Search results for "Protocol"
showing 10 items of 1808 documents
The role of drug sequence in therapeutic selectivity of the combination of 5-fluorouracil and cis-platin.
1989
The therapeutic efficacy of 5-fluorouracil (FUra) and cis-dichlorodiamine-platinum (cis-DDP) in mice bearing transplantable leukemia and solid tumors was evaluated using different sequences of combination of these agents. The optimal sequence was cis-DDP administered 24 h after FUra. The administration of FUra at its maximally tolerated dose (MTD) followed 24 h later by low doses of cis-DDP yielded less toxicity and higher response rate against L1210 and colon 26 than the administration of these two agents in the opposite sequence or concurrently at the MTD. The sequence of administration of these two agents was not therapeutically important when the antitumor activity was evaluated against…
Cardiotoxicity mechanisms of the combination of BRAF-inhibitors and MEK-inhibitors.
2018
Many new drugs have appeared in last years in the oncological treatment scenario. Each drug carries an important set of adverse events, not less, cardiovascular adverse events. This aspect is even more important considering the increasing use of combination therapies with two drugs, or three drugs as in some ongoing clinical trials. Besides it represents a growing problem for Cardiologists, that face it in every day clinical practice and that will face it probably more and more in the coming years. This work reviews the mechanism of action of BRAF-inhibitors and MEK-inhibitors used together, the pathophysiological mechanisms that lead to cardiovascular toxicity. Particularly, it focuses on …
Quantized Dissensus in Networks of Agents subject to Death and Duplication
2012
Dissensus is a modeling framework for networks of dynamic agents in competition for scarce resources. Originally inspired by biological cells behaviors, it fits also marketing, finance and many other application areas. Competition is often unstable in the sense that strong agents, those having access to large resources, gain more and more resources at the expense of weak agents. Thus, strong agents duplicate when reaching a critical amount of resources, whereas weak agents die when loosing all their resources. To capture all these phenomena we introduce systems with a discrete time gossip and unstable state dynamics interrupted by discrete events affecting the network topology. Invariancy o…
A Novel Energy Model for MANETs based on Graphs with Activation Windows
2005
Energy usage optimization is still an important issue and a critical design factor for mobile ad hoc networks (MANETs). Only recently a few proposals appeared that consider energy-aware optimizations for routing protocols. In this paper we describe an analytical model for MANETs which is based on graphs with activation windows. The activation windows allow to model the on-off status of the network devices. Moreover, we propose an algorithm with pseudo-polynomial complexity, called STP algorithm (STPA), that based on the current position and state of the nodes determines the shortest time path between the source node and the destination node.
Lifespan-Aware Routing for Wireless Sensor Networks
2010
Wireless Sensor Networks (WSNs) have the capability to become the eyes and ears for the future networked society allowing monitoring of any habitat or object's properties remotely and independently of an energy source. Services based on this technology may change the way we monitor and control remote areas and objects. In this paper we propose a different approach to routing data across Wireless Sensor Networks. We argue that a distance-vector protocol using a lifespan-aware metric is a plausible solution to the task of routing information in WSN in a manner that both saves energy of the individual node and manages summarized energy of the system equally and fairly. The concept is designed …
Stability Analysis of Routing Strategies for the Maximum Lifetime Problem in One-Dimensional Ad-Hoc Wireless Networks
2017
In the paper we discuss solutions of the maximum network lifetime problem in one-dimensional, regular ad-hoc wireless networks. For the problem, nodes of the network generate given amount of data and send it possibly via other nodes to the data collector. To extend the network lifetime the data should be transmitted in such a way, that the energy utilized by the most overloaded node is minimized. We assume, that the nodes use the point-to-point data transmission scheme and the cost of transmission of one unit of data is arbitrary superadditive function of a distance between transmitter and receiver. We show that for the one-dimensional network in which the nodes are evenly distributed on th…
A Branch-and-Cut method for the Capacitated Location-Routing Problem
2011
International audience; Recent researches in the design of logistic networks have shown that the overall distribution cost may be excessive if routing decisions are ignored when locating depots. The Location-Routing Problem (LRP) overcomes this drawback by simultaneously tackling location and routing decisions. The aim of this paper is to propose an exact approach based on a Branch-and-Cut algorithm for solving the LRP with capacity constraints on depots and vehicles. The proposed method is based on a zero-one linear model strengthened by new families of valid inequalities. The computational evaluation on three sets of instances (34 instances in total), with 5–10 potential depots and 20–88 …
TBRA: A scalable routing algorithm in highly mobile large scale pure ad hoc wireless mesh networks
2009
In highly mobile pure ad-hoc wireless mesh networks, fast rerouting within low routing discovery delay is a mandatory requirement for routing algorithm to support interactive applications such as VoIP. Also, the communication overhead should be thwarted when networks grow to a large scale. We propose a Tree-Based Routing Algorithm - TBRA to facilitate such two goals. On one hand, TBRA has very low routing discovery delay due to its proactive property. On the other hand, TBRA performs more efficiently than other proactive protocols with respect to low communication overhead, which thanks to its short routing packet length, less numbers and smaller routing table size. Our modeling analysis an…
A flexible and tunable route discovery mechanism for on-demand protocols
2004
Mobile ad-hoc networks are characterized by multihop wireless links and absence of cellular infrastructure. For the last years, routing has been the area under most intensive research. In particular, on-demand routing protocols proposed are extremely attractive due to their low-overhead and efficiency. Currently, wireless ad-hoc networks lack multipath routing protocols. Multipath routing enables increased QoS support, load balancing and enhanced route stability. In this paper we present a new route discovery solution that increases the number of routes found, while reducing the routing overhead when compared to previous proposals. Simulation results show that the additional routing overhea…
Logic-Based Distributed Routing for NoCs
2008
The design of scalable and reliable interconnection networks for multicore chips (NoCs) introduces new design constraints like power consumption, area, and ultra low latencies. Although 2D meshes are usually proposed for NoCs, heterogeneous cores, manufacturing defects, hard failures, and chip virtualization may lead to irregular topologies. In this context, efficient routing becomes a challenge. Although switches can be easily configured to support most routing algorithms and topologies by using routing tables, this solution does not scale in terms of latency and area. We propose a new circuit that removes the need for using routing tables. The new mechanism, referred to as logic-based dis…