Search results for "QUALITY-CONTROL"
showing 3 items of 3 documents
Quality-control procedure for dry-process rubberised asphalt mastics
2019
Crumb Rubber (CR) can be incorporated into asphalt mixes via the dry process by directly adding CR into the mixer together with other asphalt mixture’s components, or with the wet process where the CR is used as a bitumen modifier. While the wet process allows an accurate monitoring of the interaction between CR and bitumen, the lack of control represents a main issue in the dry process. In fact, in the latter the CR particles keep swelling during hauling and possibly also after paving operations, often causing workability issues and premature failures. This study wants to provide a methodology that could help quality control procedures of bitumen/filler/rubber systems during mixing, haulin…
Exome-wide somatic mutation characterization of small bowel adenocarcinoma
2018
Small bowel adenocarcinoma (SBA) is an aggressive disease with limited treatment options. Despite previous studies, its molecular genetic background has remained somewhat elusive. To comprehensively characterize the mutational landscape of this tumor type, and to identify possible targets of treatment, we conducted the first large exome sequencing study on a population-based set of SBA samples from all three small bowel segments. Archival tissue from 106 primary tumors with appropriate clinical information were available for exome sequencing from a patient series consisting of a majority of confirmed SBA cases diagnosed in Finland between the years 2003–2011. Paired-end exome sequencing was…
Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemother…
2011
Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y Tratamiento de las Hemopatias Malignas (PETHEMA) and Hemato-Oncologie voor Volwassenen Nederland (HOVON) groups between 1996 and 2005. Results FLT3-internal tandem duplication and FLT3-D835 mutation status was available for 306 (41%) and 213 (29%) patients, respectively. Sixty-eight (22%) and 20 (9%) pa…