Search results for "R1"
showing 10 items of 1016 documents
Restoration and Enhancement of Historical Stereo Photos
2021
Restoration of digital visual media acquired from repositories of historical photographic and cinematographic material is of key importance for the preservation, study and transmission of the legacy of past cultures to the coming generations. In this paper, a fully automatic approach to the digital restoration of historical stereo photographs is proposed, referred to as Stacked Median Restoration plus (SMR+). The approach exploits the content redundancy in stereo pairs for detecting and fixing scratches, dust, dirt spots and many other defects in the original images, as well as improving contrast and illumination. This is done by estimating the optical flow between the images, and using it …
Classification of current anticancer immunotherapies.
2014
© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
2015
Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding …
Analysis of Multilocus Sequence Typing and Virulence Characterization of Listeria monocytogenes Isolates from Chinese Retail Ready-to-Eat Food
2016
Eighty Listeria monocytogenes isolates were obtained from Chinese retail ready-to-eat (RTE) food and were previously characterized with serotyping and antibiotic susceptibility tests. The aim of this study was to characterize the subtype and virulence potential of these L. monocytogenes isolates by multilocus sequence typing (MLST), virulence-associate genes, epidemic clones (ECs), and sequence analysis of the important virulence factor: internalin A (inlA). The result of MLST revealed that these L. monocytogenes isolates belonged to 14 different sequence types (STs). With the exception of four new STs (ST804, ST805, ST806, and ST807), all other STs observed in this study have been associat…
Evolutionary Study of Disorder in Protein Sequences
2020
Intrinsically disordered proteins (IDPs) contain regions lacking intrinsic globular structure (intrinsically disordered regions, IDRs). IDPs are present across the tree of life, with great variability of IDR type and frequency even between closely related taxa. To investigate the function of IDRs, we evaluated and compared the distribution of disorder content in 10,695 reference proteomes, confirming its high variability and finding certain correlation along the Euteleostomi (bony vertebrates) lineage to number of cell types. We used the comparison of orthologs to study the function of disorder related to increase in cell types, observing that multiple interacting subunits of protein comple…
Distinctive Evasion Mechanisms to Allow Persistence of Borrelia burgdorferi in Different Human Cell Lines
2021
Lyme borreliosis is a multisystemic disease caused by the pleomorphic bacteria of the Borrelia burgdorferi sensu lato complex. The exact mechanisms for the infection to progress into a prolonged sequelae of the disease are currently unknown, although immune evasion and persistence of the bacteria in the host are thought to be major contributors. The current study investigated B. burgdorferi infection processes in two human cell lines, both non-immune and non-phagocytic, to further understand the mechanisms of infection of this bacterium. By utilizing light, confocal, helium ion, and transmission electron microscopy, borrelial infection of chondrosarcoma (SW1353) and dermal fibroblast (BJ) c…
''Dual'' gravity: Using spatial econometrics to control for multilateral resistance.
2007
We propose a quantity-based `dual' version of the gravity equation that yields an estimating equation with both cross-sectional interdependence and spatially lagged error terms. Such an equation can be concisely estimated using spatial econometric techniques. We illustrate this methodology by applying it to the Canada-U.S. data set used previously, among others, by Anderson and van Wincoop (2003) and Feenstra (2002, 2004). Our key result is to show that controlling directly for spatial interdependence across trade flows, as suggested by theory, significantly reduces border effects because it captures `multilateral resistance'. Using a spatial autoregressive moving average specification, we …
Growth and convergence in Africa: The impact of spatial effects
2010
The aim of this paper is to study the impact of spatial effects on convergence process in Africa over the period 1975-2000. Taking into account these effects through the methodology of Exploratory Spatial Data Analysis (ESDA) and spatial econometrics, we focus on the geographical dimension of economic convergence of African countries. This allows us to deal with spatial autocorrelation which is a consequence of econometric interdependences due to geographic spillovers. Indeed, countries economic performance hides specific geographical patterns providing information on the importance of location on economic dynamics. Our results prove the existence of convergence process in Africa through a …
Pareto or log-normal? A recursive-truncation approach to the distribution of (all) cities
2012
Traditionally, it is assumed that the population size of cities in a country follows a Pareto distribution. This assumption is typically supported by finding evidence of Zipf's Law. Recent studies question this finding, highlighting that, while the Pareto distribution may fit reasonably well when the data is truncated at the upper tail, i.e. for the largest cities of a country, the log-normal distribution may apply when all cities are considered. Moreover, conclusions may be sensitive to the choice of a particular truncation threshold, a yet overlooked issue in the literature. In this paper, then, we reassess the city size distribution in relation to its sensitivity to the choice of truncat…
Smart Cities and a Stochastic Frontier Analysis: A Comparison among European Cities
2013
The level of interest in smart cities is growing, and the recent literature on this topic (Holland, 2008; Caragliu et al., 2009, Nijkamp et al., 2011 and Lombardi et al., 2012) identifies a number of factors that characterise a city as smart, such as economic development, environment, human capital, culture and leisure, and e-governance. Thus, the smartness concept is strictly linked to urban efficiency in a multifaceted way. A seminal research for European policy conducted by Giffinger et al. (2007) defines a smart city on the basis of several intangible indicators, such as a smart economy, smart mobility, smart environment, smart people, smart living, and smart governance. These authors’ …