Search results for "RATS"
showing 10 items of 3537 documents
Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation meta…
2003
We have synthetised a series of oxidised apomorphine derivatives (orto and para quinones 2-5), in order to analyse their vascular activity. We have performed radioligand binding assays on rat cortical membranes and functional studies on rat aortic rings. Instead the relaxant activity exhibited by (R)-apomorphine, o-quinones 2, 4, show contractile activity dependent on endothelium in rat aortic rings. Compound 2, the main metabolite of (R)-apomorphine auto-oxidation, was the product which showed enhanced contractile activity by a complex mechanism related to activation of Ca(2+) channels through release and/or inhibition of endothelial factors. Moreover, this compound disrupts the endothelia…
Vascular Activity of (-)-Anonaine, (-)-Roemerine and (-)-Pukateine, Three Natural 6a(R)-1,2-Methylenedioxyaporphines with Different Affinities for α1…
2004
We have studied the mechanism of action of three 6a( R)-1,2-methylenedioxyaporphines as vasorelaxant compounds. The alkaloids assayed showed different affinities for the three human cloned alpha (1)-adrenoceptor (AR) subtypes stably expressed in rat-1 fibroblasts, showing lower affinity for alpha(1B)-AR with regard to the alpha(1A)- or alpha(1D)-subtypes. These three natural compounds are more potent inhibitors of [ (3)H]-prazosin binding than of [ (3)H]-diltiazem binding to rat cerebral cortical membranes. As all these alkaloids inhibited noradrenaline (NA)-induced [ (3)H]-inositol phosphate formation in cerebral cortex and rat tail artery, they may be safely viewed as alpha (1)-AR antagon…
A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.
1996
1. The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) and alpha 1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition binding in rat cerebral cortex. WB 4101 and benoxathian were used as selective alpha 1A-adrenoceptor antagonists. 2. In the competition experiments [3H]-prazosin (0.2 nM) binding was inhibited by WB 4101 and benoxathian. The inhibition curves displayed shallow slopes which could be subdivided into high and low affinity components (pKi = 9.92 and 8.29 for WB 4101, 9.35 and 7.94 for benoxathian). The two antagonists recognized approximately 37% of the sites with h…
Arbitrage international. Arbitrage multiparties, Groupe de contrats, Clauses compromissoires incompatibles, Consolidation (non)
1991
International audience; (Versailles, 7 mars 1990, Rev. arb. 1991. 326, note Loquin)
Confirmation de l'application du principe de l'efficacité internationale de la clause compromissoire à la transmission de la convention d'arbitrage
2002
International audience; (Cass. 1re civ., 28 mai 2002, inédit, Sté Burkinabe des ciments et matériaux c/ Sté Des ciments d'Abidjan)
Clause compromissoire. Chaîne de contrats translatifs de propriété. Transmissibilité aux acquéreurs subséquents. Exception : preuve de l'ignorance ra…
2001
International audience; (Cass. 1re civ., 6 févr. 2001, Peavey Company c/ Organisme général des fourrages, D.2001.1135, obs. P. Delebecque)
De la transmission et de l'extension de la clause compromissoire : un « grand arrêt » de la première chambre civile de la Cour de cassation
2007
International audience; (Civ. 1re, 27 mars 2007, Sté Alcaltel Business Systems et autre c/ Sté Amkor Technology et autres, Rev. arb. 2007. 247 ; D. 2007. Jur. 2077, note S. Bollée)
Arbitrage international. Clause compromissoire - champs d'application, Chaîne non translative de contrats - Principe de l'effectivité de la clause co…
1996
International audience; (Paris, 22 mars 1995, Sté Aquaboulevard et autres c/ Sté Statinor et autres, inédit)
La responsabilité civile des arbitres en cas de dépassement du délai de l'arbitrage
2006
International audience; (Cass. 1re civ., 6 déc. 2005, pourvoi n° 03-13.116, D. 2006, Jur. p. 274, note P.-Y. Gautier ; RTD civ. 2006, p. 144, obs. P. Théry ; J. Paillusseau, L'arbitre responsable du délai d'arbitrage, JCP E, 2006, n° 1395, p. 460 ; G. Chabot, JCP 2006, 1284)
Biological effects of inorganic arsenic on primary cultures of rat astrocytes
2010
It is well established that inorganic arsenic induces neurotoxic effects and neurological defects in humans and laboratory animals. The cellular and molecular mechanisms of its actions, however, remain elusive. Herein we report the effects of arsenite (NaAsO2) on primary cultures of rat astrocytes. Cells underwent induction of heat shock protein 70 only at the highest doses of inorganic arsenic (30 and 60 microM), suggesting a high threshold to respond to stress. We also investigated arsenic genotoxicity with the comet assay. Interestingly, although cells treated with 10 microM arsenite for 24 h maintained >70% viability, with respect to untreated cells, high DNA damage was already observed…