Search results for "Pulmonary Emphysema"
showing 9 items of 19 documents
Functional Evaluation of Emphysema Using Diffusion-Weighted 3Helium-Magnetic Resonance Imaging, High-Resolution Computed Tomography, and Lung Functio…
2004
Purpose: To assess the emphysematous enlargement of distal air-spaces and concomitant large and small airway disease using diffusion-weighted 3 Helium-magnetic resonance imaging (MRI), high-resolution computed tomography (HRCT), and lung function tests (LFT). Methods: Seven patients were examined after single lung transplantation (LTx) and 1 before double LTx for various forms of emphysema. Five patients after double LTx served as controls. Patients were assessed by 3 Helium-MRI (apparent diffusion coefficient [ADC]), HRCT (mean lung density [MLD], emphysema index [El]), and LFT. Results: Transplanted lungs: mean ADC = 0.17 cm 2 /s, MLD = -848 H, El = 22%. Emphysematous lungs: mean ADC = 0.…
Vollautomatische Detektion und Quantifizierung des Lungenemphysems in Dünnschicht-MD-CT des Thorax durch eine neue, speziell entwickelte Software
2004
Purpose: Introduction of a novel software tool (YACTA - yet another CT analyzer) for detection and quantification of pulmonary emphysema in thin-slice chest MDCT data sets. Materials and Methods: Consisting of grey-level threshold-based algorithms (e. g., region-growing), expert rules and morphological image postprocessing YACTA segments the tracheobronchial tree prior to the detection and quantification of pulmonary emphysema. In addition to general parameters, such as the mean lung density (MLD) and the emphysema index (EI - also described as pixel index PI), the previously described bullae index (BI) is transformed into a three-dimensional parameter for a morphological description of emp…
Untersuchung des Ventilations-Durchblutungs-Verh�ltnisses in der funktionell inhomogenen Lunge mittels des ?inspiratorischen Sauerstoffsprunges?
1964
Es wird ein neues Verfahren zur Analyse der Verteilung des Ventilations-Durchblutungs-Verhaltnisses in der funktionell inhomogenen Lunge beschrieben. Die hiermit an gesunden Versuchspersonen und Patienten mit ausgepragtem obstruktiven Lungenemphysem durchgefuhrte Untersuchung fuhrt zu folgenden Ergebnissen: 1. Das Ventilations-Durchblutungs-Verhaltnis weist beim Gesunden eine charakteristische Verteilung im Bereich von etwa 0,5–2,0 auf. Dadurch entsteht eine verteilungsbedingte alveolar-arterielle Druckdifferenz, die fur Sauerstoff 1–8 Torr, fur Kohlendioxyd 0,5–3 Torr betragt. Die Inhomogenitat der Durchblutungsgrose ist in diesem Fall von untergeordneter Bedeutung. 2. Bei Emphysematikern …
Characterization of the interstitial lung and peripheral blood T cell receptor repertoire in cigarette smokers.
2005
T lymphocytes modulate the pulmonary inflammatory response. The aim of this study was to evaluate the clonality within the interstitial lung and peripheral blood T cell receptor (TCR) repertoire in smokers. Interstitial T lymphocytes were isolated from surplus tissue of 16 patients (63 +/- 9 [+/- SD] yr old, 11 male) undergoing surgery due to lung cancer (n = 15) or emphysema. TCR clonality was assessed by PCR amplification followed by spectratyping. Nearly all TCR of interstitial lung lymphocytes showed oligoclonal bands (CD4(+) subset 13/16 patients, 81%; CD8(+) 100%) indicating a specific differentiation. Peripheral blood T lymphocytes (PBL) TCR (especially CD4(+)) had less oligoclonal b…
German Thoracic Research Scholarship 1996: lung volume reduction for endstage pulmonary emphysema at the Washington University of St. Louis.
1998
The Thoracic Research Scholarship 1996 of the German Society for Thoracic and Cardiovascular Surgery enabled me to visit Barnes Hospital at the Washington University of St. Louis, USA, from May to July 1996. At that center Prof. J. D. Cooper has established lung-volume reduction surgery as a successful surgical treatment for patients with endstage pulmonary emphysema. The operation is performed using left-sided double-lumen intubation. After opening of the chest and pleura and starting single-lung ventilation the less diseased parts of the second lung collapse due to absorption atelectasis whereas the more diseased portion of the lung stays hyperinflated. Linear staplers buttressed with bov…
Global burden of chronic respiratory diseases and risk factors, 1990-2019: an update from the Global Burden of Disease Study 2019
2023
Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019.Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD)…
The treatments of pursiness in the ancient time
2009
The pursiness is a very old disease known since antiquity whose name comes from the fact that affected horse have difficulties to expirate air and produce a movement of forced expiration to expel air. This symptom is now mainly related to pulmonary emphysema. Treatments remained generally the same from antiquity to the nineteenth century. They used mainly bleeding and therapeutic mixtures supposed to work on the lung. The revolution was to come in the nineteenth century with the use of arsenic.
Quantification and Characterization of Pulmonary Emphysema in Multislice-CT
2003
The new technology of the Multislice-CT provides volume data sets with approximately isotropic resolution, which permits a non invasive measurement of diffuse lung diseases like emphysema in the 3D space. The aim of our project is the development of a full automatic 3D CAD (Computer Aided Diagnosis) software tool for detection, quantification and characterization of emphysema in a thoracic CT data set. It should supply independently an analysis of an image data set to support the physician in clinical daily routine. In this paper we describe the developed 3D algorithms for the segmentation of the tracheo-bronchial tree, the lungs and the emphysema regions. We present different emphysema des…
Repräsentiert der HRCT-Emphysemindex die gesamte Lunge?
2005
Purpose: Comparison of emphysema index derived of thin section MD-CT of the entire lung volume and HRCT, simulated by calculation of every twentieth image of the whole data-set. Materials and Methods: Pulmonary emphysema was quantified by semiautomatic, segmentation of lung borders and assessment of lung volume and emphysema volume within these borders. The emphysema index (pixel index) was calculated. Statistical analysis was done by the sign-test and Bland-Altman-analysis. Results: Median lung volume, emphysema volume and emphysema index are significantly higher in simulated HRCT. Median lung volume (emphysema volume) calculated by HRCT is 5118 ml (407 ml) and 5040 ml (367 ml) calculated …