Search results for "RACE"
showing 10 items of 4458 documents
PET Imaging of the Impact of Extracellular pH and MAP Kinases on the p-Glycoprotein (Pgp) Activity
2012
The functional activity of p-glycoprotein (Pgp) can be increased in vitro by an extracellular acidosis via activation of MAP kinases (p38, ERK1/2). In order to study these effects in vivo a new (68)Ga-labeled PET tracer was developed which serves as a substrate of the Pgp and therefore indirectly mirrors the Pgp activity. For in vivo studies, experimental tumors were imaged under acidic conditions (inspiratory hypoxia, injection of lactic acid) and during inhibition of MAP kinases in a μ-PET system. In vitro, [(68)Ga]MFL6.MZ showed an accumulation within the cells of about 20% which was increased to 30% by Pgp inhibition. In solid tumors a marked tracer uptake was observed showing spatial h…
Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
2019
In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…
Modeling of intracellular transport in realistic cell geometries
2018
The transport of molecules inside cells is a complex process, the characterization of which is important to gain full understanding of cellular processes. Understanding of intracellular transport is also important for medical applications, for example when analyzing transport of medicine inside cells. The intracellular environment is very complex, and at least the most crucial parts of this complexity must be accounted for to solve transport problems in cells. In this thesis the results of studies in modeling intracellular transport are presented. The aim of the work was to model intracellular transport of proteins and viral capsids in realistic cell environments. To this end, microscopic m…
Spaghetti Enriched with Inulin: Effect of Polymerization Degree on Quality Traits and α-Amylase Inhibition.
2022
Inulin is considered a dietary fiber and represents a noteworthy ingredient for food biofortification due to its health effects and its neutral taste. The aim of the work was the evaluation of the quality of pasta produced using whole-meal flours of two ancient Sicilian landraces (Senatore Cappelli-CAP and Timilia—TIM) fortified with two types of inulin (long-chain topinambur inulin IT and low-chain chicory inulin IC), at two different levels of substitution (2 and 4%) to evaluate its possible effect on α-amylase inhibition. The color indices L* and a* were mainly influenced by cultivars, while IT improved the sensory attributes, mainly the elasticity sensation, and influenced l…
The transformation of the Horatian Sabine farm in Persius? Satire 6
2020
The purpose of this article is to focus on the motif of the countryside in Roman satire. In particular, it aspires to study the way the Sabine farm is delineated in Horace's Satire 2.6 and later in his Epistles, in order to elucidate the evolution of this motif in Persius? 6th Satire. In this poem, Persius addresses Caesius Bassus, who retreats to Sabine to seek poetic inspiration, but seems trapped in the paths of earlier poetry and cannot attain bliss, while the poet achieves it in the port of Luna.
Effets de quartier, effet de département : discrimination liée au lieu de résidence et accès à l'emploi
2013
L’objet de cette étude est de mesurer la discrimination à l’embauche à l’encontre des jeunes en Ile-de-France en raison du lieu de résidence en considérant plusieurs échelles spatiales de façon à distinguer l’effet de la réputation du département (Paris et la Seine-Saint-Denis), celui de la localité et celui du quartier. L’évaluation est réalisée sur données expérimentales auto-construites de testing selon un protocole permettant d’examiner les effets propres à chacune de ces trois échelles sur l’accès à l’emploi ainsi que leurs effets cumulés. On s’intéresse aux discriminations pour deux professions en tension du secteur de la restauration pour laquelle les discriminations devraient a prio…
Trace eyeblink conditioning and extinction contingent to hippocampal ripples in rabbits
2014
Geochemical characterization of water quality in karst systems of Greece
2021
Karst systems represent the main drinking water source for 20-25% of world’s population, although covering only 7-10% of the global land surface (Ford & Williams, 2007). Karst aquifers are highly vulnerable to external pollution, so their protection and management is of critical importance to sustain water resources. In Greece, starting from the 1970’s, water demands for agricultural, domestic and industrial use increased significantly, mainly in coastal areas (Daskalaki & Voudouris, 2008). The main Hellenic aquifers are hosted in alluvial deposits, in Neogene deposits and in carbonate rocks. The latter cover about 35% of the country and are located in Western, Central and Southern …
Race et espace : la ville comme lieu d’étude des représentations raciales
2022
Cette étude examine les « paysages raciaux » dans le centre-ville de Bordeaux, c'est-à-dire la façon dont les discours sur la race et le racisme se matérialisent au quotidien. Les paysages raciaux rendent compte de la nature contradictoire des discours sur la race et le racisme en Europe, et en France, qui sont à la fois omniprésents et dissimulés. Analyser le centre-ville de Bordeaux permet d’appréhender la manière dont les discours locaux et nationaux s’étayent et se construisent, mettant ainsi en lumière les relations complexes entre les discours sur la race, le passé colonial et le cadre républicain universaliste spécifique à la France (Fila-Bakabadio 2011). Cette étude pose donc la que…
Otrējo spirtu dinamiskā kinētiskā sadalīšana
2019
Antrinių alkoholių dinaminė kinetinė rezoliucija. Simonas Balkaitis. Darbo vadovas: Dr. chem. Artis Kinēns. Magistrinį darbą sudaro 63 puslapiai, 10 iliustracijų, 31 schema, 14 lentelių, 1 lygtis, 53 literatūros šaltiniai. Darbas parašytas anglų kalba. Pirmiausia buvo ištirta antrinių alkoholių racemizacija įvairių iridžio, rutenio ir geležies katalizatorių pagalba. Tuomet, racemizacijai tinkamiausiuose tirpiklių variantuose buvo tiriama alkoholių kinetinė rezoliucija. Gauti duomenys buvo panaudoti naujos dinaminės kinetinės rezoliucijos procedūros paieškose.