Search results for "R2"
showing 10 items of 285 documents
Interpreting Heterogeneous Geospatial Data Using Semantic Web Technologies
2016
International audience; The paper presents work on implementation of semantic technologies within a geospatial environment to provide a common base for further semantic interpretation. The work adds on the current works in similar areas where priorities are more on spatial data integration. We assert that having a common unified semantic view on heterogeneous datasets provides a dimension that allows us to extend beyond conventional concepts of searchability, reusability, composability and interoperability of digital geospatial data. It provides contextual understanding on geodata that will enhance effective interpretations through possible reasoning capabilities. We highlight this through …
Simulations des écoulements dans le bassin versant du fleuve Mono (Afrique de l'ouest) avec le modèle GR2M.
2007
National audience; Dans le contexte de la péjoration pluviométrique observée depuis les années 1970 et le manque criard des données d'écoulements en Afrique de l'Ouest, l'évaluation des écoulements présente un intérêt particulier pour les scientifiques. La présente étude s'intéresse à la simulation des données hydrologiques dans le bassin du fleuve Mono. Le modèle choisit est le GR2M (modèle génie rural) à deux paramètres au pas de temps mensuel. C'est un modèle empirique qui permet la simulation appréciable des écoulements dans le bassin de 1965 à 1988. Les résultats de plusieurs auteurs confirment l'efficacité de ce modèle GR2M.
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3
2017
International audience; By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid. Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder frequently caused by non-assembly of dynein arm motors into cilia and flagella axonemes. Before their import into cilia and flagella, multi-subunit axonemal dynein arms are thought to be stabilized and pre-assembled in the cytoplasm through a DNAAF2DNAAF4- HSP90 complex akin to the HSP90 co-chaperone R2TP complex. Here, we demonstrate that large genomic deletions as well as point mutations involving PIH1D3 are…
Microglia and α-synuclein implication in Parkinson's disease
2011
Age-related neurodegenerative disorders like Parkinson’s disease take an enormous toll on individuals and on society. Despite extensive efforts, Parkinson’s disease remains incurable and only very limited treatments exist. Indeed, Parkinson’s pathogenesis is still not clear and research on its molecular mechanisms is ongoing. In this study, we focused our interest on two abnormal events occurring in Parkinson’s patients, namely α-synuclein aggregation and microglial activation. We first investigated α-synuclein and its abnormal polymerisation. For this purpose, we developed novel methods, which allowed the in vitro production of different types of α-synuclein oligomers. Using highly sensiti…
Astrometry and photometry of digitized plates of Baldone Schmidt telescope
2021
Abstract During the 40-year photographic period of astronomical observations, the Baldone Astrophysical Observatory has accumulated more than 22,000 direct and 2,500 spectral images. In 2018, the digitization of direct astrophoto images with a resolution of 1200 dpi was completed. A processing methodology for obtaining the equatorial coordinates and photometric characteristics of the objects recorded in digitized astronegatives using the LINUX/MIDAS/ROMAFOT environment has been developed at the Main Astronomical Observatory of the National Academy of Sciences of Ukraine. Program package with success already works in seven observatories. A description of the operation of this program complex…
Distinct bhaplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe
2015
Abstract: Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplo…
The experimental antiphospholipid syndrome: an invaluable tool to study autoimmunity-induced neurodegeneration
2014
cells and its activation inhibits their differentiation and remyelination. These suggest a possible role of CNS TLR2 in progressive autoimmune demyelination. Methods: We examined the effects of intra-cerebro-ventricular (ICV) injection of Zymozan, a TLR2 agonist, on the clinical and pathological course of EAE. The survival and clinical scores were monitored; demyelination and axonal loss were quantified by gold-black and Bielschowsky stains, and the nature of neuro-inflammatory response was characterized by TLR2, IBA-1 and CD3 stainings and PCR for immune cytokines. Immune cells were isolated from EAE brain tissue and their proliferative response to the autoantigen (PLP peptide) or Concaval…
Algebraic models of the real affine plane
2017
We introduce a new invariant, the real (logarithmic)-Kodaira dimension, that allows to distinguish smooth real algebraic surfaces up to birational diffeomorphism. As an application, we construct infinite families of smooth rational real algebraic surfaces with trivial homology groups, whose real loci are diffeomorphic to $\mathbb{R}^2$, but which are pairwise not birationally diffeomorphic. There are thus infinitely many non-trivial models of the real affine plane, contrary to the compact case.
Toll-like receptors play a crucial part in the pathophysiological activity of antiphospholipid antibodies
2011
The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis, recurrent fetal loss and the presence of a variety of antiphospholipid antibodies (aPL), directed to phospholipids like Cardiolipin and phospholipid binding proteins like β2-glycoprotein I. Till date, the pathophysiological processes underlying these thrombotic events were still not fully understood. Recent data support the idea that the aPL might act via enhanced cytokine release due to activation of certain Toll-like receptors. The investigation of some of those mechanisms in more detail enlightens the involvement of the intracellular receptors TLR7 and TLR8 in a central point. Using patients…
Natriuretic peptide system: physiology and clinical utility
2004
This review discusses the physiology of natriuretic peptides as a group and brain natriuretic peptide (BNP) in more detail. It will also highlight implications for the use of the natriuretic peptides in the diagnosis and treatment of patients with cardiovascular disease.The heart secretes two major natriuretic peptides: atrial natriuretic peptide (ANP), which is synthesized in the atrial myocardium, and BNP, which is synthesized in the ventricular myocardium. Both ANP and BNP are released in response to atrial and ventricular stretch, respectively, and will cause balanced vasodilation, natriuresis, and inhibition of the sympathetic nervous system and the renin-angiotensin-aldosterone axis. …