Search results for "R1"
showing 10 items of 1016 documents
Términos persas en escritos anatómicos árabes
1995
The. A. explains the meaning of some Iranian technical words, which appear in anatomical Arab works. They are interesting, not only because they are nearly unknown, but also because they are an evidence of the influence of Iranian culture on the rise of Arabian scientific medicine, and so an encouragement to further investigation on this subject.
El balneario de Bellús en los siglos XVIII y XIX, a través de los tratados de hidrología médica
1997
The present work aims to explain the situation of the valencian bathing place in Bellús, through some treatises of medical hydrology from the 18th and 19th centuries which belong to the Library and Historico-medical Museum of Valencia. The architectural and technical conditions of the building are described, as well as the methods of water analysis and the therapeutical use of water.
The treatment of madness in the nineteenth and twentieth centuries: discourses about curability in Spanish mental health care, 1890-1917
2016
Resumen En el trabajo se estudian los discursos sobre la cura que elaboraron los médicos mentalistas españoles en la transición del siglo XIX al XX. Si en las décadas de los años 1870 y 1880 el discurso preponderante promulgado por los médicos pertenecientes a instituciones privadas era extremadamente optimista, posteriormente cambió y se orientó hacia un mayor pesimismo terapéutico. Sin embargo, dadas las necesidades profesionales de los frenópatas, siguieron mostrando una confianza más o menos firme hacia las capacidades terapéuticas de la psiquiatría. La recepción de las nuevas nosologías, como la de Kraepelin, estuvo condicionada, en parte, por la actitud hacia la cura de los médicos me…
Engineering of sugar transporters for improvement of xylose utilization during high-temperature alcoholic fermentation in Ogataea polymorpha yeast
2020
Abstract Background Xylose transport is one of the bottlenecks in the conversion of lignocellulosic biomass to ethanol. Xylose consumption by the wild-type strains of xylose-utilizing yeasts occurs once glucose is depleted resulting in a long fermentation process and overall slow and incomplete conversion of sugars liberated from lignocellulosic hydrolysates. Therefore, the engineering of endogenous transporters for the facilitation of glucose-xylose co-consumption is an important prerequisite for efficient ethanol production from lignocellulosic hydrolysates. Results In this study, several engineering approaches formerly used for the low-affinity glucose transporters in Saccharomyces cerev…
Proteomic Analyses of Human Cytomegalovirus Strain AD169 Derivatives Reveal Highly Conserved Patterns of Viral and Cellular Proteins in Infected Fibr…
2014
Human cytomegalovirus (HCMV) particle morphogenesis in infected cells is an orchestrated process that eventually results in the release of enveloped virions. Proteomic analysis has been employed to reveal the complexity in the protein composition of these extracellular particles. Only limited information is however available regarding the proteome of infected cells preceding the release of HCMV virions. We used quantitative mass spectrometry to address the pattern of viral and cellular proteins in cells, infected with derivatives of the AD169 laboratory strain. Our analyses revealed a remarkable conservation in the patterns of viral and of abundant cellular proteins in cells, infected for 2…
Hypnosis, Animal Magnetism, and Monstrosity in late Nineteenth Century English Literature
2019
We will explore the literary image of animal magnetism and hypnosis through the analysis of two works of fiction: the novels Richard Marsh’s The Beetle: A Mystery (1897) and Bram Stoker’s Dracula (1897). During all the 19th century and mainly at its last, many authors used animal magnetism and hypnosis in their fictional creations in an environmental or plot way, so much that Arthur Quiller-Couch, an important literary critic of the nineteenth century, spoke about the emergence of a new literary subgenre that he called “hypnotic fiction”. Starting from the idea that in this mesmeric and hypnotic fiction literature you can clearly trace differentiated stereotypes of magnetizers and hypnotist…
Digital Vitruvius, or an elogy of the equilateral triangle
2012
On interpretation of an architectural project, triangle’s form generally refers both to plans of organic architecture and to fronts of Romanesque and Gothic churches. This wonderful form, that contains God’s eye, is, according to Vitruvius, the geometric generative principle of the Roman Theatre. Everybody knows that De Architectura arrived to us without images; in the past there were innumerable interpretations, from editio princeps (1486). A digital transcriptions, that follows side by side a Vitruvius’ book’s translation, highlights the compositional process that defines that the equilateral triangle is the geometric element that give origin to the composition of theatre.
A gated material as immunosensor for in-tissue detection of IDH1-R132H mutation in gliomas
2021
[EN] A nanodevice consisted on nanoporous anodic alumina (NAA) supports functionalized with specific and selective antibody-based gatekeepers for the detection of IDH1-R132H mutant enzyme is here reported. Molecular profile and tissue mutations of the tumours (such as IDH1/IDH2 mutations in gliomas) are a great source of information that already make a difference in terms of prognosis and prediction of response to combined therapy. However, standardized methodologies to determine this mutation are time-consuming and cannot provide information before or during surgical intervention, which significantly limits their utility in terms of intraoperative decisionmaking. To solve this limitation, …
Nouvelles perspectives concernant la structure et la fonction du domaine carboxyl terminal de Hfq
2015
Accumulating evidence indicates that RNA metabolism components assemble into supramolecular cellular structures to mediate functional compartmentalization within the cytoplasmic membrane of the bacterial cell. This cellular compartmentalization could play important roles in the processes of RNA degradation and maturation. These components include Hfq, the RNA chaperone protein, which is involved in the post-transcriptional control of protein synthesis mainly by the virtue of its interactions with several small regulatory ncRNAs (sRNA). The Escherichia coli Hfq is structurally organized into two domains. An N-terminal domain that folds as strongly bent β-sheets within individual protomers to…
Etude de la régulation transcriptionnelle des lymphocytes T CD4 dans un contexte de cancer : application en immunothérapie anticancéreuse
2015
Immune surveillance of tumors is based on the ability of effector cells of the immune system to detect and eliminate the cancer cells. Notwithstanding, the complete and spontaneous regression of established cancers was observed only in very few cases. The failure of cancer resolution by the immune system could result from the combination of several factors: i) inadequate immune response related to a low tumor immunogenicity, ii) incompetent immune system consecutively to induced or acquired immunodeficiencies and iii) the selection of resistant tumor variants able to thwart immune surveillance or subverting immune responses. Developing novel cancer immunotherapy strategies leading to potent…