Search results for "RAV"
showing 10 items of 5866 documents
Rapid in vitro test to predict ocular tissue permeability based on biopartitioning micellar chromatography.
2003
The drug permeability prediction across the ocular tissues is important in the development of new drugs and drug delivery strategies. Physicochemical characteristics of drugs, mainly acid-base character, hydrophobicity and the molecular size determine both their transport across the eye tissue barriers and their retention in biopartitioning micellar chromatography (BMC). An in vitro model able to describe and predict the whole cornea drug permeability is proposed. The model uses the retention of drugs in BMC and molecular weight (MW) as predictive variables. The relationships between drug retention data in BMC and their bibliographic permeability values in stroma, epithelium-plus-stroma and…
Therapeutic Monitoring of Aripiprazole by HPLC with Column-Switching and Spectrophotometric Detection
2005
Aripiprazole is a novel atypical antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders (1)(2)(3). The drug is metabolized by the cytochrome P450 isoenzymes 3A4 and 2D6 (4). Because of high interindividual variability in the expression of these enzymes, the aripiprazole concentration varies among healthy individuals after administration of the drug (5). In patients, insufficient response or side effects, such as somnolence, akathisia, or nausea, may result from too low or too high drug concentrations. Therapeutic drug monitoring (TDM), which is established practice for many antipsychotic drugs (6)(7), may be helpful for patients treated with aripiprazole. We mea…
Adriamycin and Daunomycin in the Treatment of Vesical and Prostatic Neoplasias. Preliminary Results
1972
Our preHrninary experience with adriamycin in tumors of the bladder and prostate is of 25 treatments performed in 21 patients. The discrepancy between the numbers of patients and treatments is due to the fact that some patients were again submitted to various therapeutic cycles upon subsequent admissions. The treatments administered to the same patient at different times are considered individually, with regard either to a different schedule and way of administration of the drug, or to the interposition of other therapeutic means in the intervals between treatments. In addition, 13 patients were treated with daunomycin, as shown in Table 1.
Triplet stabilization for enhanced drug photorelease from sunscreen-based photocages
2021
[EN] Recently, sunscreen-based drug photocages have been introduced to provide UV protection to photoactive drugs, thus increasing their photosafety. Here, combined experimental and theoretical studies performed on a photocage based on the commercial UVA filter avobenzone (AB) and on the photosensitizing non-steroidal anti-inflammatory drug ketoprofen (KP) are presented unveiling the photophysical processes responsible for the light-triggered release. Particular attention is paid to solvent stabilization of the drug and UV filter excited states, respectively, which leads to a switching between the triplet excited state energies of the AB and KP units. Most notably, we show that the stabiliz…
Erstellung einer Kompatibilitätstabelle für die intravenöse Pharmakotherapie auf neonatologischen und pädiatrischen Intensivstationen
2007
Background Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand and on the other hand to avoid complications from incompatibilities of the administered drugs, we compiled a compatibility chart, encompassing more substances than covered in previously available charts. Methods Information on compatibility of commonly prescribed drugs was collected by analysis of manufacturers' information, medical and pharmaceutical handbooks, and a literatu…
The control of abstinence in the treatment of alcohol dependence: the use of acamprosate in relapse prevention
2014
"The alcoholism can also deal with drug treatments." This is the message that emerges from the press conference of presentation of Campral, trade name of acamprosate, a neuromodulator specifically indicated in the maintenance of abstinence in alcohol-dependent patients.Alcoholism is a disease characterized by: craving, loss of control, tolerance and physical dependence.For many years the prevention of relapse in use of alcohol after detoxification was supported almost exclusively by psychosocial procedures and techniques with modest success. Treatment with acamprosate is a valid tool to complement psychotherapy as it does not cause addiction, abuse or withdrawal of its suspension and does n…
Management of chemotherapy extravasation: ESMO–EONS Clinical Practice Guidelines
2012
Extravasation is the process by which any liquid (fluid or drug) accidentally leaks into the surrounding tissue. In terms of cancer therapy, extravasation refers to the inadvertent infiltration of chemotherapy into the subcutaneous or subdermal tissues surrounding the intravenous or intra-arterial administration site. Extravasated drugs are classified according to their potential for causing damage as ‘vesicant’, ‘irritant’ and ‘nonvesicant’ (Table 1). Some vesicant drugs are further classified into two groups: DNA binding and non-DNA binding. Allwood et al. (2002) divided the drugs into vesicants, exfoliants, irritants, inflammitants and neutrals.
SAFETY OF REPEATED MDCT WITH CONTRAST COMPOUND IN CASE OF PREVIOUS MILD OR MODERATE ADVERSE REACTION: A SINGLE CENTRE RETROSPECTIVE STUDY.
2015
Aims and objectives Methods and materials Results Conclusion Personal information References
CONTRIBUTIONS TO (COLEOPTERA: STAPHYLINIDAE) IN DUMBRAVA SIBIULUI FOREST, ROMANIA IN TERMS OF THE YEARS 2013-2014
2015
This research study describes the results obtained during the years 2013-2014 by capturing in the soil traps, the epigenous artropodofauna in the Dumbrava Sibiului Forest. In addition, the entomofauna structure was studied and ecological interpretations were achieved regarding aspects such as: abundance, dominance, phenology of the collected species collected making a their description from an ecological and ethological point of view. Also the Species were presented and biologically described at the capture data. The experience was run in the period 2013- 2014 (April 2, 2013 and March 21, 2014) and some of the data were taken from a study conducted from 2011-2014 by author together with the…
Les partis politiques en Grande-Bretagne
2013
National audience; La vie politique en Grande-Bretagne est marquée par l’une des histoires les plus riches et anciennes d’Europe, mais son originalité reste largement méconnue – surtout par le public francophone, qui la réduit trop souvent à l’affrontement des deux grands partis dominants : Labour et Tories.D’où le présent ouvrage qui analyse l’ensemble des partis politiques, en soulignant la force des changements intervenus récemment en Grande-Bretagne. Fondé sur une définition précise du parti politique, il tient compte des multiples dimensions des organisations partisanes (idéologie-valeurs, ressources, soutiens). Il insiste aussi sur la modernisation des grands partis majoritaires (New …