Search results for "RAIL"
showing 10 items of 699 documents
Numerical Analysis of a Transposed Multiwired Armature in Electromagnetic Rail Launchers
2020
Solid armatures in electromagnetic rail launchers have to undergo severe electromagnetic, mechanical, and thermal stresses. These stresses are unevenly distributed in the armature mainly due to the velocity skin effect. Contrasting this effect reduces the peak to average ratio of the stresses and allows better performance of the device. In this article, the behavior of a transposed multiconductor solid armature is numerically investigated by the research code electric network for electromagnetics (EN4EM) developed at the Department of Energy, System, Territory and Construction Engineering (DESTEC), University of Pisa, Pisa, Italy. The code is based on an integral formulation that reduces th…
Identification of Bending Modes of Vibration in Rails by a Laser Doppler Vibrometer on a Moving Platform
2020
This paper introduces a method to identify the bending modes of vibration of railway tracks by using a laser Doppler vibrometer (LDV) mounted on a moving platform. Two sets of experiments were conducted at Transportation Technology Center Inc. (TTCI) in Pueblo Colorado, in order to validate the proposed method. First, the bending vibration modes were identified using the signals collected from a rail span (rail section between two consecutive sleepers) by accelerometers under moving car excitation. Then, vibration measurements from rail spans were obtained by using an LDV mounted on the moving railcar. All tests were carried out at four different rail car speeds: 8 km/h (5 mph), 16 km/h (10…
BEM Formulation of the Trailing Edge Condition
1995
This paper deals with a BEM formulation of the trailing edge condition to determine the potential flow field around an airfoil. It is seen the trailing edge condition is not sufficient to give an unique solution. It is necessary to assign a further condition to eliminate the nonuniqueness of the solution. The approach allows to adopt a discretization into superior order elements. Some preliminary applications show the validity of the formulation.
Swimrun: An emerging new endurance sport
2018
International audience; The swimrun is a new endurance team-sport based on two persons swimming and running alternatively through open water and mostly trails. The aim of this study was to analyse participation and performance trends for males, females and mixed duo team at the ÖTILLÖ Swimrun race (10 km open-water swimming and 65 km trail running). During the 2012–2016 period, the mean total time performance of the best athletes at the ÖTILLÖ Swimrun decreased significantly by 17 min/year for males, 40 min/year for mixed and 59 min/year for females duo, respectively. The difference in performance between the best males and females duo (26 ± 15%) was significantly greater compared to the di…
Mécanismes de résistance à l'apoptose induite par TRAIL dans les cellules cancéreuses : restauration de la sensibiltié à TRAIL par la chimiothérapie …
2010
The TNF-family member TRAIL (TNF-related apoptosis inducing ligand) is a cytokine involved in immune anti-tumour surveillance. TRAIL is one of the most promising agents currently under investigation, as it exhibits efficient anti-cancer cytotoxicity with limited side effects on healthy cells. The problem in current cancer therapy is that some cancer cells are already resistant, or can become resistant to TRAIL-induced cell death. The aim of my thesis was to study the mechanisms of resistance to TRAIL, and to find a way to bypass it. First, we were interested in the TRAIL-R4 antagonistic receptor, which is known to bind TRAIL without inducing a death signal. We have demonstrated for the firs…
Editor's Choice - Frailty and the management of patients with acute cardiovascular disease:A position paper from the Acute Cardiovascular Care Associ…
2018
Frailty is increasingly seen among patients with acute cardiovascular disease. A combination of an ageing population, improved disease survival, treatable long-term conditions as well as a greater recognition of the syndrome has accelerated the prevalence of frailty in the modern world. Yet, this has not been matched by an expansion of research. National and international bodies have identified acute cardiovascular disease in the frail as a priority area for care and an entity that requires careful clinical decisions, but there remains a paucity of guidance on treatment efficacy and safety, and how to manage this complex group. This position paper from the Acute Cardiovascular Care Associa…
Zinātnes pētījumu tiešsaistes bibliotēka
2016
Kvalifikācijas darbs apraksta zinātnes pētījumu tiešsaistes bibliotēkas sistēmas minimālo produktu. Sistēmas uzdevums ir ļaut lietotājiem interesēties par dažādām zinātnes jomām, un lasīt jaunākos pētījumus izvēlētajās zinātnes jomās. Apspriest rakstus ar komentāru palīdzību. Veidot savus rakstu sarakstus, lai būtu vieglāk tos atrast nāktone. Mājaslapa balstās uz lietotāju aktivitāti un uz viņu uzņēmību pievienot rakstus un papildināt vienam otru. Mājaslapa taisīta izmantojot Ruby valodas ietvaru Ruby on Rails un PostgreSQL datubāzi.
A methodological approach to analyze the territorial appropriation of high-speed rail from interactions between actions and representations of local …
2019
International audience; Because it is difficult to separate the specific transport impact from other factors influencing economic and spatial development, the focus in research is increasingly on understanding the process by which territorial changes occur in order to explain how economic and social agents and local authorities have appropriated new transportation systems. This appropriation plays a crucial part in territorial dynamics. The diversity of economic and spatial changes produced by high-speed rail indicates the existence of multiple modes of appropriation which vary according to the location of stations, the mobilization of local stakeholders confronted with the transport operat…
FKBP51 Affects TNF-Related Apoptosis Inducing Ligand Response in Melanoma
2021
Melanoma is one of the most immunogenic tumors and has the highest potential to elicit specific adaptive antitumor immune responses. Immune cells induce apoptosis of cancer cells either by soluble factors or by triggering cell-death pathways. Melanoma cells exploit multiple mechanisms to escape immune system tumoricidal control. FKBP51 is a relevant pro-oncogenic factor of melanoma cells supporting NF-κB-mediated resistance and cancer stemness/invasion epigenetic programs. Herein, we show that FKBP51-silencing increases TNF-related apoptosis-inducing ligand (TRAIL)-R2 (DR5) expression and sensitizes melanoma cells to TRAIL-induced apoptosis. Consistent with the general increase in histone d…
Apoptosis: a relevant tool for anticancer therapy.
2006
Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Defective apoptosis represents a major causative factor in the development and progression of cancer. The majority of chemotherapeutic agents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standard chemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells. Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis to treat cancer. These new target include those acting in the ext…