Search results for "R1"

Suullisen perinteen pelastajista kulttuuriperinnön tuottajiksi ja tulkitsijoiksi : Suomalaisen Kirjallisuuden Seuran arkiston kouluyhteistyö 1800-luv…

2019

Tarkastelen artikkelissa Suomalaisen Kirjallisuuden Seuran (SKS) arkiston suhdetta kouluihin: sitä, missä rooleissa opettajat ja oppilaat ovat toimineet perinteen ja nykykulttuurin tallentamisessa 1800-luvulta tähän päivään ja millaisia tavoitteita SKS:llä on eri aikoina ollut koulujen kanssa tehdylle yhteistyölle. SKS perustettiin vuonna 1831 edistämään suomen kielen ja suomenkielisen kirjallisuuden asemaa. Kansanperinteen keruu ja tallentaminen kuuluivat seuran toimintaan alusta lähtien. Seuran kokoelmat ovat karttuneet kansalaisaktiivisuuden ansiosta ja erityisesti 1930-luvulla organisoidussa arkiston keruuverkossa opettajat olivat vahvasti edustettuina. Aineistoja kertyi myös koululaisi…

Identificación y caracterización de factores implicados en la biogénesis de la RNA polimerasa II en Saccharomyces cerevisiae

2014

INTRODUCCIÓN La transcripción es el proceso de síntesis enzimática de un RNA a partir de una secuencia complementaria de DNA. En eucariotas, la transcripción de los genes que codifican proteínas la lleva a cabo la RNA polimerasa II (RNA pol II), junto con una gran cantidad de factores auxiliares que participan en el proceso actuando a diferentes niveles. Para que la RNA pol II inicie la transcripción se requiere la formación del complejo pre-inicio (PIC). Uno de los pasos clave en la regulación del inicio de la transcripción es la formación del PIC. En este proceso se ha visto implicado el regulador transcripcional NC2 (cofactor negativo 2), que actúa bloqueando el ensamblaje del PIC. Ademá…

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ADAR1, a promising “protecting” biomarker in oral squamous cell carcinoma

2019

The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?

2002

International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …

Cerebral plasmogens and aldehydes in senescence-accelerated mice P8 and R1 : Acomparison between weaned, adult and aged mice

2006

International audience; In contrast with senescence-accelerated mice R1, SAM P8 show abnormal aging characteristics. Changes occurring during aging could be mainly caused by free radical reactions. The brain is a plasmalogen-rich tissue. These particular phospholipids may act as endogenous antioxidants, be oxidized and release long chain aldehydes and α-hydroxyaldehydes during oxidative stress. The aim of this study was to examine by GC/MS the age- and strain-related levels of plasmalogens, aldehydes and α-hydroxyaldehydes in brain homogenates of SAM P8 and R1 at weaning, 5 months and 9 months of age in order to better understand the differences between both strains. In SAM R1, the evolutio…

Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents.

2016

Four ruthenium complexes of clinically used zinc ionophore pyrithione and its oxygen analog 2-hydroxypyridine N-oxide were prepared and evaluated as inhibitors of enzymes of the aldo–keto reductase subfamily 1C (AKR1C). A kinetic study assisted with docking simulations showed a mixed type of inhibition consisting of a fast reversible and a slow irreversible step in the case of both organometallic compounds 1A and 1B. Both compounds also showed a remarkable selectivity towards AKR1C1 and AKR1C3 which are targets for breast cancer drug design. The organoruthenium complex of ligand pyrithione as well as pyrithione itself also displayed toxicity on the hormone-dependent MCF-7 breast cancer cell…

Rapid, cost-effective, sensitive and quantitative detection of Acinetobacter baumannii from pneumonia patients

2011

Background and Objectives: Pneumonia with Acinetobacter baumannii has a major therapeutic problem in health care settings. Decision to initiate correct antibiotic therapy requires rapid identification and quantification of organism. The aim of this study was to develop a rapid and sensitive method for direct detection of A. baumannii from respiratory specimens. Materials and Methods: A Taqman real time PCR based on the sequence of blaoxa-51 was designed and used for direct detection of A. baumannii from 361 respiratory specimens of patients with pneumonia. All specimens were checked by conventional bacteriology in parallel. Results: The new real time PCR could detect less than 200 cfu per m…

Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.

2020

Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia (AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most curable form of AML. The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review of these translocations, discussing 15 different variants. Reviewed genes involved in APL variants include: ZBTB16, NPM, NuMA, STAT5b, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMDTS17, STAT3, and TFG. The genotypic and phenotypic …

Relation between health literacy, self-care and adherence to treatment with oral anticoagulants in adults: a narrative systematic review

2018

Background Oral anticoagulants (OAC) are widely used in patients with cardiovascular diseases. However, for optimal OAC self-care patients must have skills, among which health literacy (HL) is highlighted. We aimed to describe the relation between HL and self-care in cardiovascular patients on OAC treatment. Methods Electronic searches were carried out in the PubMed, Scopus, Embase, CINAHL, Web of Science, Cochrane Library, SciELO, IME-Biomedicina, CUIDEN Plus and LILACS databases, limited to Spanish and English language and between January 2000–December 2016. Papers reported on adults older than 18 years, taking OAC by themselves for at least three months. PRISMA guidelines were used for p…