Search results for "R1"
showing 10 items of 1016 documents
Unique clockwork in photoreceptor of rat
2010
In mammals, the retina contains a clock system that oscillates independently of the master clock in the suprachiasmatic nucleus and allows the retina to anticipate and to adapt to the sustained daily changes in ambient illumination. Using a combination of laser capture micro-dissection and quantitative PCR in the present study, the clockwork of mammalian photoreceptors has been recorded. The transcript amounts of the core clock genes Clock, Bmal1, Period1 (Per1), Per3, Cryptochrome2, and Casein kinase Ie in photoreceptors of rat retina have been found to undergo daily changes. Clock and Bmal1 peak with Per1 and Per3 around dark onset, whereas Casein kinase Ie and Cryptochrome2 peak at night…
The medicalization of suicide in 19th century Spain: theoretical, professional and cultural aspects
2012
This paper analyzes the medicalization process of suicide in Spain during the 19th century. It describes the transition of suicide seen as an act of free will to a model, developed by mental doctors, which considered it a pathological behavior. Against this model, other conservative positions from the fields of Law and Medicine continued to defend the traditional view. The initial interest of mental medicine regarding the social aspects of suicide was developed during this period. The social factor that authors considered to be the most influential to suicide was the loss of religious ideas, which was understandable considering that religion was very present in Spanish science and society t…
[Los laboratorios de la Junta para Ampliación de Estudios e Investigaciones Científicas (J.A.E.) y la Residencia de Estudiantes (1912-1939)].
2007
La política de jóvenes pensionados científicos en el extranjero desarrollada por la JAE tuvo un complemento importante en la puesta en marcha de una serie de pequeños laboratorios científicos y centros de investigación agrupados principalmente en el Instituto Nacional de Ciencias y la Residencia de Estudiantes. El presente artículo aporta una perspectiva general de la labor realizada por algunos de esos laboratorios, sus principales protagonistas y grupos de investigación, particularmente los relacionados con las investigaciones biomédicas. No se analiza la labor del Instituto Cajal o el Museo de Ciencias Naturales, que son objeto de otras contribuciones en este mismo número monográfico. Se…
Transcriptional Rewiring, Adaptation, and the Role of Gene Duplication in the Metabolism of Ethanol of Saccharomyces cerevisiae
2020
Ethanol is the main by-product of yeast sugar fermentation that affects microbial growth parameters, being considered a dual molecule, a nutrient and a stressor. Previous works demonstrated that the budding yeast arose after an ancient hybridization process resulted in a tier of duplicated genes within its genome, many of them with implications in this ethanol “produce-accumulate-consume” strategy. The evolutionary link between ethanol production, consumption, and tolerance versus ploidy and stability of the hybrids is an ongoing debatable issue. The implication of ancestral duplicates in this metabolic rewiring, and how these duplicates differ transcriptionally, remains unsolved. Here, we …
Valta, tulkinta ja eettisyys : historiantutkijan yhteiskunnallinen rooli
2018
Arvio teoksesta Lidman, Satu, Anu Koskivirta & Jari Eilola (toim.). Historiantutkimuksen etiikka. Helsinki: Gaudeamus. 2017. 288 s. ISBN 978-952- 495-442-6. Book review: Lidman, Satu, Anu Koskivirta & Jari Eilola (toim.). Historiantutkimuksen etiikka. Helsinki: Gaudeamus. 2017. 288 s. ISBN 978-952- 495-442-6.
Exhaled metabolite patterns to identify recent asthma exacerbations
2021
Asthma is a chronic respiratory disease that can lead to exacerbations, defined as acute episodes of worsening respiratory symptoms and lung function. Predicting the occurrence of these exacerbations is an important goal in asthma management. The measurement of exhaled breath by electronic nose (eNose) may allow for the monitoring of clinically unstable asthma and exacerbations. However, data on its ability to perform this is lacking. We aimed to evaluate whether eNose could identify patients that recently had asthma exacerbations. We performed a cross-sectional study, measuring exhaled breath using the SpiroNose in adults with a physician-reported diagnosis of asthma. Patients were randoml…
W.H. Walsh’s Idea of Colligation Reconsidered
2020
Essay on: W.H. Walsh´s Idea of Colligation Reconsidered
Science and law in the time of cholera: the mystery of the biscuits in Torroja (1865)
2018
By focussing on a case of collective poisoning in 1865, four features of forensic cultures are analysed: technologies for detection, authorized voices, regulations in action and the predominant social anxieties. Local newspapers and archival documents kept in the medical academies of Barcelona and Madrid are analysed. The analysis shows the tensions between various types of proof employed in legal medicine and the ambiguities between epidemic diseases and poisoning accidents. In the first section, I review the fears caused by the cholera epidemic in 1865, which was the first explanation of the accident. The changes of popular perception are also discussed by analysing contemporary newspaper…
Inverse problems for a fractional conductivity equation
2020
This paper shows global uniqueness in two inverse problems for a fractional conductivity equation: an unknown conductivity in a bounded domain is uniquely determined by measurements of solutions taken in arbitrary open, possibly disjoint subsets of the exterior. Both the cases of infinitely many measurements and a single measurement are addressed. The results are based on a reduction from the fractional conductivity equation to the fractional Schr\"odinger equation, and as such represent extensions of previous works. Moreover, a simple application is shown in which the fractional conductivity equation is put into relation with a long jump random walk with weights.
”Siellä missä miehiä tehdään” – Mika Waltarin nuoruuden tuotanto ja sen vastaanotto sukupuolten rakentamisen paikkoina
2013
Arvio teoksesta Järvelä, Juha: Waltari ja sukupuolten maailmat. Helsinki: Avain. 2013. 265 s.