Search results for "RAM"

showing 10 items of 35643 documents

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

2015

ABSTRACT Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apopto…

lcsh:MedicineMedicine (miscellaneous)Genes InsectApoptosisDystrophyInhibitor of Apoptosis ProteinsAnimals Genetically ModifiedCTG repeat expansion0302 clinical medicineImmunology and Microbiology (miscellaneous)Drosophila ProteinsMyotonic DystrophyMyocyte0303 health sciencesTOR Serine-Threonine KinasesMyotonin-protein kinaseNuclear ProteinsMuscle atrophyUp-RegulationCell biologyMuscular AtrophyDrosophila melanogastermedicine.anatomical_structureFemalemedicine.symptomSignal TransductionResearch Articlelcsh:RB1-214congenital hereditary and neonatal diseases and abnormalitiesProgrammed cell deathNeuroscience (miscellaneous)BiologyMyotonic dystrophyMyotonin-Protein KinaseMuscleblindGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesAutophagylcsh:PathologymedicineAnimalsHumans030304 developmental biologylcsh:RAutophagyDystrophySkeletal musclemedicine.diseaseMolecular biologyDisease Models AnimalMuscle atrophyTrinucleotide Repeat Expansion030217 neurology & neurosurgeryDisease Models & Mechanisms
researchProduct

Cytocompatibility and Bioactive Properties of Hydraulic Calcium Silicate-Based Cements (HCSCs) on Stem Cells from Human Exfoliated Deciduous Teeth (S…

2020

The implementation of hydraulic calcium silicate-based endodontic cements (HCSCs) in biologically based endodontic procedures for the primary dentition has been recently investigated, focusing on the biological response of stem cells from human exfoliated deciduous teeth (SHEDs) towards them. The present systematic review aimed to present a qualitative synthesis of the available literature consisting of in vitro assays, which assessed the cytocompatibility and bioactive properties of HCSCs in direct contact with SHEDs. Following the PRISMA statement, an electronic database search was carried out in Medline, Scopus, Embase, Web of Science, and SciELO on March 31st and updated on November 16t…

lcsh:MedicineReview03 medical and health scienceschemistry.chemical_compound0302 clinical medicinecalcium silicate cementsDeciduous teethMedicinedental stem cellsViability assayProroot mtacell viability030304 developmental biology0303 health sciencesbusiness.industrylcsh:RIn vitro toxicology030206 dentistryGeneral MedicineIn vitromedicine.anatomical_structurechemistrybioceramicbioactivityCalcium silicateCancer researchStem cellNodule formationbusinessJournal of Clinical Medicine
researchProduct

Performing sound of the past: Remix in electronic dance music culture

2014

The term remix, defined as an activity of taking data from pre-existing materials to combine them into new forms according to personal taste, relates to various elements and areas of contemporary culture. Whichever model used, consideration of the remix depends on recognition of pre-existing cultural codes. Therefore, as a second layer, the remix relies on the authority of the original and it functions at the meta-level. The audience may see a trace of history with the pre-existing object and the meaning creates in the viewer(s), reader(s), listener(s) or, in the contemporary world of DJs and popular electronic dance music culture - in dancer(s). With the aim of specifying modes of creating…

lcsh:Musical instruction and studygeographygeography.geographical_feature_categoryremixclubbing ambientmedia_common.quotation_subjectGeneral MedicineArtElectronic dance musicVisual artsperforming audienceGramophonedziePerformance artpre-existing materiallcsh:MT1-960Sound (geography)media_commonMuzikologija
researchProduct

‘bien entendu’ vs ‘naturellement’: deux façons de désubjectiviser le dire

2011

Our study focuses on how the discourse markers (DM) participate in the construction of discursive alterity. In our approach, the DM builds, for an assertion, a guarantor with its own semantics, which is the semantics of the lexical element constituting the basis of DM. Naturellement and bien entendu build referential value which ”disempowers” the speaker as a guarantor of his words. This desubjectivation is realized differently in each case analyzed, and is determined by the semantic identity of the DM. In this article we analyze how the DM build modulated commitment of the speaker in his role as the guarantor, convened by the semantics of the DM in the ”disresponsibilization” of the speake…

lcsh:P101-410AlterityAssertionIdentity (social science)SociologySemanticsValue (semiotics)HumanitiesDiscourse markerLinguisticslcsh:Language. Linguistic theory. Comparative grammarOslo Studies in Language
researchProduct

Strategie autofinzionali in "Leggenda privata" di Michele Mari

2019

Leggenda privata (2017) is the latest in a series of autobiographical writings by Michele Mari. The novel is the factual narration of the author's childhood and adolescence, documented by family photos, but is also the narration of a fictional and fantastic situation of writing, where the reader is involved in live recording. In particular, the narrative framework is structured almost like a personal essay that engages dialogically the norms and potentials, opportunities and risks of a theory of autobiography. The purpose of this article is to explore the limits, the difficulties, indeed the impossibility of autobiographical writing in Leggenda Privata, which instead verges towards a comple…

lcsh:P101-410OnomasticSettore L-FIL-LET/14 - Critica Letteraria E Letterature Comparatelcsh:Translating and interpretinglcsh:Geography. Anthropology. Recreationlcsh:P306-310Michele Marilcsh:Language. Linguistic theory. Comparative grammarAutofictionlcsh:Gcornice narrativaMichele Mari; autofiction; autobiografia; onomastica; cornice narrativaNarrative ThresholdAutobiografiaAutobiographyonomastica
researchProduct

The afterworld space in the "Poem strip" (1969) by Dino Buzzati

2018

L’obiettivo del contributo è l’analisi dello spazio oltremondano in Poema a fumetti(1969) di Dino Buzzati, graphic novelante-litteram. Buzzati riscrive, in chiave ultramoderna e laica, sia il mito di Orfeo ed Euridice, restituendo la centralità alla potenza della musica, sia il mito della discesa agli inferi, toposassoluto della letteratura italiana a partire da Dante e rappresentazione allegorica dell’oltretomba cristiano. In particolare Buzzati inventa una rappresentazione visiva dello spazio dell’aldilà dove sono essenziali due elementi: la continuità/discontinuità dei due mondi, nominalmente diversi, e le cornici che permettono il passaggio da un mondo all’altro. Il motivo ricorrente di…

lcsh:P101-410lcsh:Translating and interpretinglcsh:Geography. Anthropology. RecreationDescent into hellPoema a fumettiDino Buzzati; Poem strip; Discesa agli Inferi; Orfeolcsh:P306-310Discesa agli Inferilcsh:Language. Linguistic theory. Comparative grammarDino Buzzativiaggio agli inferilcsh:GDino Buzzati; Poema a fumetti; viaggio agli inferi; OrfeoDino Buzzati; Poema a fumetti; Descent into hell; OrpheusPoem stripOrfeoDino Buzzati; Poem strip; Descent into hell; OrpheusOrpheusBetween
researchProduct

Nye litteraturer: Litterære tekstpraksiser hos voksne innvandrere i norsk grunnskoleopplæring

2020

Voksne innvandrere som tar norsk grunnskoleeksamen har teksterfaringer fra litteraere tradisjoner som kan vaere ukjente i var sammenheng. Basert pa naermere tyve enkeltintervjuer undersoker denne studien bade tidligere og navaerende litteraere tekstpraksiser hos informanter fra Syria, Eritrea og Somalia. Ett av studiens funn er at enkelte informanter med svaert lite skolegang likevel har aktive litteraere tekstpraksiser. Imidlertid vil de fleste litteraere tekstpraksisene sannsynligvis ikke bli gjenkjent i skolesammenheng, ettersom de opptrer utenfor skolens domene og bare unntaksvis er knyttet til trykte, papirbaserte tekster, som boker. I stedet er youtube det mest brukte mediet. Studien …

lcsh:P101-410media_common.quotation_subjectskjult literacyNorwegianlanguage.human_languageLiteracymigrasjonlitterære tekstpraksisers funksjonerlcsh:Education (General)lcsh:Language. Linguistic theory. Comparative grammarVDP::Humaniora: 000::Språkvitenskapelige fag: 010::Nordiske språk: 018Formal educationlitterært repertoarPolitical scienceEthnographylanguageovergang mellom praksiserlitteraturdidaktikkReligious studieslcsh:L7-991media_commonNordic Journal of Literacy Research
researchProduct

Per una bibliografia giraldiana commentata

2018

Si presenta l’intera bibliografia giraldiana aggiornata. We offer here the new entire bibliography of Giraldi, completed and up to date.

lcsh:PN1600-3307lcsh:DramaItalià
researchProduct

Prefazione

2019

----

lcsh:PN1600-3307lcsh:DramaItalià
researchProduct

Analytical Research Based on the Use of Low Cost Instrumentation

2019

lcsh:Pharmacy and materia medicaLow Cost InstrumentationComputer scienceAnalytical ResearchResearch basedSystems engineeringlcsh:RS1-441Pharmaceutical ScienceInstrumentation (computer programming)General Pharmacology Toxicology and PharmaceuticsGreen Analytical ChemistryPharmaceutical Sciences
researchProduct