes the functional state of the communication process in relation to the time-varying transport facilities and provides, as input of suitable Algorithms, the control information to re-configure the whole protocol stack for facing modified working conditions. The paper also presents the structure of the simulator realized to demonstrate the feasibility of the design guidelines and to evaluate reconfigurability performances.
The actual management of colorectal liver metastases
2020
Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease. There have been great improvements in the management of CRLM during the last decades. The combination of modern chemotherapeutic and biological systemic treatments with aggressive surgical resection strategies is currently the base for the treatment of patients considered unresectable until few years ago. Furthermore, several new treatments for the local control of CRLM have been developed and are now part of the arsenal of multidisciplinary teams for the treatment of these complex patients. The aim of this review was to s…
Can planning be a research paradigm in architectural design?
1991
Abstract In the present paper we discuss the possible use of ‘planning’ ° to support architectural design. Architectural design is conceived as a process incorporating non-trivial subprocesses consisting of evolutionary sequences of drawings. The ‘planner’ can be viewed as a tool capable of managing the automatic development of formal descriptions of architectural objects, according to goals and constraints which are interactively assigned or removed by the designer. The main features of a ‘planner’ dedicated to architectural design are then put forward. The system has been implemented at the University of Ancona, Italy.
Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library
2019
© Author(s) (or their employer(s)) 2019.