Search results for "Quantitative"

showing 10 items of 2409 documents

Density functional theory fragment descriptors to quantify the reactivity of a molecular family: Application to amino acids

2007

By using the exact density functional theory, one demonstrates that the value of the local electronic softness of a molecular fragment is directly related to the polarization charge (Coulomb hole) induced by a test electron removed (or added) from (at) the fragment. Our finding generalizes to a chemical group a formal relation between these molecular descriptors recently obtained for an atom in a molecule using an approximate atomistic model [P. Senet and M. Yang, J. Chem. Sci. 117, 411 (2005)]. In addition, a practical ab initio computational scheme of the Coulomb hole and related local descriptors of reactivity of a molecular family having in common a similar fragment is presented. As a b…

Models Molecularchemistry.chemical_classificationQuantitative Biology::BiomoleculesQuantitative structure–activity relationshipBinding SitesChemistryAb initioGeneral Physics and AstronomyAmino acidModels ChemicalAb initio quantum chemistry methodsComputational chemistryMolecular descriptorMoleculeComputer SimulationDensity functional theoryAmino AcidsPhysical and Theoretical ChemistryAlgorithmsFragment molecular orbitalProtein BindingThe Journal of Chemical Physics
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QUANTITATIVE ANALYSIS OF SPATIAL INDICATORS IN THE CASE OF VARYING ADMINISTRATIVE BOUNDARIES

2021

The aim of the research is to develop methods that would allow comparingthe statistical parameters of Latviaat differing administrative divisions, thereby solvingthe problems that arise in the case of discrepancy of borders. As part of thework, the developed method was implemented in order to assess the suitabilityof the created tool for mathematical analysis of statistical parameters on Latvia. Theterritory examined in the work is Latvia; the discrepancy of borderswas examined by comparing the parish borders of 1935 with the parishes of 2000.Therefore it was necessary to create a transfer matrix in order to link theadministrative borders of both periods. The transfer matrix was prepared in…

Modifiable areal unit problemGeographyQuantitative analysis (finance)Statistical parameterRegional scienceGeneral Earth and Planetary SciencesValue (mathematics)General Environmental ScienceUnit (housing)ManagementRegional Formation and Development Studies
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On a Quantitative Measure for Modularity Based on Information Theory

2005

The concept of modularity appears to be crucial for many questions in the field of Artificial Life research. However, there have not been many quantitative measures for modularity that are both general and viable. In this paper we introduce a measure for modularity based on information theory. Due to the generality of the information theory formalism, this measure can be applied to various problems and models; some connections to other formalisms are presented.

Modular decompositionQuantitative measureGeneralitybusiness.industryComputer scienceArtificial lifeArtificial intelligenceMutual informationbusinessInformation theoryMeasure (mathematics)Modularity
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Processus d’innovation : une analyse sur les données CIS Européennes

2022

L’innovation est vu comme un déterminant important de la compétitivité des entreprises, elle joue donc le rôle crucial de moteur économique. Toute une série de mesure a été mis en place ces dernières décennies pour favoriser celle-ci. Pour autant, l’innovation n’est pas toujours source de croissance. Il apparait alors essentiel de comprendre le mécanisme d’innovation et son rendement, afin de guider au mieux l’action des politiques publiques.Il est très fréquent d’utiliser l’enquête communautaire sur l’innovation CIS (Community Innovation Survey) pour étudier le processus d’innovation. En effet, ces enquêtes constituent la principale source de statistiques sur l’innovation des entreprises e…

Modèle CDMAnalyse quantitativeInnovation[QFIN] Quantitative Finance [q-fin]
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Synthesis and molecular properties of donor–π-spacer–acceptor ynamides with up to four conjugated alkyne units

2010

A set of push-pull ynamides with up to four conjugated triple bonds has been synthesized and the molecular properties of these new carbon rods have been characterised showing effective intramolecular charge transfers and high values for the change of the electrical dipole moment after transition from the ground to the Franck-Condon excited state.

Molecular ConformationAlkynechemistry.chemical_elementConjugated systemCrystallography X-RayPhotochemistryCatalysisMaterials ChemistryPhysics::Atomic PhysicsPhysics::Chemical Physicschemistry.chemical_classificationQuantitative Biology::BiomoleculesChemistryMetals and AlloysGeneral ChemistryTriple bondAmidesAcceptorSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsElectric dipole momentAlkynesIntramolecular forceExcited stateCeramics and CompositesSpectrophotometry Ultravioletsense organsCarbonChemical Communications
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Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies

2019

The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. Therefore, it is not surprising that permeability of many different compounds has been measured through several in vitro and in vivo techniques. Moreover, many different in silico approaches have been used to identify the correlation between the structure of the permeants and their permeability, to reproduce the skin behavior, and to predict the ability of specific chemicals to permeate this barrier. A significant number of issues, like interlaboratory variability, experim…

Molecular dynamicComputer scienceGeneral Chemical EngineeringSkin AbsorptionSkin permeabilityLibrary and Information SciencesPrinciple component regressionPartial least square01 natural sciencesModels BiologicalQuantitative structure-property relationship0103 physical sciencesDrug DiscoveryAnimalsHumansComputer SimulationSite of originSkinIn silico prediction010304 chemical physicsChemical toxicityGeneral ChemistrySettore CHIM/08 - Chimica Farmaceutica0104 chemical sciencesComputer Science ApplicationsMultilinear regression010404 medicinal & biomolecular chemistryPharmaceutical PreparationsDrug deliverySkin permeabilityBiochemical engineeringAlgorithms
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Search compounds with antimicrobial activity by applying molecular topology to selected quinolones.

2003

Molecular topology was used to obtain substances with antimicrobial activity. Selected quinolones were employed to develop the corresponding connectivity functions and discriminant equation. Limiting functions were selected that allowed the discriminant function to more efficiently distinguish substances with and without antibacterial activity. Antibacterial tests were run to confirm the theoretically established activity.

Molecular modelStereochemistryClinical BiochemistryPharmaceutical ScienceQuantitative Structure-Activity RelationshipMicrobial Sensitivity TestsQuinolonesBiochemistryDiscriminant function analysisDrug DiscoveryAnimalsMolecular BiologyTopology (chemistry)Antibacterial agentBacteriaChemistryOrganic ChemistryDiscriminant AnalysisAntimicrobialAnti-Bacterial AgentsDiscriminantDrug DesignMolecular MedicineMolecular topologyBiological systemAntibacterial activityBioorganicmedicinal chemistry letters
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"Table 14" of "Search for magnetic monopoles and stable high-electric-charge objects in 13 TeV proton-proton collisions with the ATLAS detector"

2019

Selection efficiency as a function of transverse kinetic energy $E^\text{kin}_\text{T}=E_\text{kin}\sin\theta$ and pseudorapidity $|\eta|$ for $g=2g_\textrm{D}$ monopoles of mass 500 GeV.

Monopole13000.0Computer Science::Information RetrievalQuantitative Biology::Populations and EvolutionEFFComputer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing)High Energy Physics::ExperimentMEfficiencyNuclear Experiment
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"Table 19" of "Search for magnetic monopoles and stable high-electric-charge objects in 13 TeV proton-proton collisions with the ATLAS detector"

2019

Selection efficiency as a function of transverse kinetic energy $E^\text{kin}_\text{T}=E_\text{kin}\sin\theta$ and pseudorapidity $|\eta|$ for $g=2g_\textrm{D}$ monopoles of mass 3000 GeV.

Monopole13000.0Computer Science::Information RetrievalQuantitative Biology::Populations and EvolutionEFFComputer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing)High Energy Physics::ExperimentMEfficiencyNuclear Experiment
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"Table 17" of "Search for magnetic monopoles and stable high-electric-charge objects in 13 TeV proton-proton collisions with the ATLAS detector"

2019

Selection efficiency as a function of transverse kinetic energy $E^\text{kin}_\text{T}=E_\text{kin}\sin\theta$ and pseudorapidity $|\eta|$ for $g=2g_\textrm{D}$ monopoles of mass 2000 GeV.

Monopole13000.0Computer Science::Information RetrievalQuantitative Biology::Populations and EvolutionEFFComputer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing)High Energy Physics::ExperimentMEfficiencyNuclear Experiment
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