Search results for "RACE"

Green biotechnology for valorisation of residual biomasses in nutraceutic sector: Characterization and extraction of bioactive compounds from grape p…

2019

The grape pomace (GP) is an important by-product of winemaking, accounting for about 13-25% of the grapes processed. The aim of this work was to investigate the nutritional and antioxidant composition of GP obtained from Nero d’Avola (NA) grape, one of the most important indigenous varieties in Italy, in order to verify application in nutraceutics. Seeds and skin of the GP were studied for their nutritional and antioxidants composition, fatty acid and polyphenols profile, bioactives properties in vitro, by gravimetric, spectrophotometric and chromatographic techniques. The results showed that NAGP seeds are rich in the beneficial polyunsaturated fatty acids and that the polyphenols extracte…

Modulación de la vía Glu-NO-GMPc y del aprendizaje por GMPc extracelular en cerebelo. Mecanismos moleculares implicados. Alteraciones en modelos anim…

2014

En modelos animales de hiperamonemia y encefalopatía hepática (EH) está disminuida la capacidad de aprendizaje de un test de discriminación condicionada en el laberinto en Y. La infusión crónica intracerebral de GMPc mediante bombas osmóticas restaura la capacidad de aprendizaje en el laberinto en Y en ratas con hiperamonemia crónica. El mecanismo por el que el GMPc extracelular modula la capacidad de aprendizaje no se conoce. La vía glutamato (Glu)-óxido nítrico (NO)-GMPc modula el aprendizaje en el laberinto en Y. La función de esta vía está alterada en modelos animales de hiperamonemia y EH, conduciendo a una disminución de la capacidad de aprendizaje en el laberinto en Y. Puesto que la …

Performing arts and mediation technology in the period of lockdown

2021

Advancements in digital technologies have become novel ways to enrich communication, expression, and transmission of arts knowledge. Technology is increasingly implemented in the performance space, as a source of inspiration for artists. Especially in this period of lockdown, mediation technology has turned out to be an essential tool for different aspects of social life, as in performing arts. With venues, schools and artistic activities closed, performers, students and spectators have been obliged to keep connecting in remote conditions. This article wants to retrace the aesthetic impact of mediation technology in performing arts during this period of lockdown by focusing on the aspects t…

Potential roles of extracellular vesicles in brain cell-to-cell communication

Potential roles of extracellular vesicles in brain cell-to-cell communication Extracellular vesicles (EVs) are released into thè extracellular space from both cancer and normal brain cells, and are probably able to modify thè phenotypic properties of receiving cells1. EVs released from astrocytes and neurons contain FGF2 and VEGF2'3 and induce a 'blood-brain barrier' (BBB) phenotype in cultured brain capillary endothelial cells (BCECs, unpublished results), On thè other hand, EVs from G26/24 oligodendroglioma induce apoptosis in neurons and astrocytes4-5. These effects are probably due to Fas Ligand and TRAIL, present in G26/24 vesicles4-5. Moreover, G26/24 EVs contain extracellular matrix …

Asymmetric Synthesis of Chiral Bimetallic [Ag28Cu12(SR)24]4– Nanoclusters via Ion Pairing

2016

In this work, a facile ion-pairing strategy for asymmetric synthesis of optically active negatively charged chiral metal nanoparticles using chiral ammonium cations is demonstrated. A new thiolated chiral three-concentric-shell cluster, [Ag28Cu12(SR)24]4–, was first synthesized as a racemic mixture and characterized by single-crystal X-ray structure determination. Mass spectrometric measurements revealed relatively strong ion-pairing interactions between the anionic nanocluster and ammonium cations. Inspired by this observation, the as-prepared racemic mixture was separated into enantiomers by employing chiral quaternary ammonium salts as chiral resolution agents. Subsequently, direct asymm…

Major ions and trace elements composition of rainwater around the two industrial areas of Milazzo and Priolo Gargallo (Sicily - Italy)

2023

This database shows the concentration of major ions and trace elements in rainwater from two polluted industrial areas of Sicily, Milazzo and Priolo Gargallo, collected from June 2018 to July 2019, through a network of 11 bulk collectors to sample bulk atmospheric deposition, for a total of 131 samples collected. Different sources, both natural and anthropogenic, for both major ions and trace elements have been recognised. This study also highlighted some critical issues with common methods of sampling and analysing atmospheric deposition. The analysis and comparison of two different aliquots, filtered and unfiltered rainwater, has shown that the filtration method removes from the sample a …

Chemistry of atmospheric depositions over two polluted industrial areas of Sicily (Italy)

2021

Dry and wet depositions provide the pathways through which particles and gases emitted into the atmosphere return to the Earth’s surface. Bulk deposition is defined as the sum of dry and wet deposition, which is characterized by water-soluble and insoluble chemical species. Recent studies (e.g. Castillo et al., 2017) showed that most of the atmospheric deposition in Europe occurs in the wet form, but in southern European regions the role of dry contribution can be as significant as that of wet deposition. In the framework of the multidisciplinary project “CISAS” (Centro Internazionale di Studi Avanzati su Ambiente, ecosistema e Salute umana), bulk depositions were monthly sampled over two p…

Mount Etna volcanic emissions signature on the chemical composition of bulk atmospheric deposition in Sicily, Italy.

2022

Mt. Etna, on the eastern coast of Sicily (Italy), is one of the most active and most intensely monitored volcanoes on the Earth, widely recognized as a big source of volcanic gases, such as CO2, SO2, halogens, and many trace elements, including technological critical elements (TCEs), to the atmosphere on a regional and global scale. Mt. Etna emissions account for a significant percentage of the worldwide average volcanic budget and especially during eruptive periods, its products can be dispersed over great distances and they influence the chemical composition of the atmosphere of other continents too. The current knowledge about the geochemical cycle of TCEs is still scarce, nevertheless, …

Glutathione in Cancer Cell Death

2011

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death. The intracellular thiol redox state (controlled by GSH) is one of the endogenous effectors involved in regulating the mitochondrial permeability transition pore complex and, in consequence, thiol oxidation can be a causal factor in the mitochondrion-based mechanism that leads to cell death. Nevertheless GSH depletion is a common feature not only of apoptosis but also of other types of cell death. Indeed rates of GSH synthesis and…

Omega-3 Extraction from Anchovy Fillet Leftovers with Limonene: Chemical, Economic, and Technical Aspects

2019

International audience; We investigate selected chemical, technical, and economic aspects of the production of fish oil rich in polyunsaturated omega-3 fatty acids from anchovy filleting leftovers using d-limonene as the extraction solvent at ambient temperature and pressure. Entirely derived from the orange peel prior to orange squeezing for juice production, the bio-based solvent is easily recovered, affording a circular economy process with significant potential for practical applications.