Search results for "R1"

The impact of globalization on regional development and competitiveness: cases of selected regions

2019

International audience; The objective of this study is to conduct an analysis of regional development and competitiveness in the EU and Latvia under current conditions of economic globalization. This paper makes an attempt to evaluate a theory of regional development and regional competitiveness concept in relation to regional competitiveness in the light of current global economic changes. The authors emphasise that the regional development is based on competitive advantages, which has been a subject of fundamental research by Michal Porter and that serves as a basis for the current scientific methodology to assess competitiveness of regions and countries. The authors support a view of man…

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-dr…

2017

Background Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast growth factor receptors (FGFRs) constitute a promising therapy target in several types of malignancies including lung cancer. The clinically approved small-molecule FGFR inhibitor nintedanib exerts strong cytotoxicity in FGFR-driven lung cancer cells. However, subcellular pharmacokinetics of this compound and its impact on therapeutic efficacy remain obscure. Methods 3-dimens…

Teema edellä puuhun?

2018

The determinants of stakeholder engagement in digital platforms

2018

Abstract Consumer engagement has been heralded as strategic in facilitating sales growth, competitive advantage, and profitability. Expanding the notion of consumer engagement to the stakeholder context, this study examines the determinants of multi-stakeholder digital engagement. Based on a digital setting (Expo2015), this study collected all the social media posts (n = 984) in the Facebook page with restricted access to the stakeholders involved in the event. Initial regression results suggest that the presence of transformation, in terms of activation of creative resource integration in posts, is a strong predictor of compliant and interactive engagement. Fuzzy-set qualitative comparativ…

Immunological Probes for the Bradykinin B2 Receptor. A Toolbox

1997

Publisher Summary This chapter provides an overview of the immunological tools for bradykinin (BK) B 2 receptor. Receptors for kinins are classified as two major subtypes, B 1 and B 2 , although other subtypes may exist. B 1 receptors are activated by carboxyterminally truncated kinins, whereas BK and kallidin (Lys-BK) are B 2 receptor agonists. Molecular cloning has revealed the primary structures of B 1 and B 2 receptors and identified them as members of the G protein-coupled receptor family, characterized by seven membrane-spanning α-helices. In some tissues, B 1 receptor expression is induced by cytokines, such as interleukin-1, whereas the B 2 receptor is thought to be expressed consti…

Some characterizations of algebras with involution with polynomial growth of their codimensions

2018

Let A be an associative algebra endowed with an involution ∗ of the first kind and let c ∗n (A) denote the sequence of ∗-codimensions of A. In this paper, we are interested in algebras with involution such that the ∗-codimension sequence is polynomially bounded. We shall prove that A is of this kind if and only if it satisfies the same identities of a finite direct sum of finite dimensional algebras with involution A i , each of which with Jacobson radical of codimension less than or equal to one in A i . We shall also relate the condition of having polynomial codimension growth with the sequence of cocharacters and with the sequence of colengths. Along the way, we shall show that the multi…

Interactions, spillovers de connaissance et croissance des villes européennes. Faut-il préférer la géographie, le climat institutionnel ou les réseau…

2013

Knowledge spillovers within urban economies are also sources of spillovers between cities. We examine how knowledge spillovers influenced the economic growth of 82 European metropolises over the 1990-2005 period. We model knowledge spillovers between cities on the basis of five specific interaction patterns based on geography, networks of multinational firms in advanced services, institutional climate and two combinations of these factors. Spatial models are estimated to detail the effects of growth factors in terms of spillovers and externalities. We show that spillovers are local rather than global and that interactions among cities accelerate the convergence process based on gross value …

Note about the concept of ‘Net Multipliers'

2002

International audience; Net multipliers, as introduced by Oosterhaven and Stelder (2002) accept outputs as entries instead of final demand. They are found by multiplying ordinary multipliers by the final demand ratio over the sector's output. This pragmatic solution suffers from ratio instability over time. The alternative net multipliers proposed here are based on the interpretation of the Leontief inverse matrix for the effects generated at each round. The new solution is not sensitive to the size of impacts. Now net multiplier is equal to the corresponding ordinary multiplier minus one, and the ordering of multipliers is unchanged.

On Boolean topological methods of structural analysis

2001

The properties of Boolean methods of structural analysis are used to analyze the intern structure of linear or non linear models. Here they are studied on the particular example of qualitative methods of input-output analysis. First, it is shown that these methods generate informational problems like biases when working in money terms instead of percentages, losses of information, increasing of computation time, and so on. Second, considering three ways to do structural analysis, analysis from the inverse matrix, from the direct matrix and from layers (intermediate flow matrices), these methods induce topological problems; the adjacency of the adjacency cannot be defined from the inverse ma…

Is there a Market Value for Energy Performance in a Local Private Housing Market ? An efficiency analysis approach

2018

This paper aims to find evidence of a “green value” in a local housing market using notarial data on a small urban area in France. We use frontier functions, an original approach that departs from customary hedonistic regressions, to model housing market prices as a production set bordered by an efficiency frontier estimated by Data Envelopment Analysis (DEA). The paper tests if difference in prices (i.e. the distance from the frontier) can be explained by energy performance measured as a normalized categorical ascending kWh/m²/year grade (or Energy Performance Certificate -EPC). We show that there is significative evidence for energy performance's market value. The “Green Property Value” i…