Search results for "RANKL"
showing 10 items of 46 documents
New molecular targets in bone metastases.
2010
Bone metastases have a major impact on morbidity and on mortality in cancer patients. Despite its clinical relevance, metastasis remains the most poorly elucidated aspect of carcinogenesis. The biological mechanisms leading to bone metastasis establishment have been referred as " vicious circle," a complex network between cancer cells and the bone microenvironment. This review is aimed to underline the new molecular targets in bone metastases management other than bisphosphonates. Different pathways or molecules such as RANK/RANKL/OPG, cathepsin K, endothelin-1, Wnt/DKK1, Src have recently emerged as potential targets and nowadays preclinical and clinical trials are underway. The results fr…
The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases
2021
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), β3-integrin, or RANKL, toll-like receptors and growth factor receptors. Among the receptor-coupled signal transducers are extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinas…
Maailman ensimmäinen nainen - Eleanor Rooseveltin roolin ja kirjoitusten poliittisuus My Day - kolumneissa 1936-1941
2013
1930-luvun taitteessa puhjennut maailmanlaajuinen lama koetteli erityisen ankarasti Yhdysvaltoja ja leimasi maan kehitystä toisen maailmansodan puhkeamiseen asti. Franklin Roosevelt toimi maan presidenttinä vuosina 1933–1945 ja pyrki parantamaan ihmisten elinoloja sosiaalipoliittisella New Deal - ohjelmallaan. Hänen rinnallaan julkisuudessa ja myös poliittisen vaikuttamisen kulisseissa toimi hänen vaimonsa Eleanor Roosevelt, joka uudisti maan ensimmäisen naisen roolia aktiivisuudellaan. Tässä tutkielmassa tarkastellaan Eleanor Rooseveltin poliittista vaikutusvaltaa vuosina 1936–1941 hänen kirjoittamansa My Day – kolumnin kautta. Kolumnisteilla oli 1930-luvulla merkittävä rooli yhdysvaltalai…
The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineeri…
2013
Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likewise challenging to develop bone substitution materials to heal bone defects. During the differentiation of osteoblasts from their mesenchymal progenitor/stem cells and of osteoclasts from their hemopoietic precursor cells, a lineage-specific release of growth factors and a trans-lineage homeostatic cross-talk via signaling molecules take place. Hence, the major hurdle is to fab…
Artropodi dannosi nel florovivaismo siciliano
2006
Role of OPG-RANK-RANKL pathway in the pathophysiology, diagnosis and therapeutic follow-up of metastatic bone disease.
2011
IL RANK LIGANDO QUALE TARGET TERAPEUTICO NEL TRATTAMENTO DELLE PAZIENTI ANZIANE CON OSTEOPOROSI
2013
Cortical and trabecular bone undergo a continuous and balanced remodeling process, which consists of a phase of resorption, mediated by osteoclasts, and a phase of neoformation mediated by osteoblasts. The activity of both, osteoblasts and osteoclasts, is regulated by the osteocytes, which are the most abundant cells in bone tissue. An imbalance of this process with an excessive resorption activity causes a loss of bone mass and microarchitectural deterioration of the skeleton, with consequent reduction of bone strength and increased risk of fractures. The ligand for the “Receptor Activator of Nuclear Factor Kappa- B” (RANK-L), a protein expressed by osteoblasts, plays a fundamental role in…
Demo 167. Destilación por enfriamiento con un frasco de Franklin vertical
2021
Se presenta una demostración de aula que muestra que las fases líquida y vapor de una disolución que coexisten en equilibrio tienen distinta composición. Se muestra también que el disolvente y el soluto de una disolución en un frasco de Franklin vertical se pueden separar mediante destilación, concretamente condensando la fase vapor. A classroom demonstration is presented showing that the liquid and vapor phases of a solution that coexist in equilibrium have different composition. It is also shown that the solvent and solute of the solution in a vertical Franklin flask can be separated by distillation, specifically by condensing the vapor phase.
Demo 168. Demostración de la ley de Raoult y de la nucleación heterogénea con un frasco de Franklin vertical
2021
Se presenta una demostración de aula que muestra que la condensación del vapor se produce preferentemente sobre la superficie de partículas sólidas y que la presión de vapor de una disolución disminuye cuando aumenta la concentración de soluto. A classroom demonstration is presented showing that vapor condensation occurs preferentially on the surface of solid particles and that the vapor pressure of a solution decreases as the solute concentration increases.
Ética profesional y Logoeducación. El abogado de familia desde la filosofía de Viktor E. Frankl
2015
La reflexión sobre la labor del abogado de familia entendemos que hasta ahora se ha centrado más en cuestiones deontológicas que éticas, más en cuestiones estrictamente jurídicas que existenciales. Procediendo así se puede incurrir en un cierto reduccionismo. Frente a ello, somos conscientes de que su ética profesional ─en cuanto ética aplicada─ implica un diálogo interdisciplinar en el que deben participar no sólo los expertos en el ámbito jurídico sino también los especialistas de otros campos, así como los afectados que también deben expresar sus intereses. Desde este punto de vista interdisciplinar, el pensamiento del psiquiatra Viktor E. Frankl puede ser una valiosa aportación al citad…