Search results for "RÉTINE"

Rétine et lipides : de l'analyse à la physiopathologie

2016

Revue; Rétine et lipides : de l'analyse à la physiopathologie. Colloque du Collège National de Biochimie-Biologie Moléculaire Médicale (CNBBMM)

Place de l'électrophysiologie dans la recherche ophtalmologique chez l'animal

2011

Cholestérol-24S-hydroxylase (CYP46A1) et homéostasie du cholestérol dans la rétine en conditions physiologiques et pathologiques

2012

Cholesterol is the major sterol found in the retina. In its free form, cholesterol is present in all cell layers of the retina, whereas cholesteryl esters mainly accumulate at the basement of the retinal pigment epithelium. The intrinsic capacity of the retina to synthetize cholesterol appears limited. Some extra-retinal pathways actively participate to cholesterol uptake to the retina. Müller glial cells may contribute to cholesterol supply to retinal neurons, especially for synaptic formation. Cholesterol accumulation or conversely deficiency have deleterious consequences on neuron survival. Maintaining the equilibrium between cholesterol supply and neosynthesis in the one hand and choles…

Plasmalogen metabolism in retinal glial cells : interaction between cells during normal or pathological vascular development

2017

Retinal vascular disorders such as retinopathy of prematurity (ROP), diabetic retinopathy or age-related macular degeneration represent the first cause of vision loss at all ages in industrialized countries. Many epidemiological or animal studies have shown the involvement of polyunsaturated fatty acids (PUFA) in the regulation of vascular development and more specifically the beneficial properties of omega 3 PUFA (n-3 PUFA) against pathological vascularization. Those PUFA are esterified on glycerophospholipids (GP). GP are the primary constituents of the lipid bilayer of cell membranes. PUFA can be also esterified on a specific class of GP, called plasmalogens. Plasmalogens are characteriz…

Involvement of plasmalogens and polyunsaturated fatty acids in the pathogenesis of glaucoma

2013

Le rôle des lipides dans les maladies de l’œil

2012

Le rôle des lipides dans les maladies de l’œil

Lipides : qui êtes-vous ?

2019

Actualités en micronutrition. Partie III : nouvelles données sur oméga-3 et angiogenèse

2017

The mechanisms of the action of omega-3s in the retina

2013

Age-related Macular Degeneration (AMD) is the leading cause of visual loss in Western countries after the age of 50y. Based on large-scale epidemiologic studies, it appears now as evident that omega-3 polyunsaturated fatty acids (PUFAs) provide benefits in preventing both, early and late stages of AMD. The aim of this paper is to summarize the knowledge about the biological mechanisms by which omega-3 PUFAs may be protective for the retina. The content of this presentation will range from biochemical data about the occurrence of omega-3 PUFAs in retinal cell membranes to results from cellular and animal studies showing that omega-3 PUFAs can influence processes involved in signal transducti…

Loss of rod sensitivity and gene expression changes in the retina of fructose-fed insulin-resistant mice

2012

Purpose: Metabolic syndrome is of major concern in Western countries since it predisposes individuals to the development of diabetes. Insulin resistance is one of the biochemical features of the metabolic syndrome. Fructose feeding has been used to elicit insulin resistance in rodents. Our purpose was to characterize the functional and gene expression changes in the retina after long term feeding mice with a fructose-enriched diet.Methods: Control and ApoB100,LDLR-/- mice, a murine model of aging of the human retina, were fed with a 60%-rich fructose diet for 8 months. Scotopic single flash and Flicker electroretinograms were recorded to monitor the response of the retina to flash stimuli. …