6533b86ffe1ef96bd12cdfb8
RESEARCH PRODUCT
The mechanisms of the action of omega-3s in the retina
Niyazi Acarsubject
genetic structuresrétineInflammationBiologymedicine.disease_cause03 medical and health sciences0302 clinical medicine[SDV.IDA]Life Sciences [q-bio]/Food engineeringmedicine[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory OrganslipideComputingMilieux_MISCELLANEOUSchemistry.chemical_classificationRetinaacide grasfood and beveragesGeneral MedicineMacular degenerationmedicine.diseaseeye diseasesOphthalmologymedicine.anatomical_structureBiochemistrychemistry[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory OrgansApoptosis[ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organs030221 ophthalmology & optometrylipids (amino acids peptides and proteins)sense organsAnimal studiesmedicine.symptomSignal transductionNeuroscience030217 neurology & neurosurgeryOxidative stressPolyunsaturated fatty aciddescription
Age-related Macular Degeneration (AMD) is the leading cause of visual loss in Western countries after the age of 50y. Based on large-scale epidemiologic studies, it appears now as evident that omega-3 polyunsaturated fatty acids (PUFAs) provide benefits in preventing both, early and late stages of AMD. The aim of this paper is to summarize the knowledge about the biological mechanisms by which omega-3 PUFAs may be protective for the retina. The content of this presentation will range from biochemical data about the occurrence of omega-3 PUFAs in retinal cell membranes to results from cellular and animal studies showing that omega-3 PUFAs can influence processes involved in signal transduction, oxidative stress, apoptosis or inflammation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-18 |