Search results for "QT"
showing 10 items of 113 documents
Activation of the Cyano Group at Imidazole via Copper Stimulated Alcoholysis
2019
Reactions of 4,5-dicyano-1-methylimidazole with CuX2 (X = Cl, Br) in alcohol solvents (ethanol and methanol) resulted in the formation of Cu(II) carboximidate complexes [CuCl2(5- cyano-4-C(OEt)N-1-methylimidazole)(EtOH)] (1), [Cu2(µ
Combined use of liquid chromatography triple quadrupole mass spectrometry and liquid chromatography quadrupole time-of-flight mass spectrometry in sy…
2012
As a suitable way for routine screening of pesticides and control of other organic contaminants in water, the combination of liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS) and liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) has been applied to the analysis of 63 surface and waste water samples after conventional solid-phase extraction (SPE). The extracts were screened for 43 pesticides or degradation products by LC-QqQ-MS/MS achieving limits of detection (LOD) ranged from 0.04 to 2 ng L(-1). Of the 43 selected pesticides, 33 were detected in water samples. The ESI-QTOF MS instrument was run using two simultaneous acquisi…
Profiling of compounds and degradation products from the postharvest treatment of pears and apples by ultra-high pressure liquid chromatography quadr…
2010
This study deals with a simple strategy to pinpoint potential unknown compounds in full scan mass spectrometry (MS) experiments. Forty samples of apples and pears intended for human consumption were analyzed by ultra-high performance liquid chromatography quadrupole-time-of-flight (UPLC–QqTOF-MS), after extraction of the possible contaminants by rinsing the peel of the fruit with ethyl acetate. The peaks were visually recognized in the total ion chromatogram (TIC). Two major types of postharvest treatments were detected in this set of samples: imazalil (IMZ)/ethoxyquin (EQ) and thiabendazole (TBZ)/diphenylamine (DPA). The present work also describes the metabolites formed by degradation of …
Anticancer therapy-induced vascular toxicity: VEGF inhibition and beyond
2017
Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases.…
Use of translational genomics to identify genes important for legume seed development
2015
BAP Pôle GEAPSI; International audience; We have exploited the extensive synteny between the model legume Medicago truncatula and the cultivated garden pea, Pisumsativum, to identify loci controlling seed filling and seedcomposition in the crop species. QTLs for these traits are mapped by analyzing variation with in collections of recombinant inbred lines. Candidate genes with in the QTL intervals are identified by reference to the M.truncatula genomic sequence. This approach was used to uncover an endosperm subtilase that is associated with syntenic seed weight QTLs in Medicago and pea, and we discuss the possible role played by this enzyme in contributing to final seed weight.
Recherche de déterminants génétiques et moléculaires impliqués dans l’architecture racinaire et nodulaire des légumineuses et contribuant à une améli…
2016
La culture de Légumineuses présente le double intérêt de permettre une production de graines à haute valeur nutritionnelle sans nécessité d’un apport d’engrais azoté. La nutrition azotée des légumineuses dépend en effet majoritairement de la fixation symbiotique de l’azote atmosphérique réalisée par des bactéries du sol, les rhizobia, au sein des nodosités, et dans une moindre mesure, de l’assimilation de l’azote minéral du sol par les racines. Une meilleure compréhension a été acquise, par ce travail de thèse, sur le contrôle génétique de la mise en place des racines et des nodosités et sur leur impact sur la nutrition azotée. Une grande variabilité génétique pour ces caractères a été mise…
Psychometric properties of the «Spanish Burnout Inventory» (SBI) in a sample of Italian health professionals: a gender perspective
2017
El objetivo de este estudio fue analizar las propiedades psicométricas del Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo (CESQT) en una muestra de profesionales de la salud italianos. La muestra estuvo formada por 695 participantes (453 profesionales de enfermería y 242 médicos). Según el género se identificaron 451 mujeres (64.9%) y 244 hombres (35.1%). El CESQT está formado por 20 ítems que se distribuyen en cuatro dimensiones: Ilusión por el trabajo (5 ítems), Desgaste psíquico (4 ítems), Indolencia (6 ítems), y Culpa (5 ítems). La estructura factorial se analizó mediante análisis factorial confirmatorio. Todos los ítems presentaron valores adecuados para los pa…
El síndrome de quemarse por el trabajo (burnout) en profesionales de residencias de personas con discapacidad y su relación con las actitudes hacia l…
2018
Introducción. El Síndrome de Quemarse por el Trabajo (SQT) o Burnout es un síndrome psicológico (no una enfermedad mental) que se produce a causa de una respuesta prolongada al estrés en el lugar de trabajo (Maslach, 2003), un proceso que surge como respuesta al estrés laboral crónico y, por tanto, es un fenómeno que está vinculado a la aparición de riesgos psicosociales en el trabajo, un fenómeno subjetivo y de carácter negativo en el que entran en juego cogniciones, emociones y actitudes (negativas) hacia los otros en el trabajo, principalmente los usuarios o clientes (Gil-Monte, 2005). Aunque el SQT puede darse en diferentes colectivos profesionales, el mayor número de casos y las más im…
Contaminants of emerging concern in the environment. Turia River as study case
2018
Tesis llevada a cabo para conseguir el grado de Doctor por la Universidad de Valencia.--2018-04-05
Persistence of oxidation state III of gold in thione coordination
2017
Ligands N,N'-tetramethylthiourea and 2-mercapto-1-methyl-imidazole form stable Au(III) complexes [AuCl3(N,N'-tetramethylthiourea)] (1) and [AuCl3(2-mercapto-1-methyl-imidazole)] (2) instead of reducing the Au(III) metal center into Au(I), which would be typical for the attachment of sulfur donors. Compounds 1 and 2 were characterized by spectroscopic methods and by X-ray crystallography. The spectroscopic details were explained by simulation of the UV-Vis spectra via the TD-DFT method. Additionally, computational DFT studies were performed in order to find the reason for the unusual oxidation state in the crystalline materials. The preference for Au(III) can be explained via various weak in…