Search results for "RAM"
showing 10 items of 35643 documents
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Celecoxib (Celebrex®) is a selective cyclooxygenase-2 (COX-2) inhibitor which exhibits antitumor effects in human HCC cells. The present study examined the interaction between celecoxib and sorafenib in two human liver tumor cell lines HepG2 and Huh7. Our data showed that each inhibitor alone reduced cell growth and the combination of celecoxib with sorafenib synergistically inhibited cell growth an…
The effect of dietary phosphorus deficiency on the immune responses of European whitefish (Coregonus lavaretus L.)
2003
Low phosphorous (P) feeds in aquaculture are recommended to reduce eutrophication of water systems. However, the feed should be adequate for normal growth and intact immune defence. Influence of low dietary P supply on non-specific and specific immune defence of European whitefish (Coregonus lavaretus) was studied in two trials. For Trial 1, a semi-purified, low-P diet was formulated and supplied with 0, 2.5, 5.0, 7.5, or 10.0 g P kg(-1)to obtain a P gradient of 4.4-14.9 g kg(-1)diet. Diets were fed to four replicate groups of fingerling whitefish for 42 days in a flow-through, freshwater system maintained at 15 degrees C. Fish fed with the P-unsupplemented diet had significantly lower plas…
Immune Modulating Effects of NKT Cells in a Physiologically Low Dose Leishmania major Infection Model after αGalCer Analog PBS57 Stimulation
2014
Leishmaniasis is a parasitic infection affecting ∼12 million people worldwide, mostly in developing countries. Treatment options are limited and no effective vaccines exist to date. Natural Killer T (NKT) cells are a conserved innate-like lymphocyte population with immunomodulating effects in various settings. A number of reports state a role of NKT cells in different models of Leishmania infection. Here, we investigated the effect of NKT cells in a physiologically relevant, intradermal low dose infection model. After inoculation of 103 infectious-stage L. major, comparable numbers of skin-immigrating NKT cells in both susceptible BALB/c mice and resistant C57BL/6 mice were noted. Compared …
Kinetic properties of catecholoxidase activity of tarantula hemocyanin
2008
Phenoloxidases occur in almost all organisms, being essentially involved in various processes such as the immune response, wound healing, pigmentation and sclerotization in arthropods. Many hemocyanins are also capable of phenoloxidase activity after activation. Notably, in chelicerates, a phenoloxidase has not been identified in the hemolymph, and thus hemocyanin is assumed to be the physiological phenoloxidase in these animals. Although phenoloxidase activity has been shown for hemocyanin from several chelicerate species, a characterization of the enzymatic properties is still lacking. In this article, the enzymatic properties of activated hemocyanin from the tarantula Eurypelma californi…
Perfluoroalkylated amphiphilic MUC1 glycopeptide antigens as tools for cancer immunotherapy.
2010
The synthesis of perfluoroalkylated glycopeptide antigens and their specific binding to anti-MUC1 mouse antibodies is reported.
A Unified Theory of Psychophysical Laws in Auditory Intensity Perception.
2020
Psychophysical laws quantitatively relate perceptual magnitude to stimulus intensity. While most people have accepted Stevens's power function as the psychophysical law, few believe in Fechner's original idea using just-noticeable-differences (jnd) as a constant perceptual unit to educe psychophysical laws. Here I present a unified theory in hearing, starting with a general form of Zwislocki's loudness function (1965) to derive a general form of Brentano's law. I will arrive at a general form of the loudness-jnd relationship that unifies previous loudness-jnd theories. Specifically, the "slope," "proportional-jnd," and "equal-loudness, equal-jnd" theories, are three additive terms in the ne…
The Effect of 16-Minute Thermal Stress and 2-Minute Cold Water Immersion on the Physiological Parameters of Young Sedentary Men
2020
This study aimed to determine the effect of 16 minutes of thermal stress followed by 2 minutes of cold water immersion on the physiological parameters of fifty-five sedentary men (mean age 20.15±1.30 years), who were exposed to 16 minutes of sauna (temperature: 90-91℃; relative humidity: 14-16%) followed by 2 minutes of cold water immersion (12℃). The participants' somatic characteristics were determined before entering the sauna, and their body mass and blood pressure were measured before and after sauna treatment. Physiological parameters were monitored during the 16-minute sauna session and the 2-minute cold water immersion (CRIO) or shower. The subjects perspired 0.21-0.27 litres during…
Contexto-A: Programa de intervención en violencia de género en jóvenes con medidas judiciales
2017
Resumen Tesis Doctoral: Contexto-A: Programa de intervención en violencia de género en jóvenes con medidas judiciales M. Victoria Lorenzo López INTRODUCCIÓN La violencia contra la pareja en las relaciones de jóvenes y adolescentes o dating violence, ha sido definida por varios autores como todo acto o ataque intencional de tipo físico, psicológico o sexual de un miembro de la pareja contra el otro, en una relación romántica en la que no existe vínculo legal ni cohabitación (Póo y Vizcarra, 2011; Rubio-Garay, López-González, Saúl y Sánchez-Elvira-Paniagua, 2012). Aunque comparte elementos comunes con la violencia ejercida en las relaciones adultas, requiere de intervención y tratamiento espe…
Livelli di rappresentazione del testo nell’edizione del De nomine di Orso Beneventano
2018
Viene presentato l’impianto metodologico e tecnologico dell’edizione critica digitale del De nominedi Orso Beneventano (http://www.unipa.it/paolo.monella/ursus), una proof of concept delle innovazioni metodologiche proposte da Tito Orlandi. Il modello qui sperimentato intende superare la dicotomia tra edizione diplomatica e critica grazie ad un ripensamento profondo, semioticamente fondato, dei livelli di trascrizione e di edizione di un testo. I livelli scelti per questa edizione sono: (1) Livello grafematico, le cui unità minime sono i grafemi, inclusi i segni paragrafematici e le brachilogie sistematiche. Tutti i grafemi individuati dall’editore sono elencati nella Graphemic Table of Sig…
Izrādes pusaudžiem: problēmas un risinājumi (2017-2020)
2020
Maģistra darba “Izrādes pusaudžiem: problēmas un risinājumi” (2017-2020) mērķis ir noskaidrot, kāds ir Latvijas teātru piedāvājums pusaudžiem, vai tas atbilst auditorijas pieprasījumam un kāda ir teātru līdzšinējā politika, veidojot izrādes pusaudžiem. Lai to atklātu, darbā ir analizētas 25 izrādes pusaudžiem, kas iestudētas pēdējo trīs teātra sezonu laikā. Savukārt lai izpētītu pusaudžu domas par sev mērķētām izrādēm un noskaidrotu teātru praksi, iestudējot izrādes šai mērķauditorijai, tika veiktas fokusgrupu intervijas ar pusaudžiem un intervijas ar trīs teātru vadītājiem Pētījuma gaitā secināts, ka pusaudžiem veidotais piedāvājums pēdējos gados Latvijas teātros ir audzis, ko palīdzēja va…