Search results for "RATES"

Debating Sound Money in Early Modern Europe: From Dualist to Metallic Monetary Systems

2019

International audience; In this paper, we present the monetary debates in Europe from the XVIth to the XVIIIth centuries from the viewpoint of the problem of good and sound money. The framework of the paper is built on a typology of monetary systems, by which a dualist system is distinguished from a metallic one. Under the dualist system, the value in units of account of the specie in circulation was defined by monetary proclamations (Einaudi locates this era from Charlemagne to the French Revolution). Metallist proponents aimed at preventing any kind of manipulations with a radical transformation of the system of payment, which gave birth to a metallic monetary system from the very end of …

Characterization of Membrane-Bound Cyclic Nucleotide Phosphodiesterases from Bovine Aortic Smooth Muscle

1992

This study reports the isolation and characterization of cyclic nucleotide phosphodiesterases (PDEs) associated with membrane fraction in comparison to cytosolic forms from bovine aorta. DEAE-Sephacel chromatography of a solubilized membrane fraction from a homogenate, prepared under isotonic conditions in the presence of protease inhibitors, yielded one major peak of PDE activity that specifically hydrolyzed cAMP and was not stimulated by calmodulin: It appeared to contain two subtypes of PDE. The first subtype belonged to the cyclic GMP (cGMP)-inhibited PDE family, (PDE III): It had an apparent Km value of 0.4 microM and was potently inhibited by cGMP, LY186126, and cilostamide. The secon…

Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress

2015

Abstract Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator effects improving symptoms in patients with acute and chronic congestive heart failure, stable coronary artery disease, acute coronary syndromes, or arterial hypertension. The mechanisms underlying vasodilation include the release of •NO or a related compound in response to intracellular bioactivation (for GTN, the mitochondrial aldehyde dehydrogenase [ALDH-2]) and activation of the enzyme, soluble guanylyl cyclase. Increasing cyclic guanosine-3′,-5′-monophosphate (cGMP) levels lead to an activation of…

Multi-Layer Offloading at the Edge for Vehicular Networks

2020

This paper proposes a multi-layer platform for job offloading in vehicular networks. Offloading is performed from vehicles in the Vehicular Domain towards Multi-Access Edge Computing (MEC) Servers deployed at the edge of the network, and between MEC Servers. Offloading decisions at both domains are challenging for the overall system performance. Optimization at the MEC Layer domain is obtained by model-based Reinforcement Learning, while a strategy to decide the best offloading rate from the Vehicular Domain is defined to achieve the desired trade-off between costs and performance. Numerical analysis shows the achieved performance.

Temporal dynamic of biofilms enhances the settlement of the central-Mediterranean reef-builder Dendropoma cristatum (Biondi, 1859).

2021

Abstract Research on marine invertebrate settlement provides baseline knowledge for restoration technique implementation, especially for biogenic engineers with limited dispersion ability. Previously, we determined that the maturity of a biofilm strongly enhances the settlement of the vermetid reef-builder Dendropoma cristatum. To elucidate settlement-related biofilm features, here we analyse the structure and composition of marine biofilms over time, through microscopic observations, eukaryotic and prokaryotic fingerprinting analyses and 16S rDNA Illumina sequencing. The vermetid settlement temporal increase matched with the higher biofilm coverage on the substratum and the reduction of th…

Verzeichnis der Wirbeltiere der Ostseeprovinzen unter Angabe der in den Sammlungen des Naturforscher-Vereins zu Riga befindlichen Exemplare [Verzeich…

1881

Inhalt: Vorwort / G. Schweder ; [Verzeichnis]: Mammalia. Säugethiere ; Aves. Vögel ; Reptilia. Reptilien ; Amphibia. Nackte Amphibien ; Pisces. Fische.

Sicilian Cenozoic sharks from the collections of G. G. Gemmellaro Museum

2006

Common genetic variation of the cholesteryl ester transfer protein gene strongly predicts future cardiovascular death in patients with coronary arter…

2003

OBJECTIVES We sought to evaluate the association between cholesteryl ester transfer protein (CETP) genotypes and the risk of future cardiovascular mortality in patients with coronary artery disease (CAD). BACKGROUND Polymorphisms of the CETP gene influence CETP activity and high-density lipoprotein (HDL) cholesterol concentration and might affect the long-term prognosis and response to statin therapy in patients with CAD. METHODS We used serum samples and deoxyribonucleic acid collected at baseline from a prospective cohort of 1,211 patients with CAD prospectively followed up (median follow-up of 4.1 years), 82 of whom experienced a fatal cardiovascular event. The CETP/C-629A and I405V poly…

Who can go back to work when the COVID-19 pandemic remits?

2020

AbstractThis paper seeks to determine which workers affected by lockdown measures can return to work when a government decides to apply lockdown exit strategies. This system, which we call Sequential Selective Multidimensional Decision (SSMD), involves deciding sequentially, by geographical areas, sectors of activity, age groups and immunity, which workers can return to work at a given time according to the epidemiological criteria of the country as well as that of a group of reference countries, used as a benchmark, that have suffered a lower level of lockdown de-escalation strategies. We apply SSMD to Spain, based on affiliation to the Social Security system prior to the COVID-19 pandemic…

Machiavellego rozumienie dobra i zła

2015

Niccolo Machiavelli’s way of understanding the notions of good and evil rely on his theory of the origins of communities, according to which their basic structure is build around the figures of founders. Communities are kept alive by the constant effort make by their members to take care of common good and practice of crafts of peace. Forces opposed to the founders and disarraying the social life can be described as the figures on the continuum stretched between traitors, as Brutus or Judas, and lazy-bones or cowards, parasiting on the fruits of common labor. This way of understanding the good and the evil has its roots in the age of Athenian Enlightenment – in the conception of virtue ethi…