Search results for "Quotation"
showing 10 items of 18815 documents
La desamortización y enajenación del dominio de Sueca a finales del antiguo régimen: la presencia de Godoy como duque y señor de Sueca
2010
La concesión del ducado de Sueca a Manuel Godoy y la adquisición, mediante pública subasta del término y las pertenencias de esta villa, provocó importantes cambios en la jurisdicción y administración de la anterior posesión de la Orden de Montesa. La modificación en las condiciones de la compra, confirieron al Príncipe de la Paz los mismos privilegios de los que disfrutaba el Rey como Gran Maestre y Administrador Perpetuo, lo que acabó generando tensiones con los vecinos, terratenientes y el propio Ayuntamiento. The granting of the Duchy of Sueca to Manuel Godoy and the acquisition by auction of the territory and the belongings of this town, led to significant changes in the jurisdiction a…
How and Where are Drugs Absorbed?
2007
A drug must interact with its receptors at their action sites or therapeutic target to exert its pharmacological or toxic effects. Therefore, the absorption of drug is an essential step which determines pharmacologic effects of drug. This article focuses on the biological barriers that the drug must cross in order to enter the body, drug absorption mechanisms, and influence of physiological characteristics of the administration route on absorption rate and extent. Keywords: drugs; absorption mechanisms; administration routes; passive diffusion; endocytosis
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…
2014
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…
Electronic signature of the instantaneous asymmetry in the first coordination shell of liquid water
2013
Interpretation of the X-ray spectra of water as evidence for its asymmetric structure has challenged the conventional symmetric nearly-tetrahedral model and initiated an intense debate about the order and symmetry of the hydrogen bond network in water. Here, we present new insights into the nature of local interactions in water obtained using a novel energy decomposition method. Our simulations reveal that while a water molecule forms, on average, two strong donor and two strong acceptor bonds, there is a significant asymmetry in the energy of these contacts. We demonstrate that this asymmetry is a result of small instantaneous distortions of hydrogen bonds, which appear as fluctuations on …
From Graz to Göttingen: Neugebauer’s Early Intellectual Journey
2016
Otto Neugebauer’s early academic career was marked by a series of transitions. His interests shifted from physics to mathematics, and finally to the history of ancient mathematics and exact sciences. Yet even from his early years in Graz, Neugebauer was strongly attracted to the mathematical culture of Gottingen. When he arrived there in 1922, he quickly established a strong personal friendship with Richard Courant, the newly appointed Director of the Mathematics Institute. Neugebauer and Courant worked together closely up until 1933, when the Nazi government decimated the Gottingen scientific community. In this essay, Neugebauer’s historical work and his vision for a new approach to the st…
«Una gestazione lunga e travagliata» : la fondazione delle Università di Sassari e Cagliari
2020
Riassunto: Il lento iter di fondazione delle Universita di Sassari e di Cagliari vide impegnate le due citta sarde per l’ottenimento di una scuola di istruzione superiore per i propri giovani. La lunga gestazione fu il frutto di numerose richieste parlamentari e spasmodiche ricerche di finanziamenti che portarono, attraverso una lotta continua per la supremazia verso il riconoscimento di prima universita del regno e i controversi rapporti con la Compagnia di Gesu, al primo passo verso una istruzione di tipo accademico. Il presente contributo ricostruisce il processo di formazione delle universita dalle prime istanze poste in seno al Parlamento presieduto dal vicere Antonio de Cardona fino a…
Competency Orientation in Higher Education
2016
In recent years, higher education, particularly in Germany, has been marked by fundamental structural and programmatic changes after the implementation of the Bologna reform and the orientation towards competencies in the national standards for education, for instance, set forth by the Standing Conference of the Ministers of Education and Cultural Affairs in Germany. The quality of academic education and its social returns have received increasing attention, and endeavors to develop and implement fair assessments of students’ learning outcomes have revealed diverse challenges. In Germany and internationally, it is becoming increasingly important to define and assess in an objective, reliabl…
Promoting children’s participation: the role of teachers in preschool and primary school learning sessions
2010
The aim of this study is to provide insights into the social construction of participation in joint activities in Finnish preschool and primary school classrooms. The article deals with two issues: How do teachers promote participation in a preschool classroom as compared with a primary school classroom? What similarities and differences are found? It also considers the question of how the similarities contribute to the continuity from preschool to primary school in terms of participation. Based on observation data insights are provided into the interactions between teachers and children by using extracts from teacher‐led learning sessions. The teachers used a diversity of strategies to pro…
Teachers’ Perceptions of Relationship Enhancement Upon Implementation of the Social Emotional Learning Program in Latvia: Focus Group Study
2017
The goal of this study was to elicit and analyse teachers’ reflections on the benefits of the implementation of the SEL program in Latvia, both in regard to benefits for the students and in regard to benefits for themselves. The school-wide Latvia SEL program was initiated during the 2012–13 academic year and to date has been implemented in 41 Latvian schools. In order to ascertain the teachers’ views on issues of program effectiveness, seven focus groups were organised consisting of teachers who had participated in the SEL program implementation. Thematic analysis of the focus group discussions indicated that the teachers appreciate various benefits of the SEL program, but among the most p…
Preferencias de los y las estudiantes universitarias sobre el empleo desde una perspectiva de género
2015
Se presenta un estudio de encuesta sobre las preferencias que tiene el alumnado universitario al decidirse por un trabajo, lo que creen que les debe aportar y cómo debe ser la empresa en la que desearían trabajar en función de la variable género. Diferentes investigaciones, señalan que las personas desarrollan valores, expectativas y habilidades profesionales diferentes asociadas a la carrera y a la profesión en función del género. El objetivo de este trabajo es analizar los factores que llevan a los y las jóvenes a percibir el trabajo o profesión y determinar si dicha percepción es diferente por ser hombre o mujer. A través de un cuestionario ad hoc compuesto por 52 ítems de escala Likert…