Search results for "Prove"

Optimizing patient referral and center capacity in the management of chronic hepatitis C: Lessons from the Italian experience

2019

Abstract Aims In 2017 the Italian Drug Agency (Agenzia Italiana del Farmaco, AIFA) revised the criteria for access to therapy for patients with chronic hepatitis C as part of a three-year plan to eradicate HCV. We conducted a Delphi study to determine strategies to identify and treat patients with HCV and to develop through a shared pathway, a model to manage patient referral and optimize prescription center capacity with the overall aim of increasing access to therapy. Methods The process took place in two phases – Phase I (January 2017), before the criteria for treatment of HCV were revised and Phase II (May 2017) when AIFA developed a framework for the eradication of HCV infection in Ita…

Differences in ground reaction forces and shock impacts between nordic walking and walking.

2014

The regular practice of Nordic walking (NW) has increased in recent years, in part thanks to the health benefits described by the scientific literature. However, there is no consensus on the effects of shock-impact absorption during its practice. Purpose: The aim of this study was to compare the levels of impact and ground reaction forces (GRF) between NW and walking (W). Method: Twenty physically active and experienced participants were assessed using a dynamometric platform and accelerometry analysis. Results: The results show statistically significantly higher levels of acceleration in the tibia (12%) and head (21%) during NW compared with W. Equally, GRF were significantly higher (27%) …

Lifetime, 5-year and past-year prevalence of homelessness in Europe: a cross-national survey in eight European nations

2019

ObjectivesTo examine the lifetime, 5-year and past-year prevalence of homelessness among European citizens in eight European nations.DesignA nationally representative telephone survey using trained bilingual interviewers and computer-assisted telephone interview software.SettingThe study was conducted in France, Ireland, Italy, the Netherlands, Poland, Portugal, Spain and Sweden.ParticipantsEuropean adult citizens, selected from opt-in panels from March to December 2017. Total desired sample size was 5600, with 700 per country. Expected response rates of approximately 30% led to initial sample sizes of 2500 per country.Main outcome measuresHistory of homelessness was assessed for lifetime, …

European perspective on the 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroi…

2018

The American Thyroid Association (ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. European experts frequently have different perspectives, given epidemiological, technological/methodological, practice organization, and medicolegal differences between the respective regions.Divergent viewpoints were the focus of an invited symposium organized by the European Association of Nuclear Medicine involving 17 European thyroidologists, four ATA Guidelines Taskforce members, and…

Prospective Parallel Randomized, Double-Blind, Double-Dummy Controlled Clinical Trial Comparing Clomiphene Citrate and Metformin as the First-Line Tr…

2005

Abstract Context: Although metformin has been shown to be effective in the treatment of anovulation in women with polycystic ovary syndrome (PCOS), clomiphene citrate (CC) is still considered to be the first-line drug to induce ovulation in these patients. Objective: The goal of this study was to compare the effectiveness of metformin and CC administration as a first-line treatment in anovulatory women with PCOS. Design: We describe a prospective parallel randomized, double-blind, double-dummy controlled clinical trial. Setting: The study was conducted at the University “Magna Graecia” of Catanzaro, Catanzaro, Italy. Patients: One hundred nonobese primary infertile anovulatory women with PC…

Evaluation of the MGDRx eyebag treatment in young and older subjects with dry eye symptoms

2021

Summary Objectives This study aims to evaluate the relationship between application of the MGDRx thermal eyebag and dry eye signs and symptoms in young and older subjects and to compare the results between the two groups. Methods Thirty young, healthily volunteers between 18 and 31 years of age (23.95 ± 3.94 years) and thirty older subjects between 61 and 90 years of age (77.97 ± 8.11 years) participated in this study. Ocular surface parameters were assessed using the Oculus Keratograph 5 M, following the guidelines of the Tear Film and Ocular Surface Dry Eye Workshop II Diagnostic Methodology report. Only subjects with a positive score on at least one questionnaire and an initial Non-Invas…

2016

In studying holistic face processing across the life-span there are only few attempts to separate face-specific from general aging effects. Here we used the complete design of the composite paradigm (Cheung et al., 2008) with faces and novel non-face control objects (watches) to investigate composite effects in young (18-32 years) and older adults (63-78 years). We included cueing conditions to alert using a narrow or a wide attentional focus when comparing the composite objects, and used brief and relaxed exposure durations for stimulus presentation. Young adults showed large composite effects for faces, but none for watches. In contrast, older adults showed strong composite effects for fa…

First record of the enigmatic coleoid genus Longibelus from Sakhalin (Far East Russia): a contribution to our understanding of Cretaceous coleoid hab…

2021

AbstractA newly collected specimen of the enigmatic coleoid genus Longibelus is recorded from lower Turonian strata along the River Shadrinka in Sakhalin (Russian Far East). To date, this is the first record of Late Cretaceous coleoid cephalopods from the island and, in fact, from the entire Pacific coast of the Russian Federation. Lithological characteristics, coupled with published geochemical analyses (δ13C and Corg content), suggest the habitat of this coleoid taxon to have been the middle to outer (i.e. distal) shelf. Its provenance from the stratigraphical level that is known as the Scaphites Event, characterised by a mass occurrence of Scaphites and Yesoites, may be indicative of occ…

A recipe for the use of rutile in sedimentary provenance analysis

2012

Abstract Rutile has received considerable attention in the last decade as a valuable petrogenetic indicator mineral. Based on both new and previously published data, we carve out advantages and pitfalls regarding TiO 2 -minerals in sedimentary provenance analysis. This results in a recipe for the use of rutile in provenance studies. The main points are: Rutile geochemistry from different grain size fractions does not differ systematically, and hence rutiles should be extracted from the fraction containing the most rutile grains (usually 63–200 μm). Similarly, different magnetic susceptibility of rutile does not systematically imply different trace element composition. Before interpretation …

Relationship between anthropometric parameters, physiological responses, routes and competition results in formula windsurfing

2012

Formula windsurfing is faster than the Olympic version, due to anumber of unique differences. This study was designed to identify the importance of anthropometric and cardiac factors on the final result of the European Formula Windsurf Championships (2007). We selected 45 competitors (30 amateurs and 15 professionals) of 30±9.77 years of age, a height of 182.6±0.06 cm, a weight of 81.67±7.35 kg and a BMIof 24.7±2.1 kg. They were divided into three groups (PG: 15; TG: 45and GPSG: 12). We followed the recommendations of Carter and Marfell-Jones for the anthropometric measurements. The route, speed, distance and heart rate were recorded using an FRWD W600 GPS (Global Positioning System) unit. …