Search results for "Puma"
showing 10 items of 70 documents
Eiropas Komisijas ierosināto pārkāpuma procedūru pret Eiropas Savienības dalībvalstīm analīze
2019
Eiropas Komisijas ierosinātās pārkāpuma procedūras pret Eiropas Savienības dalībvalstīm ir viens no svarīgākajiem tiesību instrumentiem, ar kuru tiek nodrošināts Eiropas Savienības tiesību pārākums un panākta tiesību harmonizācija starp Eiropas Savienības dalībvalstīm. Tomēr, ņemot vērā laika gaitā notikušās izmaiņas pārkāpuma procedūru tiesiskajā mehānismā, bieži vien centieni veicināt to efektivitāti panāk pretējo efektu. Attiecīgi darbā autore apskata pārkāpuma procedūru tiesiskā mehānisma vēsturi, attīstību, veidus un gaitu, kā arī analizēs aktuālākos problēmjautājumus, kas sevī ietver Eiropas Komisijas un Eiropas Savienības Tiesas neviennozīmīgo praksi. Darbā tiek analizēta arī Līguma …
Asymptotic and bootstrap tests for subspace dimension
2022
Most linear dimension reduction methods proposed in the literature can be formulated using an appropriate pair of scatter matrices, see e.g. Ye and Weiss (2003), Tyler et al. (2009), Bura and Yang (2011), Liski et al. (2014) and Luo and Li (2016). The eigen-decomposition of one scatter matrix with respect to another is then often used to determine the dimension of the signal subspace and to separate signal and noise parts of the data. Three popular dimension reduction methods, namely principal component analysis (PCA), fourth order blind identification (FOBI) and sliced inverse regression (SIR) are considered in detail and the first two moments of subsets of the eigenvalues are used to test…
Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis
2018
International audience; The p53 protein is a key tumor suppressor in mammals. In response to various forms of genotoxic stress p53 stimulates expression of genes whose products induce cell cycle arrest and/or apoptosis. An E3-ubiquitin ligase, Mdm2 (mouse-double-minute 2) and its human ortholog Hdm2, physically interact with the amino-terminus of p53 to mediate its ubiquitin-mediated degradation via the proteasome. Thus, pharmacological inhibition of the p53-Mdm2 interaction leads to overall stabilization of p53 and stimulation of its anti-tumorigenic activity. In this study we characterize the biological effects of a novel class of non-genotoxic isatin Schiff and Mannich base derivatives (…
HTML5 monialustaisessa pelikehityksessä : kaksiulotteiset minipelit Phaser-pelimoottorilla
2015
Mobiililaitteiden yleistyessä videopelien pelaamiseen on tarve pelien helpommalle kehitykselle ja levitykselle kasvanut. HTML5 on avoin web-standardi, joka mahdollistaa monialustaisen multimediasisällön näyttämisen suoraan Internet-selaimissa. HTML5:n avulla voikin olla mahdollista luoda pelejä, jotka eivät kärsi natiiviohjelmien tavoin yhteensopivuus- tai asennusongelmista. On kuitenkin oletettavaa, ettei HTML5 ja siihen sidoksissa olevat tekniikat tai sitä tukevat Internet-selaimet ole vielä täysin valmiita kaikkiin web-teknologian asettamiin haasteisiin, mutta sitä voitaneen kaikesta huolimatta jo käyttää täysin pelattavien ajanvietepelien toteuttamiseen. Tämä tutkielma tutkii monialusta…
Spatiaalisen ikkunoinnin ja sokean signaalinerottelun menetelmien hyödyntäminen MEG-aineiston analysoinnissa
2018
Sokean signaalinerottelun menetelmät ovat käyttökelpoisia magnetoenkefalografilla mitattujen aivomagneettikäyrien analysoinnissa. Sokean signaalinerottelun menetelmien avulla voidaan selvittää, mistä aivoaktivaatio on peräisin ja millaisiin toimintoihin aktivaatio voidaan yhdistää. MEG-aineiston ajallinen tarkkuus on hyvä, joten lyhytkin mittausaika tuottaa hyvin suuren aineiston. Suuren aineiston tuottamat laskennalliset ongelmat voidaan kiertää ikkunoimalla MEG-aineisto aika- tai tilasuunnassa. Aineiston ikkunointia on sovellettu aiemmissa tutkimuksissa toiminnallisen magneettikuvauksen aineistoon, jolloin ikkunointi on tehty aikasuunnassa. Tässä tutkielmassa ikkunointia sovellettiin MEG-…
Radial and peripheral clines in northern polymorphic populations of Philaenus spumarius
2009
Geographic variability in the colour polymorphism of Philaenus spumarius (Homoptera) was investigated in the northern parts of Finland, Norway and Sweden. The investigation was directed mainly at peripheral populations south of the Baltic—Arctic divide. The colour phenotypes were found to differ in their “north tolerance”. The phenotypes typ (pt/pt) and lat (pt/pt) were the most, and the phenotype tri (pt/pT) the least tolerant to marginal conditions. Differences in “north tolerance” between the phenotypes cause radial clines to be present in allele frequencies. The radial clines may be caused by the combined effect of several different factors. These include shortness of the thermal growth…
The founder principle, founder selection, and evolutionary divergence and convergence in natural populations of Philaenus
2009
Parts of the archipelago of the Baltic Sea are rising above the water level at a steady, slow rate. Plant species appear on the emerging islands in a definite order, and an early stage and a late stage can be distinguished in the development of meadows on the islands. In 1969–1973 four populations of Philaenus spumarius living in meadows at the early stage had widely different frequencies of the alleles determining colour polymorphism. In the same years three Philaenus populations living on islands with meadows at the late stage had closely similar allele frequencies. The differences between the Philaenus populations in the early stage meadows are ascribed partly to the founder principle an…
Puma (Puma concolor) epididymal sperm morphometry
2016
The Andean puma (Puma concolor) has not been widely studied, particularly in reference to its semen characteristics. The aim of the present study was to define the morphometry of puma sperm heads and classify their subpopulations by cluster analysis. Samples were recovered postmortem from two epididymides from one animal and prepared for morphological observation after staining with the Hemacolor kit. Morphometric data were obtained from 581 spermatozoa using a CASA-Morph system, rendering 13 morphometric parameters. The principal component (PC) analysis was performed followed by cluster analysis for the establishment of subpopulations. Two PC components were obtained, the first related to …
The squared symmetric FastICA estimator
2017
In this paper we study the theoretical properties of the deflation-based FastICA method, the original symmetric FastICA method, and a modified symmetric FastICA method, here called the squared symmetric FastICA. This modification is obtained by replacing the absolute values in the FastICA objective function by their squares. In the deflation-based case this replacement has no effect on the estimate since the maximization problem stays the same. However, in the symmetric case we obtain a different estimate which has been mentioned in the literature, but its theoretical properties have not been studied at all. In the paper we review the classic deflation-based and symmetric FastICA approaches…
Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer?
2014
Abstract: Immunotherapy has been studied for many years in lung cancer without significant results, making the majority of oncologists quite skeptical about its possible application for non-small cell lung cancer treatment. However, the recent knowledge about immune escape and subsequent cancer immunoediting has yielded the development of new strategies of cancer immunotherapy, heralding a new era of lung cancer treatment. Cancer vaccines, including both whole-cell and peptide vaccines have been tested both in early and advanced stages of non-small cell lung cancer. New immunomodulatory agents, including anti-CTLA4, anti-PD1/PDL1 monoclonal antibodies, have been investigated as monotherapy …