Search results for "Prove"

showing 10 items of 588 documents

Novel activities of safe-in-human broad-spectrum antiviral agents

2018

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley feve…

0301 basic medicineviruksetviruses030106 microbiologyAPPROVED DRUGSHEPATITIS-C VIRUSINFLUENZA-A VIRUSBioinformaticsAntiviral AgentsArticle03 medical and health sciencesBroad spectrumVirologyHumansRNA VirusesvirusesCELL-CULTUREPharmacologyZIKA VIRUS-INFECTIONviral diseasesECHOVIRUS 1ta1183DNA VirusesDrug Repositioningta1182MOUSE MODELLIVER-TRANSPLANTATION3. Good healthDrug repositioning030104 developmental biology317 PharmacyVirus DiseasesvirustauditENTRY3111 BiomedicineViral diseaseINHIBITORSAntiviral Research
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Improving Speaker-Independent Lipreading with Domain-Adversarial Training

2017

We present a Lipreading system, i.e. a speech recognition system using only visual features, which uses domain-adversarial training for speaker independence. Domain-adversarial training is integrated into the optimization of a lipreader based on a stack of feedforward and LSTM (Long Short-Term Memory) recurrent neural networks, yielding an end-to-end trainable system which only requires a very small number of frames of untranscribed target data to substantially improve the recognition accuracy on the target speaker. On pairs of different source and target speakers, we achieve a relative accuracy improvement of around 40% with only 15 to 20 seconds of untranscribed target speech data. On mul…

030507 speech-language pathology & audiology03 medical and health sciencesAdversarial systemRecurrent neural networkComputer scienceSpeech recognitionFeed forwardTraining (meteorology)0305 other medical scienceAccuracy improvementIndependence (probability theory)Domain (software engineering)Interspeech 2017
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Systemic support and environmental awareness in a normalised environmental management system consistent with ISO 14001

2021

PurposeThe study aimed to determine the correlations occurring between systemic support and environmental awareness. Additionally, the authors wished to establish which systemic factors (criteria of the ISO 14001) impact those dependencies.Design/methodology/approachQuantitative and qualitative research were carried out (survey findings were analysed against documentation research and self-observation records). The authors used literature review, analysis of system documentation, survey research and self-observation. The research was conducted in the period from April to May 2020. It focused on a chemical company operating within the structure of a large capital group and employing over 1,5…

05 social sciencesEnvironmental awarenessPublic Health Environmental and Occupational Health010501 environmental sciencesManagement Monitoring Policy and Law01 natural sciencesEnvironment management systemenvironment management systemenvironmental awareness0502 economics and businesssystemic supportEnvironmental management systemImprovementBusinessSystemic supportimprovementEnvironmental planning050203 business & management0105 earth and related environmental sciences
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EXTERNAL RECIRCULATION IN PRS TYPE TURBINE: EXPERIMENTAL AND NUMERICAL RESULTS.

2022

Cavitation is a relevant phenomenon for structural safety and noise level in hydraulic turbines, occurring when water pressure falls below the vapor value at a given temperature. In this case bubbles of vapor grow inside the liquid and move along with it. When the pressure returns above the vapor value the bubble collapses, and the pressure can locally achieve very high values, up to 7000 bars (Kumar & Saini, 2010). Moreover, if the bubble was confined also by the solid wall of a blade, the solid particles suspended in the fluid can be transported by the fluid ones and hit the solid wall at very high velocity, generating erosion. Cavitation is also the source of high frequency noise, ve…

3D simulations of a PRS type turbine identify low pressure zones inside the runner.3D Numerical simulations of the modified device confirm the sought after improvement.Experimental measures on a 5 kW prototype also confirm the sought after improvement.External recirculation of a small flux provides the required pressure increment in the target area.Settore ICAR/01 - Idraulica
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Enzimas: qué son y para qué sirven

2007

franco@uv.es

:CIENCIAS DE LA VIDA::Biología celular::Otras [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Biología celular::OtrasEnzimasPropiedadesEnzimas; Propiedades; Funcionamiento; AprovechamientoFuncionamientoAprovechamiento
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La experiencia del Mercado Alternativo Bursátil para Empresas en Expansión (MaB-EE) en España

2015

EXPERIENCIA DEL MERCADO ALTERNATIVO BURSÁTIL PARA EMPRESAS EN EXPANSIÓN (MaB-EE) EN ESPAÑA Mª Ángeles Soler Movilla Universitat de València El marco general de la Tesis lo constituye el segmento del mercado bursátil español especialmente diseñado para la negociación de acciones de empresas de reducida capitalización: el Mercado Alternativo Bursátil para Empresas en Expansión (MaB-EE), perteneciente a Bolsas y Mercados Españoles Sistemas de Negociación SA (BME). Este mercado nace en el año 2009 como un nuevo intento de ofrecer a las pequeñas y medianas empresas españolas la posibilidad de financiarse mediante recursos propios en un mercado bursátil organizado. La creación de este mercado se …

:CIENCIAS ECONÓMICAS::Economía sectorial::Finanzas y seguros [UNESCO]Pymeproveedor de liquidezsalida a Bolsa:CIENCIAS ECONÓMICAS::Organización y dirección de empresas ::Gestión financiera [UNESCO]UNESCO::CIENCIAS ECONÓMICAS::Economía sectorial::Finanzas y segurosUNESCO::CIENCIAS ECONÓMICAS::Organización y dirección de empresas ::Gestión financieraInfravaloraciónMercado alternativo bursátilliquidez acciones
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Protection of the surviving spouse in French law

2021

While French inheritance law has recently sought to give everyone more freedom to anticipate the transmission of their estate, it still guarantees to the children a reserved portion in his estate. This guarantees the deceased?s children a minimum share in his/her estate. However, the mechanisms protecting this reserve are subject to legal adjustments when spouses wish to organize the protection of the couple?s survivor, either by submitting to a conventional matrimonial regime or by giving themselves gifts that improve the legal succession of the spouse. This ensures a balance between the protection of the spouse and that of the compulsory heirs. Not seeming to be satisfied, several famous …

:CIENCIAS JURÍDICAS [UNESCO]reserve2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113546 Protection of the surviving spouse in French law BerryRégimen matrimonial convencionalUNESCO::CIENCIAS JURÍDICASElsa While French inheritance law has recently sought to give everyone more freedom to anticipate the transmission of their estateeither by submitting to a conventional matrimonial regime or by giving themselves gifts that improve the legal succession of the spouse. This ensures a balance between the protection of the spouse and that of the compulsory heirs. Not seeming to be satisfiedseveral famous French people living abroad have recently sought to escape French law in order to be able to give their surviving spouses an advantage beyond these limitsthe mechanisms protecting this reserve are subject to legal adjustments when spouses wish to organize the protection of the couple?s survivorobsequio 24 33the protection of the spouse may be both a reason to submit to French law as well as a motivation to try to escape it. Conventional matrimonial regimesurviving spousereservait still guarantees to the children a reserved portion in his estate. This guarantees the deceased?s children a minimum share in his/her estate. Howevergiftcónyuge supérstiteat the expense of children of first French marriage. Thus
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La nueva oportunidad de la hipoteca inversa

2021

The reverse mortgage is a credit or loan guaranteed by a mortgage that falls on the applicant?s habitual residence, granted at once, or through periodic benefits, to a person who must be over a certain age or prove a degree of disability or dependency, and is not due until the time of death. In view of the doubts that the future of the public pension is raising and the concentration of savings in Spanish property, the reverse mortgage is once again being put on the table as a viable alternative to complement a public pension with little revaluation, in view of the increase in life expectancy and expenses after retirement.

:CIENCIAS JURÍDICAS [UNESCO]retirement 160 207viviendaAna Suyapa The reverse mortgage is a credit or loan guaranteed by a mortgage that falls on the applicant?s habitual residenceguaranteejubilaciónto a person who must be over a certain age or prove a degree of disability or dependencyhipoteca inversaor through periodic benefitsthe reverse mortgage is once again being put on the table as a viable alternative to complement a public pension with little revaluationUNESCO::CIENCIAS JURÍDICASreverse mortgagegarantíagranted at onceand is not due until the time of death. In view of the doubts that the future of the public pension is raising and the concentration of savings in Spanish propertyin view of the increase in life expectancy and expenses after retirement. Hipoteca2070-8157 22082 Revista Boliviana de Derecho 565487 2021 31 7730056 La nueva oportunidad de la hipoteca inversa Fernández-Sancho TahocespréstamoloanhousingMortgage
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Primeras consideraciones a la Ley Orga?nica 3/2021, de 24 de marzo, de regulación de la eutanasia. el reconocimiento de un nuevo derecho

2021

The aim of this paper is to carry out a brief study of the recent Organic Law 3/2021, of March 24, on the regulation of euthanasia (BOE. March 25, 2021) approved in Spain, from a constitutional perspective, highlighting its main aspects. The matter under study is not exempt from controversy because it covers legal, medical and ethical considerations of great complexity.

:CIENCIAS JURÍDICAS [UNESCO]suicidio asistidolifeassisted suicidederechosdespenalizaciónCuthanasiaof March 24de 24 de marzode regulación de la eutanasia. el reconocimiento de un nuevo derecho Agut Garcíahighlighting its main aspects. The matter under study is not exempt from controversy because it covers legalvidaon the regulation of euthanasia (BOE. March 25UNESCO::CIENCIAS JURÍDICASdeath2021) approved in Spainrightsmuertedecriminalization 980 995María Teresa The aim of this paper is to carry out a brief study of the recent Organic Law 3/20212070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055245 Primeras consideraciones a la Ley Orga?nica 3/2021from a constitutional perspectivemedical and ethical considerations of great complexity. Eutanasia
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IMPROVE-IT: what have we learned?

2016

Purpose of review: Recent studies and dyslipidemia treatment guidelines indicate that combination lipid-lowering therapy is frequently needed and its use has increased in recent years. Ezetimibe and simvastatin as a fixed dose is an efficacious treatment choice based on positive results of the recent IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT). In this review, we discuss recent controversies surrounding ezetimibe and provide clinical perspective on the results of the IMPROVE-IT study. Recent findings: IMPROVE-IT is the first trial that demonstrates a significant clinical benefit of a nonstatin hypolipidemic agent (ezetimibe) used in combination with sta…

Acute coronary syndromeSimvastatinHypercholesterolemia030204 cardiovascular system & hematologyPharmacologyFixed dose03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePharmacotherapyEzetimibeMedicineHumansLow-density lipoprotein cholesterol030212 general & internal medicineAcute Coronary SyndromeIMPROVE-IT trialbusiness.industryCholesterolAnticholesteremic AgentsAnticholesteremic Agentsnutritional and metabolic diseasesCholesterol LDLmedicine.diseaseCardiovascular riskEzetimibeTreatment OutcomechemistrySimvastatinAzetidinesDrug Therapy CombinationHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessCardiology and Cardiovascular MedicineDyslipidemiamedicine.drugCurrent opinion in cardiology
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