Search results for "QS"

Le séquençage massif pour caractériser la diversité microbienne des sols, standardisation et applications au sein de la plateforme GenoSol

2014

EA SPE GenoSol EcolDur; National audience; Les microorganismes (bactéries, archées et champignons) sont les organismes les plus abondants et les plus diversifiés de la matrice sol. Ils représentent un réservoir encore largement méconnu et presque infini de ressources génétiques, fortement impliqué dans le fonctionnement biologique du sol et plus largement dans la plupart des services écosystémiques fournis par ce sol. Malgré ce rôle central dans le fonctionnement des écosystèmes, nos connaissances sur la diversité génétique, taxonomique et fonctionnelle de ces microorganismes restent limitées à ce jour. Ceci s’explique essentiellement par des difficultés techniques pour accéder à ces organi…

Microbial Biogeography at the scale of France by the use of molecular tools applied to the French soil quality monitoring network (RMQS)

2008

Microbial-biogeography at the scale of France by the use of molecular tools applied to the French soil quality monitoring network (RMQS)

2009

International audience

ECOMIC-RMQS: Inventaire et cartographie de la diversité microbienne des sols à l'échelle du territoire national

2008

Application de l'approche QSAR/QSPR à la perception des arômes

2009

National audience

Study of relationships between the structure of aroma compounds and their retention-release between vapour phase and dairy gels

2010

An integrated approach physicochemistry and structures activity relationships has been carried out to study the aroma compounds retention-release phenomenon in a fat free dairy gel added with pectin. This study aimed to identify the molecular properties that govern this phenomenon assuming that modifying the structure leads automatically to a change in the retention-release of aroma compounds. For this purpose, we have determined the partition coefficients of 28 aroma compounds in water, in pectin gels and in dairy gels supplemented or not supplemented with pectin, at equilibrium conditions using the PRV method (Phase Ratio Variation). Then, we have performed a structure-retention relations…

Quieter and more civilised but not more accountable

2020

International audience; Pmqs as a tool to hold the government to account has long been dismissed as a counter-productive “Punch and Judy show”. Since the Covid-19 restrictions came into effect in the House of Commons, those sessions have become less crowded and notably quieter. This unprecedented state of affairs have considerably undermined the “tribal effect” typical of parliamentary groups during Pmqs. Additionally the video conferencing technology requires more attention and calm in the house. Consequently, the confrontational quality of the debates has turned into an uncharacterically pacified moment. The number of interruptions and face attacking acts (insults) have been reduced to no…

How Molecular Topology Can Help in Amyotrophic Lateral Sclerosis (ALS) Drug Development: A Revolutionary Paradigm for a Merciless Disease

2022

r Abstract: Even if amyotrophic lateral sclerosis is still considered an orphan disease to date, its prevalence among the population is growing fast. Despite the efforts made by researchers and pharmaceutical companies, the cryptic information related to the biological and physiological onset mechanisms, as well as the complexity in identifying specific pharmacological targets, make it almost impossible to find effective treatments. Furthermore, because of complex ethical and economic aspects, it is usually hard to find all the necessary resources when searching for drugs for new orphan diseases. In this context, computational methods, based either on receptors or ligands, share the capabil…

Diversité des communautés microbiennes telluriques à l'échelle du territoire national

2009

Communication orale - résumé Session 5 : sols, biodiversité, écologie fontionnelleCommunication orale - résumé Session 5 : sols, biodiversité, écologie fontionnelle; absent

Novel anti-obesity drugs and plasma lipids

2014

Obesity is a health problem of global, epidemic proportions and a major risk factor for chronic diseases resulting in accelerated morbidity and mortality. Dyslipidemia with a predominance of small dense LDL, impaired functionality of HDL particles, and increased serum levels of remnant particles due to impaired clearance of triglyceriderich lipoproteins significantly heightens cardiovascular events in obese subjects. Pharmacotherapy in combination with lifestyle modification is the primary approach to reduce obesity-related cardiovascular risk. Although there are several potential anti-obesity drugs, orlistat is the only agent that remains available in the market. Lorcaserin and Qsymia ® , …