Search results for "R1"
showing 10 items of 1016 documents
Three (marginal?) questions regarding convergence
2004
This paper focuses on three (marginal?) questions surrounding the analysis of economic convergence and uses Spanish provinces as a means of illustration. The three questions in hand are the following: (i) given that the geographical units of analysis are usually quite different in economic size, is the weighting of economic units relevant in convergence analysis? (ii) the average per capita income of a given region, or country, is the first moment in the distribution of income, but what about the second moment, inequality? Have we converged in inequality? and (iii) an aggregate welfare index must take into account, at least, the evolution of the first two moments of the distribution of inco…
Unique Microbial Catabolic Pathway for the Human Core N-Glycan Constituent Fucosyl-α-1,6-N-Acetylglucosamine-Asparagine
2020
The survival of commensal bacteria in the human gut partially depends on their ability to metabolize host-derived molecules. The use of the glycosidic moiety of N-glycoproteins by bacteria has been reported, but the role of N-glycopeptides or glycoamino acids as the substrates for bacterial growth has not been evaluated. We have identified in Lactobacillus casei strain BL23 a gene cluster (alf-2) involved in the catabolism of the glycoamino acid fucosyl-α-1,6-N-GlcNAc-Asn (6′FN-Asn), a constituent of the core-fucosylated structures of mammalian N-glycoproteins. The cluster consists of the genes alfHC, encoding a major facilitator superfamily (MFS) permease and the α-l-fucosidase AlfC, and t…
Landis-type conjecture for the half-Laplacian
2023
In this paper, we study the Landis-type conjecture, i.e., unique continuation property from infinity, of the fractional Schrödinger equation with drift and potential terms. We show that if any solution of the equation decays at a certain exponential rate, then it must be trivial. The main ingredients of our proof are the Caffarelli-Silvestre extension and Armitage’s Liouville-type theorem. peerReviewed
German and Austrian occupant literature on the Sami in Norway and Lapland – “Harmless” minority, a resource, and well-off “reindeer kings”
2020
Source at http://urn.fi/URN:NBN:fi:jyu-202006234344. In previous research on the history of the Second World War in Finland and Norway, relations between the German and Austrian occupying forces and the Sami people have generally been considered to be good. The occupant gaze upon the Sami has been interpreted as exoticizing and “touristic”. Historical encounters and the Sami position in the literary discourse are discussed and explained in this article, using a selection of German and Austrian wartime and post-war literature. The discursive reading the sources bear evidence of multiple ways of relating to the Sami, from benign to racializing; from demeaning to one filled with surprise at un…
Landscapes of loss and destruction: : Sámi elders’ childhood memories of the second world war
2019
The so-called Lapland War between Finland and Germany at the end of the Second World War led to a mass-scale destruction of Lapland. Both local Finnish residents and the indigenous Sámi groups lost their homes, and their livelihoods suffered in many ways. The narratives of these deeply traumatic experiences have long been neglected and suppressed in Finland and have been studied only recently by academics and acknowledged in public. In this text, we analyze the interviews with four elders of one Sámi village, Vuotso. We explore their memories, from a child’s perspective, scrutinizing the narration as a multilayered affective process that involves sensual and embodied dimensions of memory. ©…
An Interview with the Brother, Micheál Ó Nualláin
2015
This interview with Micheál Ó Nualláin, Brian O’Nolan’s brother and the only surviving member of his generation of the family, was conducted on 10 June 2014 in Monkstown, County Dublin. Its purpose was to obtain information about Brian O’Nolan’s private library at the John J. Burns Library, Boston College; the archive being the focal point of this issue of The Parish Review. It was Micheál who sold the last of his brother’s effects to Boston College in May 1997 and therefore he is in a position to answer questions about the purchase of the library, its contents and their provenance, and the reading practices of Brian and Evelyn O’Nolan.To read the article, click Download or View PDF.
Light and Primary Production Shape Bacterial Activity and Community Composition of Aerobic Anoxygenic Phototrophic Bacteria in a Microcosm Experiment
2020
ABSTRACT Phytoplankton is a key component of aquatic microbial communities, and metabolic coupling between phytoplankton and bacteria determines the fate of dissolved organic carbon (DOC). Yet, the impact of primary production on bacterial activity and community composition remains largely unknown, as, for example, in the case of aerobic anoxygenic phototrophic (AAP) bacteria that utilize both phytoplankton-derived DOC and light as energy sources. Here, we studied how reduction of primary production in a natural freshwater community affects the bacterial community composition and its activity, focusing primarily on AAP bacteria. The bacterial respiration rate was the lowest when photosynthe…
Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Infl…
2015
Protein cysteines can form transient disulfides with glutathione (GSH), resulting in the production of glutathionylated proteins, and this process is regarded as a mechanism by which the redox state of the cell can regulate protein function. Most studies on redox regulation of immunity have focused on intracellular proteins. In this study we have used redox proteomics to identify those proteins released in glutathionylated form by macrophages stimulated with lipopolysaccharide (LPS) after pre-loading the cells with biotinylated GSH. Of the several proteins identified in the redox secretome, we have selected a number for validation. Proteomic analysis indicated that LPS stimulated the releas…
Liver fibrosis: Direct antifibrotic agents and targeted therapies
2018
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases. Moreover, drugs that would speed…
Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease
2021
Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-sco…