Search results for "RATES"

The effect of variation in developmental mode on the population dynamics of a spionid polychaete (Pygospio elegans) in a heterogeneous environment

2018

Detailed modeling of the kraft pulping chemistry : carbohydrate reactions

2020

The article introduces a detailed model for carbohydrate chemistry in kraft pulping. This article is continuation to the modeling work carried out for hot water extraction and chemical pulp bleaching. The model includes galactoglucomannan, xylan, and cellulose acid–base equilibria, in addition to peeling, stopping, and alkaline hydrolysis reactions of the same carbohydrates, as well as hexenuronic acid formation and degradation reactions. The Arrhenius parameters were applied from the literature or regressed against experimental data in the present study. The model is very successful in predicting the experimental data of carbohydrate reactions during kraft pulping. Many features of the pul…

Jakiego "Sokratesa" nie wystawili Lenartowiczowi aktorzy warszawscy w 1884 roku?

2022

„Poemat dramatyczny” Teofila Lenartowicza Sędziowie ateńscy (1895), wydany dopiero po śmierci autora, nie tylko powstawał przez kilka lat, lecz także był prawdopodobnie kilka razy pisany od nowa pod różnymi tytułami (m.in. Sokrates). Z niektórych jego wersji zachowały się drukowane fragmenty, inne pozostały w rękopisach. Jedną z redakcji wcześniejszych, nietożsamą z tekstem wydanym na podstawie ostatniego autografu, była wersja przygotowana dla teatru w 1884 roku. Powody rezygnacji z wystawienia nie są dokładnie znane. Egzemplarz odebrany z teatru zachował się w stanie mocno niekompletnym (obejmuje tylko jeden z pięciu aktów), ale tekst dramatu w nim zapisany pokrywa się z innym odpisem, na…

Bright spots in the darkness of cancer: A review of starfishes-derived compounds and their anti-tumor action

2019

The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an important phylum, whose members produce a huge number of compounds with diverse biological activities. In…

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

2020

The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances und…

Precision 71Ga – 71Ge mass-difference measurement

2016

The 71Ga(νe, e−) 71Ge reaction Q value has been measured with the JYFLTRAP mass spectrometer at the IGISOL facility of the University of Jyv¨askyl¨a to Q = 232.443(93) keV. This value agrees with previous measurements, though it features a much higher accuracy. The Q value is being discussed in the context of the solar neutrino capture rate in 71Ga. peerReviewed

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

2001

Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 ( a d isintegrin a nd m etalloprotease) as a major target of the cholesterol effects on APP metabolism. Treatment of various peripheral and neural cell lines with either the cholesterol-extracting agent methyl-β-cyclodextrin or the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin resulted in a drastic increase of secreted α-secretase cleaved soluble APP. This strong stimulatory effect was in the range obtained with phorbol esters and was further increa…

Data from: Patterns of ecological diversification in thelodonts

2018

Here we explore the spatial, temporal and phylogenetic patterns of ecological diversification for the entire clade of thelodonts, one of the earliest groups of vertebrates and longest lasting of the Palaeozoic agnathans in the fossil record. Parsimony and maximum-likelihood methods are used to reconstruct ancestral states of their geographical distributions, habitats and lifestyles. Our results support the concept that thelodonts originated during the Middle?–Late Ordovician probably in marine open waters of Laurasia, with a demersal lifestyle on hard substrates being the ancestral condition for the whole clade. Later, thelodonts underwent a complex ecological diversification and palaeobiog…

Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells.

2000

This paper studies the effects caused in human retinoblastoma Y79 cells by treatment with combinations of sodium butyrate, the inhibitor of topoisomerase I camptothecin and the inhibitor of 26S proteasome MG132. The combination of sodium butyrate and camptothecin resulted in a strong synergistic cytotoxicity, as revealed by combination indices of 0.77 and 0.52 calculated at IC(50) and IC(75). Synergistic interactions were also demonstrated for combinations of sodium butyrate and MG132, camptothecin and MG132 and for a combination of all three compounds. The cytotoxic effects observed after the combined treatments can be considered a consequence of apoptosis, as suggested by the appearance o…

The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule.

1990

The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c mice with MCF-7 breast tumor cells together with synthetic Gal-GalNAc linked to a BSA carrier. One monoclonal antibody (82-A6) was established which recognizes the Thomsen-Friedenreich antigen according to the biochemical and serological analysis presented here. In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhib…