Search results for "RAV"
showing 10 items of 5866 documents
Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model
2021
AbstractBackgroundDravet syndrome is a rare, severe pediatric epileptic encephalopathy associated with intellectual and motor disabilities. Proteomic profiling in a mouse model of Dravet syndrome can provide information about the molecular consequences of the genetic deficiency and about pathophysiological mechanisms developing during the disease course.MethodsA knock-in mouse model of Dravet syndrome with Scn1a haploinsufficiency was used for whole proteome, seizure and behavioral analysis. Hippocampal tissue was dissected from two-(prior to epilepsy manifestation) and four-(following epilepsy manifestation) week-old male mice and analyzed using LC-MS/MS with label-free quantification. Pro…
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis
2019
Background Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different h…
Evolutionary sequences of rotating protoneutron stars
2004
We investigate the evolution of rigidly and differentially rotating protoneutron stars (PNSs) during the first twenty seconds of their life. We solve the equations describing stationary axisymmetric configurations in general relativity coupled to a finite temperature, relativistic equation of state, to obtain a sequence of quasi-equilibrium configurations describing the evolution of newly born neutron stars. Our estimates show that the scale of variation of the angular velocity in a PNSs is of the order of 7-10 km. We obtain the maximum rotation frequency that can be reached as the protoneutron stars deleptonizes and cools down, as well as other relevant parameters such as total angular mom…
Smooth and non-smooth traveling wave solutions of some generalized Camassa–Holm equations
2014
In this paper we employ two recent analytical approaches to investigate the possible classes of traveling wave solutions of some members of a recently-derived integrable family of generalized Camassa-Holm (GCH) equations. A recent, novel application of phase-plane analysis is employed to analyze the singular traveling wave equations of three of the GCH NLPDEs, i.e. the possible non-smooth peakon, cuspon and compacton solutions. Two of the GCH equations do not support singular traveling waves. The third equation supports four-segmented, non-smooth $M$-wave solutions, while the fourth supports both solitary (peakon) and periodic (cuspon) cusp waves in different parameter regimes. Moreover, sm…
Regular and singular pulse and front solutions and possible isochronous behavior in the short-pulse equation: Phase-plane, multi-infinite series and …
2014
In this paper we employ three recent analytical approaches to investigate the possible classes of traveling wave solutions of some members of a family of so-called short-pulse equations (SPE). A recent, novel application of phase-plane analysis is first employed to show the existence of breaking kink wave solutions in certain parameter regimes. Secondly, smooth traveling waves are derived using a recent technique to derive convergent multi-infinite series solutions for the homoclinic (heteroclinic) orbits of the traveling-wave equations for the SPE equation, as well as for its generalized version with arbitrary coefficients. These correspond to pulse (kink or shock) solutions respectively o…
L'eroico, il meraviglioso e la scultura immaginifica lungo l'asse di via Toledo a Palermo (XVI-XVIII secolo)
2017
Lungo la via Toledo (oggi corso V. Emauele) e sul suo prolungamento extra moenia (stradone di Monreale, attuale corso Calatafimi) si snoda un itinerario immaginifico che si rivela nell'iconografia delle fontane, dei monumenti e degli apparati architettonico-scultorei nei quali temi eroici, cavallereschi e fantastici si intrecciano e si sovrappongono, veicolando valori ideologici , politici, civici . Sul percorso della rinnovata strada del Cassaro, il nuovo asse rappresentativo della città e luogo deputato a "teatro"di ogni manifestazione civile e religiosa, si dispiega il "meraviglioso" che si incontrava nei libri di cavalleria, e la fantasia, i miti, le leggende risvegliati dai romanzi amo…
Tīmekļa viktorīnas "Es to zinu" izstrāde
2016
Dokumentā ir iekļauta Latvijas Universitātes Datorikas fakultātes kvalifikācijas darba “Tīmekļa viktorīna “Es to zinu”” tehniskā dokumentācija, kas ietver programmatūras prasību specifikāciju, datu bāzes projektējumu un lietotāja ekrāna formu projektējumus un aprakstus, testēšanas dokumentāciju, projekta organizēšanu, programmatūras produkta kvalitātes nodrošināšanu, konfigurācijas pārvaldības informāciju un darbietilpības novērtējumu. Izstrādātās sistēmas mērķis ir nodrošināt lietotājiem reģistrēties sistēmā, autorizēties, atbildēt uz jautājumiem un piedalīties forumos. Tiek paredzētas atsevišķas sistēmas administratora funkcijas, kas ietver tēmu, jautājumu, forumu pievienošanu un reklāmu.
Revista electrónica de investigación y evaluación educativa
2015
El proceso de alfabetización académica presenta en el sistema universitario español numerosas deficiencias en nuestros días, lo que es especialmente preocupante en el caso de los futuros maestros de Educación Infantil y Educación Primaria, dada la influencia que este colectivo tendrá en la alfabetización de los alumnos en los primeros años de escolarización. Este estudio trata de determinar qué variables definen la alfabetización académica de los estudiantes universitarios y qué prácticas docentes y discentes pueden ayudar a explicarla. Un “Cuestionario sobre hábitos lectores y escritores” fue aplicado a una población de 513 estudiantes del Grado de Magisterio de Educación Infantil y Primar…
Self-dual modules over local rings of curve singularities
2006
Abstract Let C be a reduced curve singularity. C is called of finite self-dual type if there exist only finitely many isomorphism classes of indecomposable, self-dual, torsion-free modules over the local ring of C . In this paper it is shown that the singularities of finite self-dual type are those which dominate a simple plane singularity.
Heterogeneous Firms, Globalisation and the Distance Puzzle
2015
Despite the strong pace of globalisation, the distance effect on trade is persistent or even growing over time (Disdier and Head, 2008). To solve this distance puzzle, we use the recently developed gravity equation estimator from Helpman et al. (2008) (HMR henceforth). Using three different data sets, we find that the distance coefficient increases over time when ordinary least squares (OLS) is used, while the non-linear estimation of HMR leads to a decline in the distance coefficient over time. The distance puzzle, thus, arises from a growing bias of OLS estimates. The latter is explained by an increase in the importance of the bias from omitting the number of heterogeneous exporting firms…